Test Price
2,800 AED✅ Home Collection Available
ORC1 Gene Meier-Gorlin Syndrome Type 1 Genetic Test | 2800 AED | Expert Genetics Assessment
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Regulatory Compliance: Fully compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability.
Test Overview & Methodology
The ORC1 gene test uses Next-Generation Sequencing to detect pathogenic variants linked to Meier-Gorlin syndrome type 1, aiding clinical diagnosis for dysmorphology in children and adults.
| Feature | Our Test (ORC1 NGS) | Closest Alternative (Broad Dysmorphology Panel) |
|---|---|---|
| Precision | Targeted deep sequencing with >100x coverage for ORC1 gene, including regulatory regions | Variable coverage; may miss deep intronic or regulatory variants |
| Method | Next Generation Sequencing (Illumina) with Sanger validation | NGS panel, often limited to exonic regions |
| Turnaround Time | 3–4 Weeks | 4–8 Weeks |
| Interpretation | Expert geneticist-reviewed, Meier-Gorlin-focused | General dysmorphology report; may not highlight ORC1-specific findings |
Physician Insight & Safety Protocols
Every child is unique, and this test provides a molecular diagnosis to guide care and family planning. A negative result does not rule out a clinical diagnosis; always correlate with physical findings and specialist evaluation. We support you with compassionate, DHA-licensed post-test counseling.
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria
- Recent blood transfusion (within 2 weeks) or bone marrow transplant may interfere with germline DNA analysis.
- Not suitable for standalone prenatal diagnosis without amniocentesis and full genetic counseling.
- Patients with hematopoietic stem cell therapy should delay testing for at least 6 weeks.
Emergency Red Flags
Seek immediate medical attention if the patient develops new-onset seizures, severe feeding difficulties, respiratory distress, or sudden loss of developmental milestones.
Patient FAQ & Clinical Guidance
1. What is the clinical indication for the ORC1 gene test?
Our ORC1 NGS test detects pathogenic mutations causing Meier-Gorlin syndrome type 1 to confirm clinical diagnosis in children with microcephaly, patellar aplasia, and short stature. The test is indicated when a physician suspects the syndrome based on characteristic dysmorphic features and aims to differentiate it from other growth-related disorders.
2. How is the test performed and what sample is needed?
The test requires a blood sample (whole blood or FTA card) or extracted DNA, processed by next-generation sequencing with a turnaround time of 3–4 weeks. A certified phlebotomist collects the sample through our VIP home collection service, ensuring cold-chain transport to the ISO-accredited laboratory.
3. Is genetic counseling required before and after testing?
Pre- and post- genetic counseling is mandatory to interpret results, construct a pedigree, and discuss implications for family members. A DHA-licensed genetic counselor will guide you through the informed consent process and explain potential outcomes, including variants of uncertain significance.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143. All genetic data is processed in compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent is obtained per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ORC1 Gene Meier-Gorlin Syndrome Type 1 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | Next Generation Sequencing (Illumina) with Sanger validation |
| ICD-10-CM Code | Q87.1 |
| LOINC Code | 81247-9 |
| DHA License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians