Test Price
700 AED✅ Home Collection Available
DPYD Genotyping for 5-Fluorouracil (5-FU) Toxicity & Chemotherapeutic Response in UAE | 700 AED
Executive Summary & Core Metrics
✓ 99.9% Diagnostic Sensitivity — ISO 9001:2015 Accredited Molecular Laboratory (Cert: INT/EGQ/2509DA/3139)
✓ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily from 8 AM to 11 PM across all UAE emirates
✓ Telephonic Post-Test Guidance — Board-certified clinical pharmacist interprets your DPYD genotype within 3–4 business days
✓ Insurance Direct Billing — Verify your policy via WhatsApp: +971 54 548 8731
✓ DHA Facility License No. 1143 — Full UAE regulatory compliance for pharmacogenomic testing
Test Overview & Methodology
This Sanger sequencing‑based test detects pathogenic variants in the DPYD gene (e.g., *2A, *13, rs67376798) to predict severe, potentially fatal toxicity from fluoropyrimidine chemotherapy (5‑fluorouracil, capecitabine). Clinicians across Dubai, Abu Dhabi, and Sharjah rely on this pre‑treatment screen to personalise dosing, reduce life‑threatening adverse events, and align with international oncology standards for precision medicine.
Our DPYD Genotyping vs. Other Approaches
| Parameter | Our Test (DHA‑Licensed 1143) | Common Commercial Panels |
|---|---|---|
| Methodology | Sanger Sequencing + PCR confirmation, gold‑standard for targeted variants | Often mass‑spec genotyping arrays; may miss rare UAE-relevant alleles |
| Turnaround Time | 3–4 business days | 5–10 business days |
| Clinical Report | CPIC‑level interpretation with dose‑adjustment guidance per phenotype | Often generic variant listing without actionable recommendations |
| Regulatory Compliance | Full UAE PDPL, Federal Law No. 2 of 2019, DHA/MOHAP standards | May lack local data‑privacy certifications |
| Price | 700 AED | Often 1,200–2,000 AED |
Physician Insight & Safety Protocols
"DPYD genotyping is a cornerstone of precision oncology in the UAE. A normal result does not eliminate toxicity risk entirely—clinical vigilance remains essential. I always correlate genotype findings with baseline blood counts, renal function, and concomitant disease before finalising the 5‑FU starting dose."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Medication Advisory
🚨 Important Safety Information
Do not discontinue any prescribed chemotherapy or supportive medication without explicit instruction from your treating oncologist. This test is for pre‑treatment optimisation; altering current therapy without medical oversight may cause disease progression or unacceptable toxicity.
- Emergency Red Flags after 5‑FU: If you experience sudden severe diarrhoea, fever exceeding 38.5 °C, mucositis preventing oral intake, or chest pain, proceed to the nearest emergency department immediately.
- Pre‑Test Requirements: A valid physician prescription is required for DPYD testing. Please provide the prescription during home collection or upload via WhatsApp for verification.
Exclusion Criteria & Contraindications
Contraindications
- Not intended for patients currently in active anaphylaxis, haemodynamic instability, or those unable to give informed consent for genetic testing as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Elective surgery planning, pregnancy (where fluoropyrimidines are contraindicated), or international travel documentation cases may proceed with appropriate physician approval and documented clinical rationale.
Patient FAQ & Clinical Guidance
1. Why is DPYD testing necessary before starting 5‑FU chemotherapy?
DPYD deficiency can turn standard 5‑FU into a life‑threatening event due to severe myelosuppression. Up to 5% of the population carries a high‑risk variant that drastically reduces the enzyme's activity, leading to profound neutropenia, diarrhoea, and hand‑foot syndrome. Identifying your phenotype allows the oncologist to lower the starting dose by 50% or switch to a non‑fluoropyrimidine regimen, dramatically improving safety while preserving anticancer efficacy. All testing is performed under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
2. How is the test performed and when will I receive results?
A single peripheral blood draw collected by our cold‑chain phlebotomy team yields your genotype in 3–4 business days. No fasting or special preparation is required. The sample is processed in our ISO‑certified molecular lab using Sanger sequencing to detect the four clinically actionable DPYD variants most prevalent in Middle Eastern populations. Results are released via secure patient portal with DHA‑compliant encryption. You may request a 15‑minute telephonic interpretation session with a clinical pharmacist to discuss your results in detail.
3. Will my insurance cover the 700 AED cost?
Most UAE‑based insurers reimburse DPYD genotyping when pre‑authorised as a pharmacogenomic necessity for chemotherapy planning. Coverage is expanding under updated DHA oncology guidelines. Send a photo of your insurance card via WhatsApp to +971 54 548 8731, and our billing team will confirm your eligibility and handle direct billing within 2 hours. If self‑pay, the 700 AED includes home collection, cold‑chain logistics, and the complete clinical report.
4. Is a prescription required for DPYD genotyping?
Yes, a valid physician prescription is required for DPYD testing in accordance with DHA regulatory standards. This ensures that the test is clinically indicated and that results are integrated into your oncology care plan by your treating physician. Please provide the prescription during home collection or upload via WhatsApp for verification before processing.
5. What do the results mean for my treatment plan?
Your DPYD genotype is classified into one of four phenotypes: normal metaboliser, intermediate metaboliser, poor metaboliser, or uncertain significance. Poor metabolisers require a 50% dose reduction of 5‑FU or alternative therapy. Intermediate metabolisers may need a 25–50% reduction. Your oncologist will integrate these findings with your clinical status to determine the safest and most effective treatment strategy tailored specifically to your genetic profile.
UAE Regulatory & Data Privacy Adherence
This service operates under DHA Facility License No. 1143 and adheres to the following UAE federal regulations:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — ensuring your genetic and health data remain confidential and securely processed throughout the testing lifecycle.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — governing the secure handling of electronic health records, telemedicine services, and digital reporting systems.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — establishing the framework for patient consent, clinical safety, and professional accountability in diagnostic and therapeutic services.
ISO 9001:2015 Quality Management System (Cert: INT/EGQ/2509DA/3139) guarantees traceable, validated results. All genetic counselling adheres to DHA/MOHAP scope‑of‑practice regulations for pharmacogenomic testing.
Corporate Lab Branding: DNA Labs UAE | Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | DPYD Genotyping for 5-Fluorouracil (5-FU) Toxicity & Chemotherapeutic Response |
| Price (AED) | 700 AED |
| Turnaround Time | 3–4 business days |
| Sample Type / Matrix | Peripheral whole blood — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Sanger Sequencing + PCR confirmation |
| ICD-10-CM Code | Z13.79, Z51.11, T45.1X5A |
| LOINC Code | 81224-6 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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