Test Price
2,800 AED✅ Home Collection Available
XK Gene Genetic Test for McLeod Syndrome & CGD in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين XK لمتلازمة ماكليود ومرض الورم الحبيبي المزمن في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing
Premium Logistics: Paid Hospital-Grade Home Collection (8 AM – 11 PM) with Certified Cold-Chain Transport
Clinical Guidance: Telephonic Post-Test Genetic Counseling by DHA-Licensed Clinical Team
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
ملخص تنفيذي: فحص جيني متقدم بتسلسل الجيل التالي (NGS) لجين XK، يكشف عن طفرات مسببة لمتلازمة ماكليود ومرض الورم الحبيبي المزمن، بدقة تشخيصية تصل إلى 99.9٪ وفق معايير هيئة الصحة بدبي لعام 2026. نضمن جمع عينات منزلية معتمدة بنظام سلسلة التبريد ISO 9001:2015، واستشارة وراثية هاتفية بعد النتائج. للاستفسار وفحص التأمين: واتساب +971 54 548 8731.
Comprehensive Overview of the XK Gene Test
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the XK gene to detect pathogenic variants responsible for McLeod syndrome, with or without contiguous deletion involving the adjacent CYBB gene causing X-linked chronic granulomatous disease (CGD). Delivered through ISO-certified, DHA-regulated workflows, it provides definitive molecular diagnosis, carrier status, and actionable results for pediatric and adult patients across the UAE.
| Feature | Our NGS Test (XK Gene) | Legacy Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for single nucleotide variants & copy number changes | ~95% for point mutations; misses large deletions/duplications |
| Methodology | NGS with bioinformatic analysis per ACMG 2026 guidelines; confirmed by orthogonal methods if needed | Bidirectional Sanger, limited to targeted exons |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks (fragmented workflow) |
| Simultaneous CGD Coverage | Detects contiguous gene deletions (XK-CYBB) – complete McLeod/CGD risk assessment | Cannot assess CGD; requires separate test |
| Genetic Counseling | Included: Pre-test pedigree drawing, post-test teleconsultation | Usually extra, limited availability |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011) emphasizes: “Genetic test results for the XK gene require careful clinical correlation; a positive finding may indicate McLeod syndrome with neuroacanthocytosis and risk for CGD, while a negative result does not eliminate the possibility of other neurogenetic disorders. I strongly urge families to continue all prescribed medications and maintain multidisciplinary care. Should any new neurological or hematological symptoms arise—such as movement disorders or recurrent infections—please seek immediate evaluation.”
Safety & Exclusion Criteria – Important
- Exclusion: This test cannot be performed on samples showing hemolysis, insufficient DNA yield, or improperly stored FTA cards. DNA must be extracted within 72 hours for blood samples kept at 4°C.
- Emergency Red Flags: If your child or family member experiences sudden onset of severe muscle weakness, seizures, or signs of overwhelming infection (high fever, abscesses), proceed directly to the nearest emergency department—do not wait for genetic results.
- Medication Warning: Do not discontinue any prescribed medication, especially prophylactic antibiotics or neurological treatments, without consulting your doctor. Genetic results guide therapy but do not replace clinical judgement.
- Pediatric Consent: In compliance with UAE CDS Law 2026, testing for minors requires a guardian’s informed consent following genetic counseling.
Pre-Test Requirements
Prior to sample collection, a clinical history of the patient must be provided, and a mandatory genetic counseling session is conducted to construct a comprehensive pedigree chart of family members affected by McLeod syndrome or CGD. No fasting is required. Acceptable sample types: whole blood (EDTA tube), extracted DNA, or one drop of blood on an FTA card, all handled according to ISO 9001:2015 cold-chain protocols (Cert: INT/EGQ/2509DA/3139).
Patient FAQ & Clinical Guidance
1. What does the XK gene NGS test detect, and how accurate is it for UAE patients?
This test identifies pathogenic variants in the XK gene with >99.9% diagnostic sensitivity, covering point mutations and copy number changes that cause McLeod syndrome and can indicate contiguous deletion of CYBB, thus ruling in/out CGD risk. It follows DHA 2026 protocols and is validated with UAE reference genomes for maximum accuracy.
يكشف هذا الفحص عن الطفرات المرضية في جين XK بدقة تتجاوز 99.9%، ويغطي الطفرات النقطية وتغيرات عدد النسخ المسببة لمتلازمة ماكليود، كما يشير إلى خطر الإصابة بمرض الورم الحبيبي المزمن في حال الحذف المتجاور.
2. How is the sample collected, and can I arrange home service in Dubai or Abu Dhabi?
A certified phlebotomist performs the home blood draw within our 8 AM–11 PM VIP Mobile service window, transporting the sample in an ISO-certified cold chain; FTA cards or previously extracted DNA are also accepted. We cover all Emirates, including Dubai, Abu Dhabi, Sharjah, and the Northern Emirates.
يتم جمع العينة عبر فني متمرس في المنزل خلال خدمة جمع العينات المنزلية الممتدة من 8 صباحاً حتى 11 مساءً، وفق سلسلة تبريد معتمدة ISO؛ كما نقبل بطاقات FTA والحمض النووي المستخلص.
3. Will my insurance cover this genetic test, and how quickly do I get results?
Direct billing is verified via WhatsApp before collection; many UAE insurance plans cover medically necessary genetic testing for suspected McLeod syndrome/CGD under DHA guidelines. Results are delivered in 3–4 weeks with an included post- genetic counseling session.
يتم التحقق من التغطية التأمينية عبر واتساب قبل سحب العينة، وتصدر النتائج خلال 3 إلى 4 أسابيع مصحوبة بجلسة استشارة وراثية هاتفية وفق توجيهات هيئة الصحة بدبي.
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians