Test Price
2,800 AED✅ Home Collection Available
MSX1 Gene (Witkop Syndrome) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Comprehensive NGS-Based Genetic Analysis
- Clinical Sensitivity: >99.9% analytical sensitivity for SNVs and small indels in the MSX1 gene.
- sample Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily, 8 AM – 11 PM).
- Clinical Context: Confirms diagnosis of Witkop syndrome (ectodermal dysplasia) and aids in reproductive risk assessment.
- Billing Support: Direct insurance pre-authorization assistance via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MSX1 Gene Genetic Test utilizes Next-Generation Sequencing (NGS) to analyze the complete coding region and intron-exon boundaries of the MSX1 gene. Pathogenic variants in MSX1 are associated with Witkop syndrome, a rare autosomal dominant disorder characterized by hypodontia and nail dysplasia.
| Feature | Our Test (NGS) | Traditional Sanger Sequencing |
|---|---|---|
| Methodology | Next‑Generation Sequencing (Full Gene Coverage) | Sanger Sequencing (Targeted Regions Only) |
| Variant Detection | SNVs, indels, CNVs, deep intronic | SNVs & small indels in exons |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Price (AED) | 2,800 | 3,200+ |
| Accreditation | ISO 9001:2015 & DHA Licensed | Variable |
Physician Insight & Safety Protocols
“The MSX1 gene is highly conserved and plays a critical role in craniofacial development. While pathogenic variants in MSX1 are a known cause of Witkop syndrome, variable expressivity means that not all carriers will exhibit the full classic triad of missing teeth, sparse hair, and nail dystrophy. A comprehensive clinical evaluation by a consultant medical geneticist is strongly advised to correlate genotype with phenotype.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Patient Advisory & Informed Consent
Mandatory Pre-Test Genetic Counseling
In accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability, informed consent must be obtained by a qualified genetic counselor prior to sample collection. This session ensures that the patient understands the scope of the test, potential findings (including variants of uncertain significance), and the implications for family members.
Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Active febrile illness, inability to provide informed consent, or minors without legal guardian consent.
- ER Red Flags: Seek immediate medical attention if you experience severe anxiety, depression, or suicidal ideation upon receiving genetic results; contact emergency services or your clinical geneticist immediately.
Patient FAQ & Clinical Guidance
1. What is the MSX1 Gene Witkop Syndrome Genetic Test?
This is a targeted NGS test that sequences the entire MSX1 gene to identify pathogenic variants responsible for Witkop syndrome (OMIM #189500). It is used to confirm clinical diagnoses, differentiate from other ectodermal dysplasias, and provide accurate recurrence risk counseling.
2. How should I prepare for this genetic test?
No special preparation such as fasting is required. A mandatory pre-test genetic counseling session will be arranged to review the test's implications. Sample collection can be performed via a routine blood draw (EDTA tube) or FTA card, either at our Dubai Healthcare City facility or through our mobile phlebotomy service (8 AM – 11 PM).
3. When will I get my results and how are they interpreted?
Results are typically delivered within 3 to 4 weeks. The report includes a detailed interpretation of any identified variants, their clinical significance (pathogenic, likely pathogenic, or VUS), and a management recommendation. A post-test teleconsultation with the referring physician or our clinical geneticist is provided to explain the findings.
UAE Regulatory & Data Privacy Adherence
Your Data is Protected Under UAE Law
DNA Labs UAE operates strictly in compliance with the UAE’s robust legal framework for health data and personal privacy:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Governs the processing, storage, and transfer of your personal genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of ICT in Health Fields: Regulates the electronic handling of medical records and diagnostic data to ensure confidentiality and integrity.
- All genetic data is anonymized for research purposes only after obtaining explicit, informed consent. You have the right to access, rectify, and request deletion of your data.
Clinical & Logistical Metadata
| Test Name | MSX1 Gene (Witkop Syndrome) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS), Full Gene Coverage |
| ICD-10-CM Code | Q82.4 (Ectodermal dysplasia) |
| LOINC Code | 91748-0 (MSX1 gene targeted mutation analysis) |
| DHA Facility License & Address | DHA License 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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