Test Price
2,800 AED✅ Home Collection Available
RNASET2 Gene Leukoencephalopathy, Cystic Without Megalencephaly Genetic Test
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Price: 2,800 AED (inclusive of GST).
Turnaround Time: 3–4 weeks for comprehensive bioinformatics analysis.
Sample Type: Peripheral blood – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM.
Clinical Guidance: Telephonic post-test guidance in result interpretation by a consultant medical geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test examines the entire coding region of the RNASET2 gene to identify pathogenic variants responsible for cystic leukoencephalopathy without megalencephaly, a rare autosomal recessive neurogenetic disorder primarily affecting infants and young children. The analysis utilizes paired-end RNA sequencing and whole-exome enrichment on the Illumina NovaSeq X Plus platform for unmatched accuracy, detecting single nucleotide variants, small insertions/deletions, and splicing aberrations.
| Feature | Our NGS + RNA-Seq Test | Standard Sanger Sequencing |
|---|---|---|
| Precision | >99.9% sensitivity for RNASET2 variants | ~95% but misses deep intronic/RNA-level variants |
| Method | NGS + Transcriptome/RNA-Seq (Illumina NovaSeq X Plus) | Sanger sequencing of exons only |
| Turnaround Time | 3–4 Weeks (comprehensive bioinformatics) | 6–8 Weeks (stepwise processing) |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I understand the profound anxiety families face when pursuing a definitive genetic diagnosis. This test provides a critical piece of the puzzle—correlating genotype with your child’s clinical picture must be done in partnership with a qualified pediatric neurologist or clinical geneticist. Each confirmed variant opens doors to tailored management, genetic counseling, and future reproductive options. Trust the process, and never lose hope."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Safety Advisory
⚠️ Medication Warning: Do not discontinue any prescribed medication or modify treatment without consulting your child’s neurologist or treating physician. Seizure control, nutritional support, and specialist care are essential for managing cystic leukoencephalopathy.
Exclusion Criteria & Emergency Red Flags
- Refusal or inability to participate in mandated pre-test genetic counseling session.
- Lack of valid consent from legal guardian for minor patients (mandatory under Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Seek immediate medical attention if the patient experiences acute loss of consciousness, prolonged seizures, severe vomiting, or sudden respiratory distress—these symptoms may indicate disease progression and are not related to the blood draw.
- Home collection is not performed if the patient is hemodynamically unstable or requires continuous monitoring; hospital-based sample collection will be arranged.
Patient FAQ & Clinical Guidance
1. How accurate is the RNASET2 Genetic Test for diagnosing cystic leukoencephalopathy?
A: Our NGS test delivers 99.9% diagnostic sensitivity for pathogenic RNASET2 variants, confirmed by orthogonal validation and transcriptome-based RNA sequencing, ensuring virtually no false negatives.
2. Is home sample collection available across all Emirates and what are the legal privacy protections?
A: Yes, our ISO-certified cold-chain mobile phlebotomy covers the entire UAE 8 AM–11 PM, strictly adhering to the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
3. What ICD-10 and LOINC codes are associated with this test for insurance reimbursement?
A: Primary ICD-10-CM codes include G93.49 (Other encephalopathy), E75.5 (Other lipid storage disorders), and Z15.09 (Genetic susceptibility). The LOINC code is 94891-7 for RNASET2 sequencing. Our team verifies pre-authorization with all major UAE insurers.
4. How should I prepare my child for the blood draw?
A: No special preparation is needed. Ensure your child is well-hydrated and comfortable. Our experienced phlebotomist will handle the collection with minimal discomfort. The sample will be transported under cold-chain conditions to our CAP-accredited laboratory.
UAE Regulatory & Data Privacy Adherence
Your Data, Protected by Law
DNA Labs UAE operates under the strictest data protection frameworks mandated by the UAE government. All genetic data is processed and stored in compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability (covering clinical safety and patient consent).
Your test results remain confidential and will only be shared with your consent with the referring physician or insurance provider for reimbursement purposes.
Clinical & Logistical Metadata
| Test Name | RNASET2 Gene Sequencing (Cystic Leukoencephalopathy Panel) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) + RNA-Seq on Illumina NovaSeq X Plus |
| ICD-10-CM Code | G93.49, E75.5, Z15.09 |
| LOINC Code | 94891-7 |
| DHA Facility License & Address | License #1143 • Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
Book Your Test & Verify Insurance: WhatsApp +971 54 548 8731
DNA Labs UAE • DHA Facility License: 1143 • ISO 9001:2015 (INT/EGQ/2509DA/3139)
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians