Test Price
2,800 AED✅ Home Collection Available
CDKN2B / MEN1 Genetic Screening (Multiple Endocrine Neoplasia Type 1) – Genetic Test in UAE
Executive Summary & Core Metrics
Clinical Grade Accuracy: 99.9% diagnostic sensitivity for CDKN2B and MEN1 variants through ISO 9001:2015-certified (Cert: INT/EGQ/2509DA/3139) next-generation sequencing. Strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM by DHA-licensed phlebotomists using ISO-certified transport.
Clinical Guidance: Complimentary telephonic post-test result interpretation by a consultant medical geneticist, aligning genetic findings with your family history and future risk management.
Insurance & Billing: Direct insurance verification via WhatsApp at +971 54 548 8731. Pre-approval assistance provided.
Test Overview & Methodology
The CDKN2B / MEN1 NGS panel simultaneously evaluates multiple endocrine neoplasia type 1 (MEN1) tumor suppressor genes and the CDKN2B (p15) cell-cycle regulator, providing a comprehensive hereditary cancer risk profile. This test identifies pathogenic variants in genes linked to endocrine tumors, pancreatic neuroendocrine cancers, and familial melanoma syndromes, enabling precise surveillance or prophylactic interventions.
| Feature | Our Test (CDKN2B/MEN1 NGS Panel) | Closest Alternative (Single-Gene Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene coverage, CNV detection) | Sanger sequencing (limited to known hotspots) |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Variant Coverage | All exons ±20bp intronic boundaries, large deletions/duplications | Selected exons only, no CNV |
| Clinical Utility | MEN1 syndrome, familial atypical multiple mole melanoma, pancreatic cancer risk | Limited to MEN1 or CDKN2B alone |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I emphasize that a positive CDKN2B or MEN1 variant must be correlated with detailed family history and biochemical screening. Genetic results are not a stand-alone diagnosis but a powerful tool for preventive care. Always discuss any medication changes with your treating physician.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Advisory – Do Not Self-Adjust Prescriptions
Never discontinue any prescribed medication, including hormone replacement therapy or antidepressants, prior to genetic testing without explicit approval from your treating physician. Genetic results may inform future adjustments but should never prompt abrupt cessation of current therapy.
Exclusion Criteria & Emergency Red Flags
- Active chemotherapy or radiotherapy within the last 2 weeks (may affect DNA integrity).
- Known bone marrow failure syndromes with less than 5% circulating leukocytes – insufficient DNA yield.
- If you experience sudden severe abdominal pain, heart palpitations, or uncontrolled hypertension, seek emergency medical care; do not wait for genetic results.
- Specimens must not be frozen; use only provided FTA card or EDTA whole blood at 4°C.
Patient FAQ & Clinical Guidance
1. What does a CDKN2B/MEN1 genetic test tell me, and why do I need a genetic counselling session before it?
The test identifies inherited mutations in CDKN2B and MEN1 genes that significantly elevate lifetime risk for endocrine tumours and melanoma; pre-test counselling constructs a family pedigree to interpret results accurately and tailor screening.
2. How accurate is the NGS method for CDKN2B/MEN1, and do you report variants of uncertain significance?
With 99.9% analytical sensitivity, the NGS platform detects single nucleotide variants, small indels, and copy number changes; all variants are classified per ACMG guidelines, and VUS are reported with follow-up recommendations.
3. Can I use FTA card blood sample, and how does home collection work in the UAE?
Yes, a single drop of blood on an FTA card is stable at ambient temperature; our DHA-licensed phlebotomist arrives at your doorstep within booking hours and ensures cold-chain transport for extracted DNA or whole blood options.
4. What are the pre-test requirements for this genetic screening?
Compulsory genetic counselling session to document a comprehensive family pedigree for CDKN2B/MEN1-related conditions. Provide full clinical history, including any prior endocrine tumor diagnoses, melanoma, or pancreatic cancer in family members. No fasting required. FTA card samples must be kept dry and away from direct heat.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights. DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring that your genetic information is encrypted, access-controlled, and never shared without explicit written consent. All clinical procedures adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, guaranteeing secure electronic health records and telemedicine frameworks. Patient safety and informed consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability, safeguarding your rights throughout the testing journey.
DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | CDKN2B / MEN1 Genetic Screening (Multiple Endocrine Neoplasia Type 1) – NGS Panel |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA) or FTA card dried blood spot |
| Methodology Used | Next-Generation Sequencing (NGS) – full gene coverage with CNV detection |
| ICD-10-CM Code | E31.2 |
| LOINC Code | 94046-2 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians