Test Price
2,800 AED✅ Home Collection Available
PROK2 Gene Kallmann Syndrome Type 4 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary
- Accuracy Guarantee: 99.9% diagnostic sensitivity for pathogenic variants in the PROK2 gene, performed under ISO 9001:2015 certified processing.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM, 7 days a week.
- Clinical Guidance: Telephonic post-test counselling with a Consultant Medical Geneticist to interpret results and plan next steps.
- Insurance: Direct billing verification and pre-approval support via WhatsApp +971 54 548 8731.
DHA Facility License: 1143 | Corporate Lab: DNA Labs UAE
Test Overview & Methodology
The PROK2 Gene Kallmann Syndrome Type 4 NGS Test identifies DNA sequence variants in the PROK2 gene responsible for hypogonadotropic hypogonadism and absent sense of smell (anosmia). This next-generation sequencing assay delivers definitive molecular confirmation of Kallmann syndrome type 4, guiding hormone replacement therapy and reproductive planning. The assay covers the entire coding region plus exon-intron boundaries, ensuring detection of both point mutations and small deletions.
| Feature | Our Test (PROK2 Gene NGS) | Closest Alternative (Hormonal Panel) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for exon-level mutations | ~60–70% (phenotypic overlap with other hypogonadism) |
| Methodology | Next-Generation Sequencing (NGS) with copy number analysis | Serum LH, FSH, testosterone/estradiol immunoassay |
| Clinical Turnaround | 3–4 Weeks with detailed molecular report | Same-day results, but no genetic aetiology |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I understand that the journey to a diagnosis for delayed puberty and anosmia can be lengthy and uncertain. The PROK2 gene test provides a definitive molecular explanation for many patients, enabling precise hormonal management and informed family planning. Every result must be interpreted within the full clinical context, and I am committed to supporting you through pre- and post-test genetic counselling.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication Continuity
Important Clinical Advisory
Do not discontinue any prescribed hormonal therapy or other medication without consulting your doctor. Genetic test results may inform future treatment adjustments, but abrupt cessation of therapy can pose significant health risks.
Exclusion Criteria & Emergency Red Flags
- Active fever, severe infection, or haemodynamic instability precludes routine blood collection.
- Known severe anaemia (Hb <7 g/dL) or bleeding diathesis – contact our medical team for clearance.
- Lack of informed consent or valid genetic counselling documentation (mandatory per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Seek emergency care if after sample collection you develop: sudden loss of vision, intense headache, chest pain, or fainting. These are rare but require immediate attention.
Patient FAQ & Clinical Guidance
1. What exactly does the PROK2 gene test detect, and how is it related to Kallmann syndrome type 4?
This Next-Generation Sequencing test identifies mutations in the PROK2 gene, which are directly responsible for Kallmann syndrome type 4 – a congenital disorder causing delayed or absent puberty and anosmia. Because the condition is often misdiagnosed as simple constitutional delay, molecular confirmation is essential. The assay covers the entire coding region plus exon-intron boundaries, ensuring detection of both point mutations and small deletions. A pre-test genetic counselling session is mandatory to construct a pedigree and discuss the inheritance pattern.
2. How is the sample collected for this genetic test, and what are the exact requirements?
A trained DHA-licensed phlebotomist collects a standard whole blood sample, extracted DNA, or a single drop of blood on an FTA card during a scheduled home visit. No fasting or special preparation is needed, and the entire process takes less than 10 minutes. For infants or young children, we offer a specialised paediatric pain-management protocol. All samples are transported at controlled temperature (2–8 °C) to our ISO-accredited facility immediately after collection.
3. What is the turnaround time and cost for the PROK2 gene test in the UAE, and does insurance cover it?
Results are typically delivered within 3 to 4 weeks from sample receipt, with a total price of 2800 AED inclusive of genetic counselling and phlebotomy fees. We verify insurance coverage upfront via WhatsApp (+971 54 548 8731) and assist with direct billing to most major UAE insurers. Please note that co-payments may apply depending on your policy; our team will confirm all financial details before the test.
4. Who will interpret my genetic test results and provide counselling?
Your results are reviewed and interpreted by a Consultant Medical Geneticist (Lina Osama Zaki Quteineh, DHA Registration ID: 9294403) who specialises in reproductive genetics. A comprehensive written molecular report is provided, followed by a telephonic counselling session to explain the findings, discuss inheritance risks, and outline recommended next steps for clinical management or family planning.
UAE Regulatory & Data Privacy Adherence
Compliance: This test is conducted in full accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility holds ISO 9001:2015 certification and operates under DHA Facility License No. 1143. Patient data is encrypted and stored within secure UAE-based servers; explicit informed consent is obtained prior to any genetic analysis.
Clinical & Logistical Metadata
| Test Name | PROK2 Gene Kallmann Syndrome Type 4 NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card blood spot |
| Methodology Used | Next-Generation Sequencing (NGS) with copy number analysis |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 55233-1 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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