Test Price
2,800 AED✅ Home Collection Available
DCDC2 Gene (Autosomal Recessive Deafness Type 66) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
DHA-Licensed Molecular Diagnostics – 99.9% Sensitivity
- Diagnostic Accuracy: 99.9% sensitivity via NGS on Illumina NovaSeq X Plus with confirmatory Sanger sequencing, operated under ISO 9001:2015 certification (INT/EGQ/2509DA/3139).
- Premium Logistics: VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across Dubai and the UAE.
- Clinical Guidance: Post-test telephonic interpretation by a DHA-licensed Consultant Medical Geneticist – included in the test fee.
- Insurance Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region and flanking intronic boundaries (±20 bp) of the DCDC2 gene to identify pathogenic variants responsible for autosomal recessive non‑syndromic hearing loss (DFNB66). The methodology uses the Illumina NovaSeq X Plus platform with orthogonal Sanger confirmation, enabling detection of single nucleotide variants, small insertions/deletions, and copy number variations (CNVs). The test provides a definitive molecular diagnosis for individuals with sensorineural hearing loss and their at‑risk family members, supporting informed reproductive and clinical decisions.
| Feature | Our DHA‑Standard Test | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing (exons ±20 bp) + CNV detection | Targeted panel or single‑exon Sanger only |
| Method | NGS (Illumina NovaSeq X Plus) with confirmatory Sanger | PCR + Sanger only (lower sensitivity for large deletions) |
| Turnaround Time | 3–4 weeks incl. genetic counselling report | 6–8 weeks, often without clinical interpretation |
Physician Insight & Safety Protocols
“A positive DCDC2 result must be interpreted alongside comprehensive audiometric data and a three‑generation family pedigree. This test identifies hereditary susceptibility for non‑syndromic hearing loss, not acquired forms. I strongly advise a pre‑test genetic counselling session to address recurrence risks and implications for at‑risk relatives.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre‑Test Advisory
- A detailed clinical history and audiogram must be submitted prior to sample collection.
- A mandatory genetic counselling session (in‑person or tele‑consult) is included to draw a pedigree and explain autosomal recessive inheritance.
- Inform the phlebotomist if you are taking high‑dose biotin (>5 mg/day) – an 8‑hour washout is advised to avoid interference with DNA extraction.
- Do not discontinue prescribed medications, hearing aids, or cochlear implant programming without consulting your clinician.
Exclusion Criteria & Emergency Red Flags
- Acute febrile illness or active ear infection – reschedule until full recovery.
- Recent blood transfusion (wait ≥4 weeks).
- Individuals under 18 years require parental/guardian consent in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Seek immediate emergency care if you experience sudden sensorineural hearing loss, vertigo, or facial weakness – these symptoms require urgent ENT evaluation and are not related to genetic testing.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of the DCDC2 genetic test for hereditary deafness?
The test achieves 99.9% sensitivity when performed via next‑generation sequencing with Sanger confirmation, making it the gold standard for identifying pathogenic mutations responsible for autosomal recessive non‑syndromic hearing loss (DFNB66).
2. How long does it take to receive my DCDC2 genetic test results?
Your comprehensive genetic report, including clinical interpretation and counselling notes, is delivered within 3 to 4 weeks from sample accession – faster than most overseas laboratories while remaining fully DHA‑audited.
3. What sample types are accepted, and do I need to fast?
We accept whole blood (3 mL in EDTA tube), extracted DNA, or one drop of blood on an FTA card. No fasting or special preparation is required, and paediatric pain‑free collection is available for infants. Home phlebotomy is offered daily from 8 AM to 11 PM.
4. Is genetic counselling included in the test price?
Yes, a mandatory pre‑test counselling session and a post‑test telephonic interpretation by a DHA‑licensed Consultant Medical Geneticist are included at no additional charge.
UAE Regulatory & Data Privacy Adherence
This laboratory service is provided in full compliance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring strict confidentiality of genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing safe handling of electronic health records.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – regarding patient consent and clinical safety.
ISO 9001:2015 certification: INT/EGQ/2509DA/3139. Corporate lab: DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | DCDC2 Gene Sequencing (Autosomal Recessive Deafness Type 66) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card – VIP mobile phlebotomy & cold-chain home collection available |
| Methodology Used | NGS (Illumina NovaSeq X Plus) + confirmatory Sanger sequencing, CNV detection |
| ICD-10-CM Code | H90.5 (Sensorineural hearing loss, unspecified) |
| LOINC Code | 55233-1 (Gene mutation analysis, sequence analysis) |
| DHA Facility License & Address | License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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