Also known as: Thiopurine Methyltransferase Genotyping
Test Price
900 AEDโ Home Collection Available
๐ Results in 3 working days
TPMT Genotyping Test in UAE | 900 AED | DHA-Licensed Pharmacogenomics Service
DHA-Licensed Pharmacogenomics Service | ISO 9001:2015 Certified | Home Collection Available
Executive Summary & Core Metrics
Executive Summary: Our TPMT genotyping assay achieves 99.9% allelic discrimination through allele-specific real-time PCR with whole genome sequencing confirmation. Service includes temperature-controlled home phlebotomy (8 AMโ11 PM) and telephonic genetic counseling. A mandatory Genomic Clinical Information Form (Form 20) is required before testing. Results in 3 working days. Price: 900 AED. DHA-licensed and ISO 9001:2015 certified. For home collection, contact via WhatsApp at +971545488731.
Test Overview & Methodology
TPMT genotyping is a pharmacogenomic test that identifies genetic variants in the thiopurine methyltransferase (TPMT) enzyme, critical for predicting toxicity to thiopurine drugs (azathioprine, 6-mercaptopurine) used in oncology, gastroenterology, and autoimmune diseases. This assay ensures safe dosing and avoids life-threatening myelosuppression.
| Feature | Our Service | Closest Alternative |
|---|---|---|
| Precision | 99.9% Allelic Discrimination | Standard PCR (95โ97%) |
| Methodology | Allele-specific Real-Time PCR + WGS Confirmation | PCR only |
| Turnaround Time | 3 working days | 5โ7 days |
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics, I emphasize that TPMT genotyping is essential for personalized thiopurine therapy. This test identifies patients at high risk of severe toxicity, allowing dose adjustments from the start. I recommend correlation with blood counts and liver function tests.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory
โ ๏ธ Clinical Safety Notice: Do not discontinue prescribed medication without consulting your doctor.
Patient Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (within 4 weeks) โ may affect genotyping accuracy.
- Active severe infection or sepsis โ prioritize infection control before elective testing.
- Known anaphylaxis to phlebotomy supplies โ require physician-supervised alternative collection.
- ER Red Flags: Signs of severe myelosuppression (fever, petechiae, bleeding, pallor) โ seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What is TPMT genotyping and why do I need it before starting azathioprine?
TPMT genotyping identifies inherited variations in the thiopurine methyltransferase enzyme that affect how your body metabolizes azathioprine and 6-mercaptopurine, preventing severe bone marrow toxicity from standard dosing.
2. How is the blood sample collected, and is home collection safe?
A certified phlebotomist collects 4 mL of whole blood in a lavender-top EDTA tube using a cold-chain validated kit, ensuring sample stability without freezing, and transports it under monitored refrigerated conditions to our ISO-certified lab.
3. When will I receive my results, and how will they be explained?
Your TPMT genotype report is delivered within 3 working days via secure email, and a board-certified specialist provides a 15-minute telephonic interpretation to guide your treating physician in dose adjustment.
UAE Regulatory & Data Privacy Adherence
This test complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
Clinical & Logistical Metadata
| Test Name | TPMT Genotyping (Thiopurine Methyltransferase) |
| Price (AED) | 900 AED |
| Turnaround Time | 3 working days |
| Sample Type / Matrix | Whole blood (EDTA tube) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Allele-specific Real-Time PCR with Whole Genome Sequencing Confirmation |
| ICD-10-CM Code | Z13.89 |
| LOINC Code | 37011-6 |
| DHA Facility License & Laboratory Address | DHA License #1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required", "Inform lab of any recent blood transfusions (within 4 weeks)"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians