Test Price
2,800 AED✅ Home Collection Available
XK Gene Genetic Test for McLeod Syndrome & Chronic Granulomatous Disease in UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM)
Clinical Guidance: Telephonic Post-Test Genetic Counseling by DHA-Licensed Clinical Team
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the XK gene to detect pathogenic variants responsible for McLeod syndrome, with or without contiguous deletion involving the adjacent CYBB gene causing X-linked chronic granulomatous disease (CGD). Delivered through ISO-certified, DHA-regulated workflows, it provides definitive molecular diagnosis, carrier status, and actionable results for pediatric and adult patients across the UAE.
Pre-Test Requirements
Prior to sample collection, a clinical history of the patient must be provided, and a mandatory genetic counseling session is conducted to construct a comprehensive pedigree chart of family members affected by McLeod syndrome or CGD. No fasting is required. Acceptable sample types: whole blood (EDTA tube), extracted DNA, or one drop of blood on an FTA card, all handled according to ISO 9001:2015 cold-chain protocols (Cert: INT/EGQ/2509DA/3139).
| Feature | Our NGS Test (XK Gene) | Legacy Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for single nucleotide variants & copy number changes | ~95% for point mutations; misses large deletions/duplications |
| Methodology | NGS with bioinformatic analysis per ACMG guidelines; confirmed by orthogonal methods if needed | Bidirectional Sanger, limited to targeted exons |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks (fragmented workflow) |
| Simultaneous CGD Coverage | Detects contiguous gene deletions (XK-CYBB) – complete McLeod/CGD risk assessment | Cannot assess CGD; requires separate test |
| Genetic Counseling | Included: Pre-test pedigree drawing, post-test teleconsultation | Usually extra, limited availability |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA License: 9294403), Consultant Medical Genetics, emphasizes: “Genetic test results for the XK gene require careful clinical correlation; a positive finding may indicate McLeod syndrome with neuroacanthocytosis and risk for CGD, while a negative result does not eliminate the possibility of other neurogenetic disorders. I strongly urge families to continue all prescribed medications and maintain multidisciplinary care. Should any new neurological or hematological symptoms arise—such as movement disorders or recurrent infections—please seek immediate evaluation.”
Advisory & Safety Precautions
Medication Warning & Emergency Red Flags
- Emergency Red Flags: If your child or family member experiences sudden onset of severe muscle weakness, seizures, or signs of overwhelming infection (high fever, abscesses), proceed directly to the nearest emergency department—do not wait for genetic results.
- Medication Warning: Do not discontinue any prescribed medication, especially prophylactic antibiotics or neurological treatments, without consulting your doctor. Genetic results guide therapy but do not replace clinical judgement.
Exclusion Criteria
Sample Rejection Criteria
- This test cannot be performed on samples showing hemolysis, insufficient DNA yield, or improperly stored FTA cards. DNA must be extracted within 72 hours for blood samples kept at 4°C.
- Pediatric Consent: In compliance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability, testing for minors requires a guardian’s informed consent following genetic counseling.
Patient FAQ & Clinical Guidance
1. What does the XK gene NGS test detect, and how accurate is it for UAE patients?
This test identifies pathogenic variants in the XK gene with >99.9% diagnostic sensitivity, covering point mutations and copy number changes that cause McLeod syndrome and can indicate contiguous deletion of CYBB, thus ruling in/out CGD risk. It follows DHA protocols and is validated with UAE reference genomes for maximum accuracy.
2. How is the sample collected, and can I arrange home service in Dubai or Abu Dhabi?
A certified phlebotomist performs the home blood draw within our VIP Mobile Phlebotomy service window (8 AM–11 PM), transporting the sample in an ISO-certified cold chain; FTA cards or previously extracted DNA are also accepted. We cover all Emirates, including Dubai, Abu Dhabi, Sharjah, and the Northern Emirates.
3. Will my insurance cover this genetic test, and how quickly do I get results?
Direct billing is verified via WhatsApp before collection; many UAE insurance plans cover medically necessary genetic testing for suspected McLeod syndrome/CGD under DHA guidelines. Results are delivered in 3–4 weeks with an included post-test genetic counseling session.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance
All genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and confidentiality are maintained throughout the testing lifecycle. The laboratory adheres to DHA regulatory standards and ISO 9001:2015 quality management.
Clinical & Logistical Metadata
| Test Name | XK Gene Genetic Test (McLeod Syndrome & CGD) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), FTA Card, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G23.0 (McLeod syndrome), D70.4 (Chronic granulomatous disease) |
| LOINC Code | 74500-4 (XK gene sequencing) |
| DHA Facility License & Lab Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians