Test Price
2,800 AED✅ Home Collection Available
RAB3GAP1 Gene Warburg Micro Syndrome Type 1 Genetic Test in UAE | 2800 AED | DHA-Licensed Molecular Diagnostics
Executive Summary & Core Metrics
Accuracy Guarantee:
- 99.9% Diagnostic Sensitivity via ISO-Accredited NGS Processing (Illumina NovaSeq Platform)
Premium Logistics:
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM)
- Secure Medical Courier for solid tissue or archival specimens when required
Clinical Guidance:
- Telephonic Post-Test Clinical Guidance for result interpretation and family planning
Insurance & Billing:
- Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
This comprehensive RAB3GAP1 gene analysis utilises high-coverage Next-Generation Sequencing to detect all pathogenic variants causing Warburg micro syndrome type 1, a severe neurodevelopmental disorder characterised by microcephaly, microphthalmia, and cerebral malformations. Results guide accurate diagnosis, family planning, and tailored neurological management.
The assay covers all coding exons, intron-exon boundaries, and known regulatory regions of the RAB3GAP1 gene. Variants are classified according to ACMG/AMP guidelines, providing a definitive molecular report for diagnostic or carrier testing.
| Feature | DNA Labs UAE | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing + CNV detection (99.9% analytical sensitivity) | Sanger sequencing of select exons (≈95% detection rate, misses large deletions) |
| Method | Next-Generation Sequencing (Illumina NovaSeq) with ACMG-guided variant classification | Single-gene Sanger sequencing |
| Speed | 3-4 Weeks | 6-8 Weeks (often multi-step) |
Physician Insight & Safety Protocols
"Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), shares: 'As a clinician dedicated to rare neurodevelopmental disorders, I understand the immense worry families face. This genetic test offers definitive molecular confirmation, yet every result must be correlated with the child's clinical picture and detailed family history. A multidisciplinary team, including genetic counselling, is essential to translate the findings into a compassionate, personalised care plan.'"
Medication Advisory
Important: Do not discontinue any prescribed medication without consulting your doctor. Genetic testing does not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Patients with severe bleeding disorders must obtain specialist clearance before blood collection.
- FTA card sample is not recommended if extracted DNA quantity is insufficient; whole blood (EDTA) is preferred.
- Minors require documented parental consent in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ER Red Flags: Seek immediate medical attention if the patient experiences acute neurological deterioration, prolonged seizures, or sudden loss of consciousness unrelated to sample collection.
All procedures adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Patient FAQ & Clinical Guidance
1. What is the RAB3GAP1 gene and Warburg micro syndrome type 1?
Quick Answer: The RAB3GAP1 gene provides instructions for a protein essential for normal brain and eye development; pathogenic variants cause Warburg micro syndrome type 1, a severe congenital disorder marked by microcephaly, microphthalmia, and cerebral malformations.
This autosomal recessive condition often presents in infancy with profound developmental delay, vision loss, and characteristic facial features. Molecular diagnosis enables accurate genetic counselling and early intervention planning.
2. How accurate is this NGS test and what does it detect?
Quick Answer: This assay achieves 99.9% analytical sensitivity for single nucleotide variants, small insertions/deletions, and copy number changes across the entire RAB3GAP1 gene.
It covers all coding exons, intron-exon boundaries, and known regulatory regions. Variants are classified according to ACMG/AMP guidelines, providing a definitive molecular report for diagnostic or carrier testing.
3. How should I prepare for the test, and what do results mean?
Quick Answer: No dietary or medication changes are required before sample collection; however, a mandatory pre-genetic counselling session must be completed to draw a detailed pedigree and discuss implications.
Results indicate whether disease-causing variants are present. A positive finding confirms the diagnosis and enables carrier testing for relatives; a negative result reduces the likelihood but does not rule out other genetic disorders.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Compliance
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – patient data confidentiality and processing safeguards.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – secure handling of electronic health records.
- ISO 9001:2015 Certified Laboratory (Cert: INT/EGQ/2509DA/3139) – all processes comply with DHA/MOHAP standards.
Support & Booking: +971 54 548 8731 (WhatsApp) | Home collection available daily 8 AM – 11 PM | Insurance verification via WhatsApp
Clinical & Logistical Metadata
| Test Name | RAB3GAP1 Gene Warburg Micro Syndrome Type 1 Genetic Test (Next-Generation Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM) |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) with ACMG/AMP-classified variant interpretation |
| ICD-10-CM Code | Q87.8 (Warburg micro syndrome) |
| LOINC Code | 94252-9 (Genetic analysis of a single gene using NGS) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians