Test Price
1,100 AED✅ Home Collection Available
DPYD Gene Mutation (5-FU Toxicity Risk) Detection Test in UAE
1100 AED | DHA Guidelines
Advanced pharmacogenomic screening for dihydropyrimidine dehydrogenase (DPD) deficiency prior to fluoropyrimidine chemotherapy.
Executive Summary & Core Metrics
Clinical sensitivity of 99.9% delivered via ISO 9001:2015 accredited, LC-MS/MS and advanced PCR correlative processing. This test identifies high-risk DPYD variants to prevent severe, potentially fatal 5-FU and capecitabine toxicities before your first chemotherapy cycle.
Test Overview & Methodology
The DPYD Pharmacogenomics Panel detects critical gene mutations responsible for dihydropyrimidine dehydrogenase (DPD) enzyme deficiency. Identifying variants like *2A, *13, and rs67376798 is essential to stratify a patient's risk for severe, potentially life-threatening toxicity before administering fluoropyrimidine-based chemotherapy (5-FU, capecitabine). As a DHA-endorsed precision medicine tool, this test shifts oncology practice from reactive management to proactive, genotype-guided dosing.
| Feature | DNA Labs UAE | Closest Alternative |
|---|---|---|
| Diagnostic Precision | LC-MS/MS Corroborated PCR / Full Gene Sequencing | Standard End-Point PCR / Limited Variant Panels |
| Methodology & Compliance | ISO 9001:2015 & DHA/MOHAP Standardized Nomenclature | Legacy Molecular Methods / Minimal UAE Regulatory Audit |
| Turnaround Time | 12-15 Working Days (Clinically Actionable) | Often > 15 Days or Non-Expedited |
Physician Insight & Safety Protocols
"As a clinical geneticist, I view the DPYD test not merely as a lab value, but as a critical safeguard to personalize oncologic care and uphold the principle of 'first do no harm.' A genotype-guided dose reduction can be the difference between a manageable side effect and a life-threatening admission. However, this genomic result is a powerful piece of a larger clinical puzzle; it must always be interpreted alongside renal and hepatic function, concomitant medications, and the patient's overall performance status." — Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
⚠ CLINICAL NOTICE: Do not discontinue or adjust prescribed chemotherapy without direct consultation with your managing oncologist.
Critical Exclusion Criteria & Emergency Red Flags
- Active, uncontrolled infection or severe leukopenia at time of blood draw.
- Known hypersensitivity to EDTA anticoagulant (Lavender Top tube).
- Specimen frozen or subjected to extreme heat during transport.
- Patient or caregiver must seek immediate ER evaluation if they notice signs of severe myelosuppression (fever > 38.3°C, unusual bleeding, severe mucositis) while on fluoropyrimidines, regardless of DPYD result.
Patient FAQ & Clinical Guidance
1. What does a positive DPYD mutation test result mean for my chemotherapy treatment plan in a UAE hospital?
A positive result indicates significantly reduced DPD enzyme function, which directly informs your oncologist to initiate a mandatory, guideline-driven starting dose reduction of at least 50% for 5-FU or capecitabine to prevent severe toxicity.
2. How is the blood sample for this pharmacogenomics test collected and transported in Dubai or Abu Dhabi?
An ISO-certified phlebotomist performs a VIP mobile phlebotomy collection of 4 mL of whole blood in an EDTA lavender top tube, which is shipped under strict refrigerated cold-chain (never frozen) to prevent hemolysis, ensuring perfect sample integrity.
3. Does UAE federal law and DHA regulation mandate this test before starting fluoropyrimidine chemotherapy?
Pre-treatment DPYD genotyping is strongly recommended as a patient safety standard by the Dubai Health Authority (DHA). Leading oncology centers in the UAE integrate this test into their standard pre-chemotherapy workup to align with international guidelines. Your genomic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
4. How long does it take to get my DPYD test results, and how are they delivered?
Results are available within 12-15 working days. A confidential PDF report will be sent to you and your referring physician via secure electronic delivery. A telephonic post-test clinical guidance session is included to explain the report implications.
Clinical & Logistical Metadata
| Parameter | Value |
|---|---|
| Test Name | DPYD Gene Mutation (5-FU Toxicity Risk) Detection Test |
| Price (AED) | 1100 AED |
| Turnaround Time | 12-15 Working Days |
| Sample Type / Matrix | Whole Blood – Lavender Top (EDTA) – 4 mL |
| Methodology Used | LC-MS/MS Corroborated PCR / Full Gene Sequencing |
| ICD-10-CM Code | Z01.812 (Encounter for preprocedural laboratory examination) |
| LOINC Code | 79714-6 (DPYD gene mutation analysis) |
| DHA Facility License & Laboratory Address Invariants | DHA Facility License: 1143 Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
UAE Regulatory & Data Privacy Adherence
All data handling and clinical procedures comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety protocols align with Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License No. 1143 and operates under ISO 9001:2015 accreditation (Cert. INT/EGQ/2509DA/3139).
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians