Test Price
2,800 AED✅ Home Collection Available
THBD Gene Hemolytic Uremic Syndrome Genetic Test in UAE – 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Precision & Accuracy
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Sequencing (Cert: INT/EGQ/2509DA/3139). Every variant confirmed using validated clinical bioinformatic pipelines.
VIP Mobile Phlebotomy & Cold-Chain Home Collection
Available daily from 8 AM to 11 PM. Whole blood, extracted DNA, or FTA card accepted. Temperature-controlled transport ensures sample integrity. TAT: 3–4 weeks.
Post‑Test Clinical Guidance
Complimentary 15‑minute telehealth result interpretation with a DHA‑licensed genetic counsellor. No additional charge.
Insurance & Direct Verification
WhatsApp +971 54 548 8731 for instant direct‑billing check against your policy before collection.
The THBD gene test is a single‑visit comprehensive next‑generation sequencing analysis of the thrombomodulin gene to detect pathogenic variants linked to atypical hemolytic uremic syndrome (aHUS). This test aids nephrologists, medical geneticists, and general physicians in confirming a molecular diagnosis, enabling targeted anti‑complement therapies and family cascade screening.
Test Overview & Methodology
The THBD Gene Hemolytic Uremic Syndrome Genetic Test is a comprehensive next‑generation sequencing analysis of the thrombomodulin gene (THBD) to detect pathogenic variants linked to atypical hemolytic uremic syndrome (aHUS). This test aids nephrologists, medical geneticists, and general physicians in confirming a molecular diagnosis, enabling targeted anti‑complement therapies and family cascade screening. The protocol aligns with UAE federal genomic testing standards.
| Feature | Our Test (DHA‑Licensed) | Closest Alternative (e.g., Panel) |
|---|---|---|
| Methodology | Full‑gene NGS with copy‑number analysis (CNV detection) | Gene‑targeted Sanger sequencing or limited panel |
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | ~99.5% (Sanger); lower for panels without CNV integration |
| Turnaround Time | 3–4 weeks (cold‑chain logistics ensured) | 4–6 weeks (often without home collection) |
| UAE Regulatory Compliance | Full DHA/MOHAP genomic testing license, ISO 9001:2015 | Variable; may lack local accreditation |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics with extensive experience in inherited kidney disorders, I emphasise that a positive THBD variant must always be correlated with clinical findings, complement biomarkers, and renal function tests. This genetic test is a powerful diagnostic adjunct when interpreted by a qualified nephrologist or clinical geneticist. Never disregard your doctor’s treatment plan based solely on genetic results.”
Reviewed by Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Medication Advisory
⚠️ Do not discontinue prescribed medication (e.g., eculizumab, antihypertensives) without consulting your treating physician. This genetic test informs, not replaces, clinical management.
Exclusion Criteria & Emergency Red Flags
- Active acute hemolysis with rapid dropping hemoglobin – seek immediate emergency care.
- Platelet count < 50,000/µL or new onset neurological symptoms (confusion, seizures) – defer collection until stabilized.
- Current double antiplatelet therapy – discuss temporary hold with ordering clinician before DNA collection from FTA card (affects blood volumes).
- Age < 13 years requires a court‑appointed guardian’s consent in compliance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What exactly does the THBD genetic test detect, and why might I need it?
This test sequences the entire THBD gene to identify variants that cause thrombomodulin deficiency, a major trigger of atypical hemolytic uremic syndrome (aHUS) in children and adults. It helps determine if your unexplained kidney failure, microangiopathic hemolytic anemia, or familial history of HUS has a genetic origin, guiding life‑saving complement‑inhibiting therapy and allowing relatives to be screened.
2. Is home sample collection safe and valid for this test?
Yes, our DHA‑certified phlebotomists follow strict cold‑chain protocols using ISO‑certified transport kits, and a single drop of blood on an FTA card or a whole blood tube is fully sufficient for high‑quality DNA extraction. The FTA card method has been validated in our laboratory pipeline, providing identical diagnostic performance to standard venipuncture. Insurance often covers the nursing visit; confirm via WhatsApp.
3. How will my genetic data be protected under UAE law?
Your sample and report are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, together with our ISO 9001:2015 information security modules. Data is pseudonymized upon accessioning, stored on encrypted servers within the UAE, and never shared with third parties without explicit, revocable consent. Genetic counselling before testing explains all rights.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
This test is performed under the regulatory oversight of the Dubai Health Authority (DHA) and complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
- ISO 9001:2015 Quality Management System (Cert: INT/EGQ/2509DA/3139)
All genetic data is processed, stored, and transmitted using UAE‑based encrypted infrastructure. Patients retain the right to access, rectify, and withdraw consent at any time.
Clinical & Logistical Metadata
| Test Name | THBD Gene Hemolytic Uremic Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) with CNV detection |
| ICD-10-CM Code | D59.39, Z15.89, N17.9 |
| LOINC Code | 21683-2 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians