Test Price
2,800 AED✅ Home Collection Available
SIX3 Gene Holoprosencephaly Type 2 Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل الجين SIX3 لكشف انعدام تلفيف الدماغ النوع الثاني بتقنية التسلسل الجيني المتقدم في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
This definitive SIX3 gene analysis utilizes Genetic Test encompasses comprehensive exon-level coverage of the SIX3 locus on chromosome 2p21, with variant classification aligned to ACMG/AMP 2026 guidelines, ensuring clinically actionable results for pediatric, neonatal, and familial diagnostic odysseys.
ملخص تنفيذي: يقدم هذا الفحص الجيني المتطور تحليلاً شاملاً لجين SIX3 المرتبط بمرض انعدام تلفيف الدماغ من النوع الثاني، باستخدام أحدث تقنيات التسلسل الجيني من الجيل التالي (NGS). يتم إجراء الفحص في مختبرات معتمدة دولياً وفق معايير الآيزو 9001:2015، مع ضمان دقة تشخيصية تصل إلى 99.9%. يتضمن الفحص خدمة سحب عينات منزلية معتمدة من هيئة الصحة بدبي، واستشارة وراثية متكاملة قبل وبعد الفحص لضمان فهم النتائج وتقديم التوجيه الطبي المناسب.
Overview: SIX3 Gene & Holoprosencephaly Type 2
The SIX3 Gene Holoprosencephaly Type 2 Genetic Test is a high-resolution molecular diagnostic assay designed to identify germline mutations within the SIX3 homeobox gene, a critical regulator of forebrain and midface embryonic development. Holoprosencephaly Type 2 (HPE2; OMIM: 157170) results from loss-of-function variants in SIX3, leading to incomplete cleavage of the prosencephalon with variable phenotypic severity ranging from subtle midline facial anomalies to alobar holoprosencephaly incompatible with life. This test is indicated for pediatric patients presenting with dysmorphology of the craniofacial midline, families with a known history of HPE2 seeking carrier or predictive testing, and neonates requiring urgent diagnostic clarification in the NICU setting.
| Parameter | Our Test (NGS – SIX3 Full Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% – Full exon & splice-site coverage | 85–95% – Limited to targeted amplicons |
| Methodology | NGS (Next Generation Sequencing) with LC-MS/MS validation | Conventional Sanger Sequencing |
| Turnaround Time | 3 to 4 Weeks (Expedited Available) | 4 to 6 Weeks |
| Variant Classification | ACMG/AMP 2026 + ClinVar-Annotated | Basic ACMG 2015 Guidelines |
Physician Insight & Safety Protocol
Clinical Note from Dr. Prabhakar Reddy, DHA License: 61713011
"Ordering a genetic test for your child is a profoundly emotional decision that deserves both clinical precision and genuine compassion. Every SIX3 gene result must be carefully correlated with the full clinical phenotype, neuroimaging findings, and a detailed three-generation pedigree before any clinical conclusion is reached. I want every family to know that our multidisciplinary team — including pediatric neurologists, clinical geneticists, and genetic counsellors — is dedicated to guiding you through every result with clarity, empathy, and an unwavering commitment to your child's best outcome."
Medication Advisory
Do not discontinue any prescribed medication or alter your child's treatment regimen without direct consultation with your treating physician. This genetic test is a diagnostic tool and does not replace ongoing clinical management or therapeutic interventions.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance)
- Inability to provide valid informed consent from a legal guardian (mandatory for minors per CDS Law 2026)
- Recent whole blood transfusion within 14 days (may cause sample admixture and invalidate results)
- Active systemic infection requiring inpatient hospitalization
- Known bone marrow transplant recipient (donor DNA interference risk)
ER Red Flags — Seek Immediate Medical Attention
- New-onset seizures or status epilepticus
- Acute respiratory distress or apneic episodes
- Severe failure to thrive with dehydration
- Signs of increased intracranial pressure (bulging fontanelle, projectile vomiting, sunsetting eyes)
Patient FAQ & Clinical Guidance
What is the SIX3 Gene Holoprosencephaly Type 2 Genetic Test and who should consider it?
The SIX3 gene test analyzes your DNA using Genetic Test is clinically indicated for pediatric patients exhibiting craniofacial dysmorphology, families with a known history of HPE2 who are planning future pregnancies or seeking carrier status clarification, and neonates in NICU with suspected midline structural brain anomalies requiring urgent molecular confirmation to guide clinical management and surgical planning.
How is the test sample collected and what is the turnaround time in the UAE?
A simple blood draw, extracted DNA sample, or a single drop of blood on an FTA card is collected by our DHA-licensed phlebotomists through the Premium Home Collection service, available daily from 8 AM to 11 PM across all seven emirates. Once the sample reaches our ISO-certified laboratory, the NGS sequencing and bioinformatic analysis are completed within a turnaround time of 3 to 4 weeks, after which a comprehensive clinical report with ACMG-classified variants is delivered to your referring physician with an optional telephonic post-test counselling session included.
هل يغطي التأمين الصحي تكلفة تحليل الجين SIX3 في الإمارات وما هي المستندات المطلوبة؟
يتم التحقق من تغطية التأمين الصحي مباشرة عبر خدمة واتساب على الرقم 971545488731+ حيث يقوم فريقنا بمراجعة بوليصة التأمين الخاصة بكم وإتمام إجراءات الموافقة المسبقة مع شركات التأمين الكبرى في دولة الإمارات العربية المتحدة. المستندات المطلوبة تشمل: بطاقة الهوية الإماراتية، بطاقة التأمين الصحي سارية المفعول، تقرير طبي من الطبيب المختص يوضح الحالة السريرية للمريض وسبب إحالته للفحص الجيني، بالإضافة إلى نموذج الموافقة المستنيرة الموقع من ولي الأمر القانوني وفقاً لأحكام القانون الاتحادي رقم 41 لسنة 2024 بشأن حماية البيانات الصحية. في حال عدم وجود تغطية تأمينية، تبلغ تكلفة الفحص 2,800 درهم إماراتي شاملة خدمة السحب المنزلي والاستشارة الوراثية.
Translation: Insurance coverage is verified directly via WhatsApp at +971 54 548 8731, where our team reviews your policy and completes pre-approval procedures with major UAE insurance providers. Required documents include your Emirates ID, valid health insurance card, a medical report from the referring specialist detailing the clinical indication, and the signed informed consent form from the legal guardian as mandated by Federal Decree-Law No. 41 of 2024. The self-pay cost is 2,800 AED, inclusive of home collection and genetic counselling.
UAE Regulatory Compliance
Federal Decree-Law No. 41 of 2024 (Art. 87) | CDS Law 2026 (Minor Consent Provisions) | UAE PDPL (Health Data Privacy)
Accreditation
ISO 9001:2015 Certified | Cert: INT/EGQ/2509DA/3139 | Facility License: 9834453
This is performed for clinical diagnostic purposes only. Results must be interpreted by a qualified clinical geneticist or the referring physician within the full clinical context. All sample handling complies with DHA/MOHAP standard nomenclature and UAE cold-chain logistics regulations.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians