Test Price
1,500 AED✅ Home Collection Available
5-Fluorouracil (5‑FU) Toxicity Test in UAE – DPYD Pharmacogenomic Panel
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity for actionable DPYD variants via ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Post‑test telephonic consultation by a DHA‑licensed genetics specialist to interpret results and optimise treatment.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The 5‑Fluorouracil (5‑FU) Toxicity Test is a pharmacogenomic DNA analysis of the DPYD gene. It identifies inherited variants that significantly reduce the body’s ability to metabolise 5‑FU, a common chemotherapy agent. Results empower oncologists to personalise dosing and prevent life‑threatening toxicities before the first infusion.
| Feature | Our ISO‑Certified DPYD Panel | Empiric Dosing (No Test) |
|---|---|---|
| Methodology | High‑Resolution PCR + Next‑Generation Sequencing (NGS) | Body surface area‑based calculation only |
| Turnaround Time | 5–7 working days | Not applicable – no predictive data |
| Diagnostic Sensitivity | 99.9% for actionable DPYD variants | No genetic risk assessment; high toxicity risk in deficient patients |
Physician Insight & Safety Protocols
“This pharmacogenomic analysis is a cornerstone of personalised oncology. By evaluating DPD enzyme deficiency at the genetic level, we can pre‑emptively adjust 5‑FU dosages or substitute alternative therapies, thereby minimising the risk of severe adverse events. Patients should always discuss their genomic results with their treating oncologist before any treatment modification.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory Protocols
- Pretreatment counselling: Patients should be informed that test results may indicate a need for reduced dosing or alternative chemotherapy.
- Urgent medical attention: Seek immediate care for severe diarrhoea (≥7 episodes/day), grade 3–4 mucositis, fever >38°C with neutropenia, or hand‑foot syndrome with desquamation.
- Medication guidance: Never discontinue prescribed chemotherapy without consulting your oncologist.
Exclusion Criteria
- Patients with active severe haemolysis or profound thrombocytopenia contraindicating safe venipuncture.
- Individuals with ongoing febrile neutropenia or uncontrolled sepsis.
- Sample collection is strictly via venipuncture; home phlebotomy is possible for whole blood draws.
Patient FAQ & Clinical Guidance
1. What does the 5‑Fluorouracil Toxicity Test measure?
This test detects DPYD gene variants that impair 5‑FU metabolism, predicting risk of severe toxicity. It identifies specific mutations such as DPYD*2A, *13, and c.2846A>T to guide personalised dosing.
2. How is the sample collected and how long do results take?
A simple 4 mL blood draw into a lavender‑top EDTA tube is collected by our VIP mobile phlebotomist, shipped refrigerated (never frozen), and results are available in 5–7 working days.
3. Who should consider taking this test in the UAE?
All patients scheduled for 5‑fluorouracil chemotherapy in the UAE are strong candidates for this DHA‑endorsed test to avoid severe toxicity. It is especially recommended for colorectal, breast, and head/neck cancer cases.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance
DNA Labs UAE operates under the strict framework of Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. All genomic data is encrypted, access‑controlled, and processed solely for diagnostic purposes.
Clinical & Logistical Metadata
| Attribute | Detail |
|---|---|
| Test Name | 5‑Fluorouracil (5‑FU) Toxicity Test (DPYD Pharmacogenomic Panel) |
| Price (AED) | 1,500 |
| Turnaround Time | 5–7 Working Days |
| Sample Type / Matrix | 4 mL Whole Blood (Lavender‑top EDTA) |
| Methodology Used | High‑Resolution PCR + Next‑Generation Sequencing (NGS) |
| ICD‑10‑CM Code | Z01.89, Z15.89, Z79.899 |
| LOINC Code | 92730-6 |
| DHA Facility License & Laboratory Address | DHA License 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab: DNA Labs UAE |
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