Test Price
2,800 AED✅ Home Collection Available
TMC1 Gene Deafness Autosomal Recessive Type 7 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – ISO‑accredited Next‑Generation Sequencing (NGS) with full gene coverage and copy number variant detection.
- VIP Mobile Phlebotomy – Temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM by DHA‑licensed phlebotomists.
- Complimentary Post‑Test Genetic Counselling – Telephonic session with a board‑certified genetic counsellor to interpret results and guide clinical decisions.
- Direct Billing Verification – Insurance pre‑approval via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TMC1 (Transmembrane Channel‑Like 1) gene test employs Next‑Generation Sequencing (NGS) to detect pathogenic variants responsible for autosomal recessive non‑syndromic hearing loss type 7 (DFNB7). This analysis identifies causative mutations associated with prelingual, severe‑to‑profound bilateral sensorineural deafness, enabling early intervention, cochlear implantation planning, and informed family counselling. The assay includes full exon sequencing, intronic boundary coverage, and copy number variation (CNV) analysis via MLPA, delivering 99.9% analytical sensitivity and specificity.
| Feature | Our TMC1 NGS Test | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity | ~95% sensitivity; may miss deep intronic or structural variants |
| Methodology | Next‑Generation Sequencing with full gene coverage, intronic boundaries, and CNV/MLPA analysis | Sanger sequencing of coding exons only |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Clinical Depth | Includes MLPA/CNV detection for large deletions and duplications | Limited to point mutations and small insertions/deletions |
| Genetic Counselling | Complimentary pre‑ and post‑test counselling by DHA‑licensed genetic professionals | Often requires external referral |
Physician Insight & Safety Protocols
“Early genetic confirmation of TMC1‑related deafness transforms clinical management — it enables timely cochlear implantation, targeted educational interventions, and precise recurrence risk counselling for families. A negative NGS result does not exclude all hereditary or environmental causes; comprehensive audiological correlation with ABR, OAE, and family pedigree remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory – Medication Safety
Do not discontinue any prescribed medication or alter treatment plans based solely on genetic test results. Always consult your treating physician before making clinical decisions.
Exclusion Criteria & Emergency Red Flags
This test is not a screening tool for auditory neuropathy, acquired hearing loss, or syndromic forms of deafness. Seek immediate medical attention if you experience sudden hearing loss, acute vertigo, ear trauma, or facial weakness. Results must be interpreted alongside a complete audiological evaluation (ABR, OAE) and detailed family history.
Patient FAQ & Clinical Guidance
1. What does the TMC1 Genetic Test detect and who should consider it?
The TMC1 NGS test identifies disease‑causing variants responsible for autosomal recessive non‑syndromic hearing loss type 7 (DFNB7), typically presenting as severe‑to‑profound bilateral prelingual sensorineural deafness. It is recommended for individuals with congenital or early‑onset bilateral hearing loss, particularly when family history suggests recessive inheritance, and for couples seeking preconception carrier screening.
2. How is the sample collected and what are the preparation requirements?
A single peripheral whole blood sample is collected by our DHA‑licensed phlebotomists during a VIP mobile home visit or at our Dubai Healthcare City facility. The specimen is transported under temperature‑controlled cold‑chain conditions. No fasting or medication changes are required. A pre‑test genetic counselling session is strongly advised to confirm test selection and document family pedigree.
3. What happens after I receive my results and how are they protected under UAE law?
Your NGS report is delivered securely via encrypted digital channels. A licensed genetic counsellor provides a complimentary telephonic session to interpret findings, discuss recurrence risks, and guide next clinical steps. All health data is processed and stored in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Results remain strictly confidential.
UAE Regulatory & Data Privacy Adherence
All genetic testing services at DNA Labs UAE comply with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring full patient data privacy and consent governance.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing secure handling of electronic health records.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – safeguarding patient safety and clinical accountability.
- Dubai Healthcare City (DHCC) regulatory standards and DHA licensing requirements for genetic diagnostics.
Your genetic data is encrypted, access‑controlled, and never shared with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | TMC1 Gene Deafness Autosomal Recessive Type 7 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Full Gene Coverage, Intronic Boundaries, and CNV/MLPA Analysis |
| ICD-10-CM Code | H90.3 (Bilateral sensorineural hearing loss) |
| LOINC Code | 101371-1 (TMC1 gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians