Test Price
2,800 AED✅ Home Collection Available
RTN2 Gene (SPG12) Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Counseling with a DHA-Licensed Genetic Counselor.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The RTN2 Gene (SPG12) Genetic Test examines the entire coding sequence of the reticulon 2 gene to identify pathogenic variants responsible for autosomal dominant hereditary spastic paraplegia type 12. Next‑Generation Sequencing (NGS) provides massively parallel analysis of all exons and intron‑exon boundaries, delivering >99.9% detection rate for single‑nucleotide variants, small insertions/deletions, and copy number changes.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (massively parallel) | Sanger sequencing (single‑target) |
| Detection Rate | >99.9% (full coding region + intron‑exon boundaries) | ~98% (limited to known hotspots) |
| Turnaround Time | 3–4 Weeks (ISO‑certified laboratory) | 6–8 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403) shares: “A diagnosis of hereditary spastic paraplegia often carries profound implications for the entire family. This NGS panel provides a definitive molecular answer, allowing us to offer targeted management, accurate recurrence risk counseling, and preimplantation genetic testing options. However, the result must always be integrated with a thorough neurological assessment and a detailed pedigree analysis. A positive finding is never a standalone endpoint—it is the beginning of a personalized care pathway.”
Advisory: Medication and Treatment Continuity
⚠️ Do Not Discontinue Prescribed Neurological or Anti-Spasticity Medication
Abruptly stopping any prescribed medication may lead to withdrawal symptoms or exacerbation of spasticity. Always consult your treating neurologist before making any changes. This genetic test does not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (<2 weeks) may interfere with germline DNA extraction; reschedule if possible.
- Active chemotherapy or bone marrow transplant within the last month – consult our genetic counsellor.
- Emergency Red Flags: Sudden inability to walk, acute respiratory difficulty, or severe spasticity crisis → proceed to the nearest emergency department before any scheduled genetic testing.
- Non‑invasive prenatal diagnosis or preimplantation genetic testing requires a separate, dedicated referral and is not covered under this standard NGS test.
Patient FAQ & Clinical Guidance
1. What exactly does the RTN2 gene NGS test detect?
RTN2 gene NGS testing identifies hereditary spastic paraplegia type 12 mutations with high diagnostic accuracy. The assay captures single‑nucleotide variants, small insertions/deletions, and copy number changes across the entire RTN2 coding region, providing a definitive molecular diagnosis for suspected autosomal dominant SPG12.
2. What sample type is required and how is it collected?
A single blood draw (3–5 mL in EDTA) or a dried blood spot on an FTA card suffices for testing. Our DHA‑licensed phlebotomist performs a painless home collection between 8 AM and 11 PM; samples travel in a validated cold‑chain transport to the genetic laboratory within hours. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available daily from 8 AM to 11 PM.
3. Does health insurance cover the RTN2 SPG12 NGS?
Most UAE insurance plans cover genetic testing for hereditary spastic paraplegia when medically justified by a neurologist. We verify your policy’s coverage directly via WhatsApp at +971 54 548 8731 before the blood draw, and we submit pre‑approvals with the required ICD‑10 codes G11.4 and Z15.89 on your behalf.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance: This test is conducted under the regulatory framework of the Dubai Health Authority (DHA Facility License: 1143). All genetic data is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your sample and results are protected by ISO 9001:2015 certified processes and encrypted storage.
Clinical & Logistical Metadata
| Test Name | RTN2 Gene (SPG12) Genetic Test – Next‑Generation Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – Massively Parallel Sequencing of Full Coding Region + Intron‑Exon Boundaries |
| ICD‑10‑CM Code | G11.4, Z15.89 |
| LOINC Code | 21665-1 |
| DHA Facility License & Laboratory Address | License No: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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