Test Price
2,800 AEDโ Home Collection Available
RAB3GAP2 Gene (Warburg Micro Syndrome Type 2) NGS Test in UAE โ 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
This Next-Generation Sequencing (NGS) test delivers definitive molecular confirmation for Warburg Micro Syndrome Type 2 (WARBM2) through comprehensive analysis of the RAB3GAP2 gene. Designed for paediatric dysmorphology evaluations, the assay provides 99.9% diagnostic sensitivity for single-nucleotide variants and small insertions or deletions.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post-test interpretation by our DHA-licensed Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Turnaround Time: 3โ4 weeks (standard) from sample receipt in the laboratory.
Test Overview & Methodology
The RAB3GAP2 gene encodes a subunit of the Rab3 GTPase-activating protein complex, essential for intracellular vesicle trafficking. Pathogenic variants in RAB3GAP2 cause Warburg Micro Syndrome Type 2 (OMIM #614225), a severe autosomal recessive neurodevelopmental disorder characterised by congenital microcephaly, ocular abnormalities (microphthalmia, cataracts, retinal dystrophy), hypogenitalism, and profound developmental delay. This test utilises targeted next-generation sequencing (NGS) with Sanger confirmation to interrogate all coding exons and flanking intronic regions of the gene, delivering a definitive molecular diagnosis for at-risk families in the UAE.
| Feature | Our NGS Test (DNA Labs UAE) | Alternative Single-Gene Sequencing |
|---|---|---|
| Precision | 99.9% sensitivity for SNVs and small indels across the entire RAB3GAP2 gene | 90โ95% sensitivity, often missing deep intronic variants |
| Method | NGS with targeted capture and Sanger confirmation | Sanger sequencing of selected exons only |
| Speed | Results in 3โ4 weeks | 4โ6 weeks, with higher re-test rates |
Physician Insight & Safety Protocols
โConfirming a diagnosis of Warburg Micro Syndrome Type 2 through precise molecular testing is critical for guiding family counselling, early intervention planning, and prognostication. This NGS assay provides the genetic evidence required to distinguish WARBM2 from other microcephaly syndromes, yet results must always be interpreted alongside clinical findings and, where appropriate, segregation analysis in first-degree relatives. Pre-test genetic counselling remains a mandatory prerequisite to ensure informed consent and comprehensive pedigree documentation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Pre-Test Preparation & Medication Stability
Maintain all prescribed medications unless explicitly directed otherwise by your treating physician. The testing process does not require alteration of ongoing therapies. If the patient experiences new-onset seizures, severe feeding difficulties, or respiratory distress before sample collection, seek immediate emergency care and postpone the blood draw until clinical stability is restored.
Exclusion Criteria & Emergency Red Flags
- Patient must be clinically stable; acute febrile illness or uncontrolled infection may delay collection.
- Recent blood transfusion (< 2 weeks) can confound DNA extraction from whole blood; a buccal swab or archived specimen may be used as an alternative.
- ER Red Flags: If your child develops new-onset seizures, severe feeding difficulties, or breathing irregularities before sample collection, proceed to the nearest emergency department immediately and contact our clinical team for rescheduling.
Patient FAQ & Clinical Guidance
1. What is the RAB3GAP2 gene test and why is it recommended?
This genetic test identifies pathogenic variants in the RAB3GAP2 gene, confirming Warburg Micro Syndrome Type 2, a rare neurodevelopmental disorder marked by microcephaly, ocular anomalies, and hypogenitalism. Clinicians recommend it when a child presents with dysmorphic features and severe developmental delay, especially in families with a history of consanguinity. The test provides definitive molecular evidence to guide early intervention and reproductive counselling.
2. How is the sample collected and what is the turnaround time?
A simple peripheral blood draw (or an alternative specimen such as a buccal swab or extracted DNA) is required. Our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service is available daily from 8 AM to 11 PM. Once the sample reaches the laboratory, the standard turnaround time is 3 to 4 weeks. Pre-test genetic counselling is mandatory to obtain informed consent and document the family pedigree.
3. What do the results mean for my child and family?
A positive result confirms the diagnosis of Warburg Micro Syndrome Type 2, enabling a multidisciplinary care plan that includes early vision intervention, developmental therapies, and family genetic counselling for future pregnancies. A negative result reduces the likelihood of WARBM2 but does not rule out other genetic syndromes affecting neurodevelopment. Your DHA-licensed consultant medical geneticist will interpret all findings within the context of the clinical presentation and, when indicated, recommend further genomic testing.
4. Is pre-test genetic counselling mandatory?
Yes. Federal Decree-Law No. 4 of 2016 on Medical Liability mandates that informed consent must be obtained after the patient or guardian receives a clear explanation of the test scope, limitations, and potential implications. Our genetics team provides this counselling at no additional cost prior to sample collection.
5. Can the test be performed if my child has had a blood transfusion recently?
A recent transfusion (within two weeks) may confound DNA extraction from whole blood. In such cases, we recommend using a buccal swab or an archived tissue specimen after consulting with our clinical team. The laboratory will advise on the most appropriate specimen type for your specific situation.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
DNA Labs UAE complies with all applicable UAE federal laws governing the collection, storage, and processing of genetic and health data. Patient information is handled under:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): ensures that your genetic data is collected only with explicit consent, used solely for diagnostic purposes, and stored with robust technical safeguards.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: governs the electronic transmission and storage of health records, including genomic data, to maintain confidentiality and integrity.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: establishes the legal framework for clinical practice, including the obligation to obtain fully informed consent before any genetic testing procedure and to respect patient autonomy throughout the diagnostic process.
All results are disclosed only to the referring physician and the patient or legal guardian. No third-party access is permitted without written authorisation. Our laboratory maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and adheres to international standards for quality and data security.
Clinical & Logistical Metadata
| Test Name | RAB3GAP2 Gene (Warburg Micro Syndrome Type 2) โ NGS Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks (standard) from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA), buccal swab, or extracted DNA; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM |
| Methodology Used | Targeted NGS (whole coding region + flanking introns) with Sanger confirmation of all pathogenic and likely pathogenic variants |
| ICD-10-CM Code | Q87.8 (Other specified congenital malformation syndromes, not elsewhere classified) |
| LOINC Code | 77907-3 (Genetic analysis of specific gene) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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