Test Price
2,800 AED✅ Home Collection Available
CDH23 Gene Deafness, Autosomal Recessive Type 12 (DFNB12) Genetic Test
in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CDH23 للصمم الوراثي المتنحي النوع 12 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
الملخص التنفيذي: اختبار تسلسل الجيل التالي (NGS) لجين CDH23 يُشخّص بدقة الصمم الوراثي المتنحي من النوع 12 (DFNB12) في دولة الإمارات. حساسية تشخيصية تبلغ 99.9%، خدمة سحب منزلي فاخرة وفق معايير ISO، واستشارة طبية فورية بعد النتيجة.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed genetic counsellors.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview: CDH23 Gene Diagnostic & Carrier Test
This advanced NGS test fully sequences the CDH23 gene to identify pathogenic variants responsible for autosomal recessive non-syndromic hearing loss DFNB12. It is the definitive molecular tool for confirming a clinical diagnosis, guiding early cochlear implantation, and informing family planning. يُعد هذا الفحص المعيار الذهبي لتأكيد تشخيص الصمم الوراثي المتنحي من النوع 12.
| Feature | Our Test (NGS Full Gene Sequencing) | Closest Alternative (Targeted Sanger Sequencing) |
|---|---|---|
| Precision | Covers all coding exons, splice sites & deep intronic variants – >95% analytical sensitivity | Targeted hotspot mutations only; misses rare/novel variants |
| Methodology | Next-Generation Sequencing (Illumina NovaSeq) with Sanger confirmation | Sanger sequencing of limited fragments |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Clinical Utility | Diagnosis, carrier screening, premarital counselling | Limited to previously described mutations in specific populations |
| UAE Compliance | Fully compliant with Federal Decree-Law No. 41 of 2024 & DHA genetic testing regulations | May require additional sequencing to meet DHA standards |
Physician Insight & Safety Protocol
“Genetic test results demand careful clinical correlation. A pathogenic CDH23 variant confirms DFNB12 but does not dictate immediate medical therapy; normal results do not exclude other genetic or acquired etiologies. Always integrate pure-tone audiometry and family history. – Dr. Prabhakar Reddy, DHA License: 61713011”
⚕️ Clinical Notice: Do not discontinue prescribed medication (e.g., corticosteroids, antivirals) without consulting your doctor. This test is not a substitute for acute medical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Patients with febrile illness (temperature >38°C), recent blood transfusion (within 3 weeks), or high-dose immunosuppressive therapy may yield compromised DNA quality. Re-schedule collection after recovery.
- ER Red Flags: Sudden onset (≤72 hours) sensorineural hearing loss, acute mastoiditis symptoms (pain, swelling, fever), or severe vertigo with neurological signs – seek immediate ENT emergency care, do not wait for genetic test results.
- Pediatric/Minor Consent: In line with the 2026 CDS Law, all minors require documented parental/guardian consent. Contact our team for the mandatory consent form.
Frequently Asked Questions
1. What exactly does the CDH23 NGS test detect?
It detects pathogenic variants across the entire CDH23 gene using Next-Generation Sequencing, confirming autosomal recessive deafness type 12 with >95% variant coverage.
يكتشف هذا الاختبار الطفرات الجينية في كامل جين CDH23 باستخدام تقنية تسلسل الجيل التالي، مما يؤكد تشخيص الصمم الوراثي المتنحي من النوع 12.
2. How should I prepare for the blood collection?
No fasting is required; simply hydrate well and provide a whole blood sample in EDTA tube or an FTA card spot during our home visit.
لا يشترط الصيام، كل ما عليك هو شرب الماء وتقديم عينة دم وريدي في أنبوب EDTA أو بقعة على بطاقة FTA أثناء الزيارة المنزلية.
3. What if my confirms a CDH23 mutation?
A positive result guides early intervention like cochlear implantation and family genetic counselling, with immediate telephonic support from our DHA-licensed specialists.
توجّه النتيجة الإيجابية نحو التدخل المبكر مثل زراعة القوقعة والاستشارة الوراثية للعائلة، مع دعم فوري عبر الهاتف من أخصائيين مرخصين من هيئة الصحة بدبي.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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