Test Price
2,800 AED✅ Home Collection Available
OTOA Gene Deafness, Autosomal Recessive Type 22 Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counseling by a Board-Certified Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This advanced molecular test uses Next-Generation Sequencing (NGS) to detect pathogenic variants in the OTOA gene responsible for autosomal recessive deafness type 22. Results are delivered within 3–4 weeks, accompanied by a structured genetic counseling session to guide clinical management and reproductive planning.
Test Overview & Methodology
The OTOA NGS test analyzes the OTOA gene for disease-causing mutations that lead to autosomal recessive nonsyndromic sensorineural hearing loss type 22. Performed on Illumina platforms with >100× coverage, this assay achieves 99.9% sensitivity and specificity, providing a definitive genetic diagnosis for individuals with hereditary hearing impairment. Results are correlated with audiometric data and family history to inform early intervention, hearing habilitation, and reproductive choices.
| Feature | Our Test: OTOA NGS | Closest Alternative |
|---|---|---|
| Precision | 99.9% Sensitivity & Specificity (NGS) | ~95% (Conventional Sanger) |
| Method | Next‑Generation Sequencing (Illumina, >100× coverage) | Sanger Sequencing of OTOA exons only |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), states: “Genetic testing for OTOA-related deafness bridges the gap between clinical suspicion and personalized management. Every result must be correlated with audiometric data and a thorough family history. A positive finding empowers early hearing intervention and informed reproductive choices. Confirmatory segregation analysis in parents is recommended before clinical action is taken.”
Clinical Advisory & Genetic Counseling
This test is a diagnostic aid and does not replace comprehensive clinical evaluation by an otolaryngologist or audiologist. A positive result for two pathogenic OTOA variants confirms the genetic basis of deafness and supports eligibility for early hearing intervention programs. A negative result does not rule out other genetic or environmental causes of hearing loss. All patients are offered a telephonic post-test genetic counseling session to discuss inheritance patterns, recurrence risks, and family screening options. Do not discontinue any prescribed medication without consulting your treating physician.
Exclusion Criteria & Emergency Red Flags
- Home collection exclusion: Unaccompanied minors require guardian consent; patients with acute febrile illness, active ear infection, or known bleeding diathesis should defer sampling until resolved.
- Do not delay emergency care: Sudden severe hearing loss with vertigo, acute tinnitus, otalgia, or neurological deficits warrants immediate ER evaluation. This genetic test is not a first-line emergency diagnostic tool.
- Sample collection for this test is by peripheral whole blood or buccal swab only. If an archival tissue block or biopsy is required, separate retrieval logistics apply.
Patient FAQ & Clinical Guidance
1. What is the OTOA gene test and why is it needed?
The OTOA NGS test identifies disease-causing mutations in the OTOA gene linked to autosomal recessive deafness type 22, a form of nonsyndromic sensorineural hearing loss. It is indicated for individuals with congenital or prelingual bilateral hearing loss of unknown cause, especially those with a family history suggesting recessive inheritance. The result enables precise genetic counseling and early hearing management strategies.
2. How is the sample collected for this genetic test?
A small peripheral whole blood sample (2–3 mL in EDTA) or a buccal swab is collected via VIP Mobile Phlebotomy by a licensed nurse in the comfort of your home. The sample is transported under ISO-certified temperature-controlled cold-chain conditions to preserve DNA integrity. Home collection is available daily from 8 AM to 11 PM.
3. What do the results mean and how will I receive them?
Results indicate whether you carry two pathogenic variants in the OTOA gene, confirming the genetic diagnosis. A detailed laboratory report is issued within 3–4 weeks. You will be contacted for a telephonic genetic counseling session with a consultant medical geneticist who will explain the clinical implications, recurrence risks, and recommendations for family members. A negative result does not exclude other genetic causes; further testing may be discussed.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Health Data Protection
All genetic and personal data are processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety, laboratory standards, and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License number 1143 and operates under the regulatory oversight of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | OTOA Gene Deafness, Autosomal Recessive Type 22 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina, >100× coverage |
| ICD-10-CM Code | H90.3 (Bilateral sensorineural hearing loss) |
| LOINC Code | 21636-6 (DNA mutations detected in Blood or Tissue) |
| DHA Facility License & Lab Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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