Test Price
2,800 AED✅ Home Collection Available
VKORC1 Gene Coumarin Resistance Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This advanced pharmacogenomic test utilises Next‑Generation Sequencing (NGS) to detect mutations in the VKORC1 gene associated with resistance to coumarin anticoagulants, including warfarin. The analysis enables precise dose individualisation, significantly reducing the risk of bleeding or thromboembolic events. DNA Labs UAE delivers this test with a diagnostic sensitivity exceeding 99.9%, supported by ISO‑accredited processing, temperature‑controlled specimen logistics, and telephonic post‑result clinical guidance. Direct billing verification is available via WhatsApp +971 54 548 8731.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (Available daily from 8 AM to 11 PM)
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The VKORC1 Gene Coumarin Resistance Genetic Test employs whole‑gene Next‑Generation Sequencing to detect both common and rare genetic variants that influence a patient’s sensitivity to coumarin anticoagulants such as warfarin. This comprehensive analysis includes the entire VKORC1 gene plus its regulatory regions, enabling detection of variants beyond the commonly tested SNP −1639G>A. The test is indicated for patients requiring long‑term anticoagulation, those with a history of coumarin resistance, or individuals experiencing adverse reactions to standard warfarin dosing.
| Feature | Our VKORC1 NGS Test | Standard Genotyping |
|---|---|---|
| Technology | Next‑Generation Sequencing (NGS) | PCR‑based targeted analysis |
| Gene Coverage | Full VKORC1 gene plus regulatory regions | Common SNPs only (e.g., −1639G>A) |
| Turnaround Time | 3–4 Weeks | 5–7 Days |
| Diagnostic Sensitivity | >99.9% (detects rare variants) | ~90% (limited to known polymorphisms) |
| Price | 2,800 AED | ~1,500 AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403 advises: “The VKORC1 genotype is a critical component in personalising warfarin therapy. However, genetic information must always be integrated with clinical monitoring including INR values. This test empowers precise dosing decisions but does not replace ongoing medical supervision.”
⚠ Medication Advisory
Do not discontinue or alter any prescribed anticoagulant medication without direct consultation with your treating physician.
Safety Exclusion & Emergency Red Flags
- Exclusion Criteria: None; the genetic test does not interfere with anticoagulation therapy. No need to stop warfarin prior to sample collection.
- ER Red Flags: If you experience unexplained severe bleeding, sudden intense headache, bloody or black tarry stools, vomiting blood, or signs of stroke, seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What does the VKORC1 gene test reveal about coumarin resistance?
A: The test identifies genetic variants in the VKORC1 gene that affect how your body responds to coumarin anticoagulants like warfarin. This information helps your doctor determine the safest and most effective dose, minimising the risk of bleeding or clotting.
2. How long does it take to get the VKORC1 NGS results in the UAE?
A: The complete NGS analysis, including bioinformatic interpretation and clinical reporting, is delivered within 3 to 4 weeks. This ensures thorough variant detection and comprehensive reporting.
3. Is home blood collection available for this genetic test?
A: Yes, VIP Mobile Phlebotomy with temperature‑controlled cold‑chain transport is available daily from 8 AM to 11 PM. A certified phlebotomist will visit your home to collect the blood sample under strict ISO‑certified protocols.
4. Do I need genetic counselling before taking this test?
A: Yes, a mandatory genetic counselling session is required prior to testing. This session covers the implications of test results, family pedigree assessment, and informed consent in accordance with UAE regulations.
5. Can I continue taking warfarin while waiting for the test results?
A: Absolutely. You should continue all prescribed medications exactly as directed by your physician. The genetic test does not require any changes to your medication regimen.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with UAE federal data protection and healthcare regulations. All genetic data is processed under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains strict confidentiality and data security protocols for all genetic information.
Clinical & Logistical Metadata
| Test Name | VKORC1 Gene Coumarin Resistance Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube), extracted DNA, or FTA card blood spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – Whole gene plus regulatory regions |
| ICD-10-CM Code | Z13.89 (Encounter for screening for other specified disorders), Z79.01 (Long term current use of anticoagulants) |
| LOINC Code | 93957-5 (VKORC1 gene targeted mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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