Test Price
2,800 AED✅ Home Collection Available
SMAD2 Gene Sequencing for Thoracic Aortic Aneurysm & Dissection | Dubai, UAE | 2,800 AED
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO-certified Next Generation Sequencing (NGS) platform.
- Premium Logistics: VIP mobile phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Support: Post-test telephone interpretation consultation with a genetics specialist.
- Insurance: Direct coverage verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The SMAD2 gene sequencing test detects pathogenic and likely pathogenic variants associated with familial thoracic aortic aneurysm and dissection (TAAD), including Loeys-Dietz syndrome type 3. Positive findings guide prophylactic cardiovascular surveillance and surgical decision-making. Our service uses full gene sequencing by Next Generation Sequencing (NGS) with complete exon and splice-site coverage.
| Feature | Our SMAD2 NGS Test | Closest Alternative |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) – full gene analysis | Sanger sequencing (single exon only) |
| Turnaround Time | 3–4 Weeks | 6–12 Weeks |
| Clinical Depth | Complete exon & splice-site coverage | Limited to known familial mutation |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasise that a SMAD2 gene result must always be interpreted alongside detailed imaging and family history. A positive finding empowers early aneurysm monitoring, while a negative result never rules out all genetic aortopathies, so continued periodic echocardiographic surveillance remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Important Medication Notice
Do not discontinue any prescribed medication, especially beta‑blockers, angiotensin receptor blockers, or anticoagulants, without consulting your physician. Changes can precipitate acute aortic events.
Exclusion Criteria & Emergency Red Flags
- Not suitable for patients currently hospitalized with acute aortic dissection — call 998 immediately.
- Individuals who have not received pre‑test genetic counselling; a counselling session is mandatory under UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Minors require explicit parental consent in accordance with Federal Decree‑Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
If you experience sudden, severe chest or back pain, loss of consciousness, or stroke‑like symptoms, seek emergency care now.
Patient FAQ & Clinical Guidance
1. What does the SMAD2 genetic test actually detect?
SMAD2 sequencing identifies pathogenic mutations that cause familial thoracic aortic aneurysm and dissection, enabling early prophylactic surgery and tailored surveillance.
2. How long does it take to receive the result, and what does the price include?
Results are delivered in 3 to 4 weeks; the 2,800 AED covers hospital‑grade home blood collection, ISO‑certified cold‑chain logistics, and a dedicated post‑test clinical interpretation call.
3. Is this test right for me if no one in my family has had aortic problems?
Even without a family history, young individuals with unexplained aortic dilatation or bicuspid aortic valve may benefit from SMAD2 testing to uncover hidden aortopathy syndromes.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance
- All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information handling adheres to Federal Law No. 2 of 2019 on the Use of Information and Communication Technology in Health Fields.
- Clinical safety and consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory operations are ISO 15189 accredited and licensed by Dubai Health Authority (DHA) under facility license number 1143.
Clinical & Logistical Metadata
| Test Name | SMAD2 Gene Sequencing (Thoracic Aortic Aneurysm & Dissection) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Next Generation Sequencing (NGS) – full gene (exon & splice-site) analysis |
| ICD-10-CM Code | I71.2 (Thoracic aortic aneurysm without rupture), Z15.09 (Genetic susceptibility to other disease) |
| LOINC Code | 94037-6 (SMAD2 gene mutation analysis in Blood by NGS) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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