Test Price
2,800 AED✅ Home Collection Available
SP110 Gene Hepatic Veno-Occlusive Disease with Immunodeficiency Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing, ensuring exhaustive coverage of the SP110 gene.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) across all Emirates.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance in result interpretation with a DHA-licensed clinical specialist.
- Insurance: Direct Billing Verification available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SP110 Gene Hepatic Veno-Occlusive Disease with Immunodeficiency (VODI) NGS Test screens for pathogenic variants in the entire coding region of SP110 using Next‑Generation Sequencing. This advanced assay aids in diagnosing a rare combined immunodeficiency syndrome that predisposes individuals to hepatic veno‑occlusive disease and severe infections, enabling timely clinical intervention.
| Feature | Our Test (ISO‑Accredited) | Closest Alternative (Standard Panel) |
|---|---|---|
| Precision | Full gene sequencing & copy number analysis via NGS; >99.9% analytical sensitivity | Partial coverage / hotspot genotyping; ~93–97% sensitivity |
| Method | Next‑Generation Sequencing (Illumina NovaSeq) with Sanger validation | Targeted mutation panels or single‑exon Sanger |
| Turnaround | 3 to 4 Weeks (ISO 9001:2015 certified lab) | 4 to 8 Weeks (non‑prioritized) |
Physician Insight & Safety Protocols
Note from Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): “A positive SP110 result must be correlated with clinical hepatological and immunological findings. Genetic counselling is essential before and after testing, as VODI follows an autosomal recessive pattern and may necessitate family screening. False reassurance can arise from a negative result if a deep intronic or regulatory variant is not captured; continue monitoring if symptoms persist.”
Advisory on Medication Management
‼ Medication Safety Warning
Do not discontinue, adjust, or withhold any prescribed immunosuppressants, anticoagulants, or hepatoprotective medication without consulting your treating physician. Sudden cessation can provoke acute liver decompensation or profound immunodeficiency.
Exclusion Criteria & Emergency Red Flags
- Do not undergo testing if you have an active febrile illness or acute liver failure requiring hospitalization.
- Requires immediate DHA emergency room visit if you experience: acute onset of ascites, jaundice, unexplained high fever >39°C, or sudden hypoxia.
- Post-test: If you develop signs of portal hypertension (hematemesis, melena, abdominal distention) contact your hepatologist urgently.
Patient FAQ & Clinical Guidance
1. What exactly does the SP110 gene test detect, and why is it ordered?
Direct Answer: This NGS test identifies disease‑causing mutations in the SP110 gene that cause hepatic veno‑occlusive disease with immunodeficiency (VODI), a severe inherited disorder combining liver vein blockage and immune system failure. It is typically ordered by clinical geneticists or hepatologists when a patient presents with unexplained liver disease and recurrent infections in infancy or childhood.
2. How is the sample collected, and is home service available in Dubai and Abu Dhabi?
Direct Answer: We accept venous blood, extracted DNA, or a single drop of blood on an FTA card, collected by a DHA‑licensed phlebotomist during our premium home visit from 8 AM to 11 PM across all Emirates. For archived specimens such as FFPE tissue blocks, we offer secure medical courier solid tissue specimen retrieval instead of phlebotomy.
3. Why does the test take 3 to 4 weeks, and what happens after I receive the result?
Direct Answer: The exhaustive library preparation, sequencing, and multidisciplinary clinical annotation require 3–4 weeks; you then receive a comprehensive report and a tele‑counselling session with a genetic specialist to interpret the findings.
UAE Regulatory & Data Privacy Adherence
This laboratory service is provided in strict accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic counselling adheres to DHA-MOHAP guidelines. ISO 9001:2015 Certification: INT/EGQ/2509DA/3139.
Clinical & Logistical Metadata
| Test Name | SP110 Gene Hepatic Veno-Occlusive Disease with Immunodeficiency (VODI) NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq) with Sanger Confirmation |
| ICD-10-CM Code | D84.9 (Immunodeficiency, Unspecified) |
| LOINC Code | 81314-5 (SP110 gene full mutation analysis in Blood) |
| DHA Facility License & Laboratory Address Invariants | DHA Facility License No: 1143 – DNA Labs UAE Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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