Test Price
2,800 AED✅ Home Collection Available
ABCB1 Gene Colchicine Resistance Genetic Test in UAE
Executive Summary & Core Metrics
Premium Logistics: ISO-Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (8 AM – 11 PM). Clinical Guidance: Telephonic Post-Test Interpretation by DHA-Licensed Specialists. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Core Metrics: 99.9% Diagnostic Sensitivity, Next-Generation Sequencing methodology, 3–4 week turnaround.
Test Overview & Methodology
The ABCB1 Gene Colchicine Resistance Genetic Test is a targeted pharmacogenomic assay that analyzes ABCB1 gene variants responsible for altered colchicine response, guiding precise therapeutic dosing and alternative therapy decisions. This test is essential for patients with gout or Familial Mediterranean Fever where colchicine efficacy is suboptimal.
| Feature | Our Test (NGS) | Closest Alternative (PCR Single-Locus) |
|---|---|---|
| Precision & Sensitivity | 99.9% Diagnostic Sensitivity, covers all known ABCB1 variants | ~85% accuracy, limited to 2–3 common polymorphisms |
| Methodology | Next-Generation Sequencing (NGS) with confirmatory Sanger validation | Real-Time PCR / RFLP |
| Turnaround Time | 3 to 4 Weeks (comprehensive report) | 1–2 Weeks (incomplete variant coverage) |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I emphasize that this ABCB1 genotype must be correlated with the patient’s full clinical picture—including colchicine tolerance, renal function, and co-medications—before any therapeutic decision. This test does not replace clinical judgment but offers a robust genetic compass for personalised dosing. Any dose adjustment must always be supervised by the prescribing physician."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Critical Medication Warning
Do not discontinue prescribed colchicine or any other medication without consulting your doctor. A genotype result indicating potential resistance does not imply an immediate need to stop therapy; abrupt changes can trigger severe flares of gout or familial Mediterranean fever.
Patient Safety – Exclusion & Red Flags
- Exclusion Criteria: Active febrile infection, known haematopoietic disorder affecting blood collection, or recent blood transfusion within 2 weeks (may introduce donor DNA artefacts).
- Emergency Red Flags: If you experience severe muscle weakness, numbness, or signs of colchicine toxicity (nausea, vomiting, diarrhoea, abdominal pain) even at usual doses, seek emergency care immediately. These symptoms may signal life-threatening toxicity before genetic results are available.
- Pre-Test Requirement: A pre-test genetic counselling session (included) to document your family history and obtain informed consent is mandatory for all UAE patients under Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does the ABCB1 gene colchicine resistance test detect, and how can it change my treatment?
This test identifies specific ABCB1 gene variants that reduce colchicine transport in your cells, enabling your specialist to adjust dosage or switch to an alternative therapy safely.
2. How is the sample collected, and is a home visit available in the UAE?
We collect a simple blood sample via our ISO-certified cold-chain VIP Mobile Phlebotomy home service, available 8 AM–11 PM across all Emirates, with results delivered digitally within 3–4 weeks.
3. Will my data remain private and compliant with UAE laws?
Absolutely—your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), stored on encrypted DHA-licensed servers, and never shared without your explicit informed consent. Additionally, health data handling complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
UAE Regulatory & Data Privacy Adherence
This laboratory test is performed by DNA Labs UAE, a DHA-licensed facility (License No. 1143). All patient data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the use of ICT in health. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 certification and undergoes regular DHA inspections.
Clinical & Logistical Metadata
| Test Name | ABCB1 Gene Colchicine Resistance Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (standard venipuncture) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with confirmatory Sanger sequencing |
| ICD-10-CM Code | Z13.89 |
| LOINC Code | 81616-3 |
| DHA Facility License & Address | DNA Labs UAE — License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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