Test Price
2,800 AED✅ Home Collection Available
NSMF Gene Hypogonadotropic Hypogonadism Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Sequencing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily 8 AM to 11 PM across all Emirates.
Clinical Guidance: Telephonic Post-Test Genetic Counselling to interpret results within 3–4 Weeks.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 – all major UAE insurers accepted.
Test Overview & Methodology
The NSMF gene sequencing test detects pathogenic variants in the NSMF (NMDA receptor synaptonuclear signaling and neuronal migration factor) gene, which are causative for congenital hypogonadotropic hypogonadism (CHH) – a condition marked by failed pubertal development, absent or incomplete sexual maturation, and infertility due to deficient GnRH secretion. This Next-Generation Sequencing (NGS) assay provides full-gene coverage with >100x depth, detecting single nucleotide variants, insertions/deletions, and copy number variations.
| Feature | Our NSMF NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Full-gene coverage with >100x depth, detects SNVs, indels, CNVs | Targeted exon analysis only, may miss deep intronic variants |
| Methodology | Next Generation Sequencing (Illumina) – Gold Standard | Capillary Sequencing (Sanger) – Limited scope |
| Turnaround Time | 3–4 Weeks from sample receipt | Often 6–8 Weeks with batch processing |
| Sample Collection | VIP Home Phlebotomy – Free cold-chain collection | Hospital visit required; limited home service with extra cost |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I understand the anxiety that accompanies a search for answers in delayed puberty or infertility. This test provides molecular clarity, but it must be interpreted alongside your endocrine profile and family history. I strongly advise that any management changes be discussed with your referring endocrinologist.” – Lina Osama Zaki Quteineh, DHA Registration ID: 9294403
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (within 2 weeks) may interfere with germline DNA analysis and is an exclusion criterion.
- This test is not validated for somatic mosaicism detection; if clinical suspicion of mosaicism, inform our laboratory before ordering.
- If the patient presents with severe acute pubertal arrest, olfactory dysfunction (anosmia/hyposmia), or sudden vision changes, seek immediate endocrinology/neurology evaluation before genetic testing.
- A positive NSMF variant requires urgent genetic counseling for family planning and cascade screening of at-risk relatives.
Advisory Note
All clinical decisions based on this test must be made in consultation with your healthcare provider. This test does not replace clinical evaluation or imaging studies.
Patient FAQ & Clinical Guidance
1. What is the NSMF gene test used for, and who should consider it?
The NSMF gene sequencing test diagnoses congenital hypogonadotropic hypogonadism (CHH) by detecting disease-causing mutations. It is indicated for patients with absent/delayed puberty, amenorrhea in females, small testes in males, and infertility of unknown origin. This test provides a molecular confirmation essential for guiding lifelong hormone replacement therapy and family planning. Individuals with a family history of Kallmann syndrome or unexplained CHH benefit most.
2. How is the test performed, and what is the turnaround time?
A simple blood draw is collected at your home by our ISO-certified cold-chain phlebotomy team and shipped immediately to our Dubai laboratory. Results are ready in 3–4 weeks, with an optional expedited report for urgent clinical needs (prior coordination required). You will be contacted for a post-test teleconsultation with a genetic counselor to explain the findings.
3. Is the NSMF gene test covered by UAE insurance and compliant with regulations?
Yes, this test is fully DHA-compliant and covered by most major UAE health insurers. We verify direct billing on your behalf via WhatsApp +971 54 548 8731. Our laboratory adheres to all applicable data protection and health information security frameworks, ensuring your genetic data is stored securely and never shared without consent.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is encrypted, access-controlled, and never shared with third parties without your explicit authorization.
Clinical & Logistical Metadata
| Test Name | NSMF Gene Hypogonadotropic Hypogonadism Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina Platform |
| ICD-10-CM Code | E23.0 (Hypopituitarism) / Q87.8 (Other specified congenital malformation syndromes) |
| LOINC Code | 81265-2 (Gene mutation panel) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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