Test Price
2,800 AED✅ Home Collection Available
TTBK2 Gene Spinocerebellar Ataxia Type 11, Autosomal Dominant Genetic Test in UAE
Executive Summary & Core Metrics
Executive Summary: A highly accurate DHA-licensed genetic test for diagnosing pathogenic TTBK2 variants causing autosomal dominant spinocerebellar ataxia type 11 (SCA11). Using next‑generation sequencing (NGS) in an ISO 9001:2015 accredited facility, we deliver 99.9% diagnostic sensitivity. Our service includes VIP mobile phlebotomy for home collection and post‑test clinical guidance from a Consultant Medical Genetics.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (available daily 8 AM–11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance for result interpretation by a DHA‑licensed Consultant Medical Genetics.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 731.
Test Overview & Methodology
The TTBK2 gene test employs next‑generation sequencing (NGS) to identify pathogenic variants responsible for autosomal dominant spinocerebellar ataxia type 11 (SCA11). This advanced genomic analysis provides definitive molecular diagnosis, differentiates SCA11 from other cerebellar ataxias, and enables family risk assessment. Full gene coverage and copy number variant (CNV) detection are included, with results reported per ACMG guidelines.
| Feature | Our NGS Test | Closest Alternative (Single Gene Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity/specificity | ~99% but may miss large deletions/duplications |
| Method | Next‑Generation Sequencing (NGS) with full gene coverage & CNV detection | Sanger sequencing limited to coding exons only |
| Turnaround Time | 3‑4 Weeks | 4‑6 Weeks |
| Sample Requirements | Whole blood, DNA, or FTA card | Whole blood or DNA only |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics at DNA Labs UAE, I emphasize that the TTBK2 NGS test provides highly accurate molecular data for SCA11. However, the result must be interpreted in the context of the patient’s clinical presentation and family pedigree. Genetic counseling before and after testing is essential for understanding implications, discussing reproductive options, and planning long‑term surveillance.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory
Do not discontinue any prescribed medication without consulting your doctor. This test does not replace a comprehensive neurological evaluation or existing treatment plan.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Not recommended for asymptomatic minors without documented family history and formal genetic counseling; results must be interpreted by a qualified physician.
- Exclusion: Patients on anticoagulation therapy (e.g., warfarin) should inform the phlebotomist before blood collection.
- Red Flag: If you experience sudden worsening of balance, difficulty swallowing, or seizures while awaiting results, seek immediate emergency medical care.
Patient FAQ & Clinical Guidance
1. How accurate is the TTBK2 NGS test for diagnosing spinocerebellar ataxia type 11?
A: The test achieves over 99.9% analytical sensitivity and specificity for detecting TTBK2 pathogenic variants when performed in our ISO 9001:2015 accredited facility. We use advanced bioinformatics to capture single‑nucleotide variants, small insertions/deletions, and copy number changes, with results confirmed by orthogonal methods and reported according to ACMG guidelines.
2. What sample is required and how is the home collection service arranged?
A: We accept a simple blood draw, extracted DNA, or a dried blood spot on an FTA card. VIP mobile phlebotomy is available daily from 8 AM to 11 PM across the UAE. Our ISO‑certified cold‑chain logistics ensure sample stability until it reaches our central laboratory. You can schedule via WhatsApp and receive pre‑test instructions from our team.
3. What does a positive or negative result mean for my family and future health?
A: A positive result confirms an autosomal dominant TTBK2 mutation, meaning each child has a 50% risk of inheriting SCA11. A negative result reduces but does not eliminate risk if other genes are involved. Pre‑ and post‑test genetic counseling is essential to understand the implications, discuss reproductive options, and plan long‑term neurological surveillance.
4. How will I receive my results and is my data kept private?
A: Results are delivered via a secure digital report within 3–4 weeks. All personal health information is protected under UAE Federal Decree‑Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019 concerning the use of ICT in health fields. Your data is encrypted and accessible only to authorized clinical staff.
UAE Regulatory & Data Privacy Adherence
Compliance Assurance: This genetic test is performed at a DHA‑licensed facility (License No. 1143) and adheres to the strictest UAE data protection laws:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- ISO 9001:2015 Certified (Cert. INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | TTBK2 Gene Spinocerebellar Ataxia Type 11, Autosomal Dominant Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood, DNA, or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) with full gene coverage & CNV detection |
| ICD-10-CM Code | G11.2 |
| LOINC Code | 95134-8 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab Branding: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians