Test Price
700 AED✅ Home Collection Available
PDGFRβ (CMML) Gene Rearrangement FISH Test in UAE | 700 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
Clinical Guidance: Telephonic Post‑Test Result Interpretation by an Oncology Specialist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The PDGFRβ (CMML) FISH test precisely detects rearrangements of the platelet‑derived growth factor receptor beta gene located on chromosome 5q32‑33. This rearrangement is a key driver of chronic myelomonocytic leukemia (CMML) and identifies patients who may respond to targeted tyrosine kinase inhibitor therapy such as imatinib. The assay is performed on bone marrow aspirate or peripheral blood using fluorescence in‑situ hybridization, offering rapid, single‑gene resolution at an accessible price point.
| Feature | Our Test (PDGFRβ FISH) | Closest Alternative (NGS Myeloid Panel) |
|---|---|---|
| Precision / Method | Fluorescence In‑Situ Hybridization (FISH), single‑gene resolution | Next‑Generation Sequencing (multi‑gene broad panel) |
| Turnaround Time | 3–4 days | 10–14 days |
| Cost | 700 AED | >3,000 AED (typical) |
| Clinical Utility | Direct CMML confirmation & imatinib sensitivity prediction | Broad mutation profiling, longer interpretation |
Physician Insight & Safety Protocols
This FISH assay provides definitive evidence for PDGFRβ gene rearrangement to support targeted therapy decisions. However, results must always be correlated with full clinical, morphological, and cytogenetic evaluation. The test is intended for patients with a confirmed or suspected diagnosis of CMML under the supervision of a qualified haematologist or oncologist.
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Safety Exclusion Criteria & Emergency Red Flags
Important Safety Notice
- Unsupervised self‑request for minors (requires guardian consent).
- Patient without a valid UAE physician prescription (exceptions: surgery clearance, pregnancy screening, or official travel abroad under Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Active severe infection (e.g., sepsis) that may compromise sample integrity or patient stability.
🚨 Seek immediate emergency care if you develop new‑onset easy bruising, spontaneous bleeding, persistent fever >38.5°C, or sudden profound fatigue.
Patient FAQ & Clinical Guidance
1. What is the purpose of the PDGFRβ (CMML) FISH test?
Answer: PDGFRβ FISH testing detects gene rearrangements in chronic myelomonocytic leukemia to guide targeted inhibitor therapy. This assay specifically identifies the 5q32‑33 PDGFRβ rearrangement, confirming the diagnosis of CMML and predicting a favourable response to imatinib and other tyrosine kinase inhibitors. It is performed on bone marrow aspirate or peripheral blood within a hospital setting and offers a rapid, cost‑effective alternative to broader sequencing.
2. How is the sample collected and what pre-requirements exist?
Answer: A doctor’s prescription is mandatory for bone marrow or peripheral blood collection by a qualified phlebotomist within a hospital facility. Home collection is not available for this test. Fasting is not required. The sample (2‑3 mL bone marrow aspirate or 5 mL peripheral blood in an EDTA tube) is processed immediately upon arrival at our ISO‑accredited laboratory.
3. What do positive or negative results indicate for CMML?
Answer: A positive PDGFRβ rearrangement confirms CMML and indicates potential sensitivity to targeted kinase inhibitor therapy. A negative result does not exclude CMML; it may indicate an alternate molecular driver and may require extended NGS testing. All results are reviewed by our specialist, who is available for telephonic interpretation following the report.
UAE Regulatory & Data Privacy Adherence
Your personal health data is handled in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical records are processed exclusively for diagnostic purposes under strict confidentiality and data security protocols.
Clinical & Logistical Metadata
| Test Name | PDGFRβ (CMML) Gene Rearrangement FISH Test |
| Price (AED) | 700 |
| Turnaround Time | 3–4 days |
| Sample Type / Matrix | Bone Marrow Aspirate or Peripheral Blood (EDTA) |
| Methodology Used | Fluorescence In‑Situ Hybridization (FISH) |
| ICD-10-CM Code | C93.1 |
| LOINC Code | 92847-3 |
| DHA Facility License & Laboratory Address | License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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