Test Price
2,800 AEDโ Home Collection Available
NDUFAF5 Gene Mitochondrial Complex I Deficiency Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
ISO 9001:2015 accredited laboratory in Dubai delivers definitive NDUFAF5 gene sequencing with 99.9% diagnostic sensitivity for mitochondrial complex I deficiency. Services include ISO-certified cold-chain home collection (8 AMโ11 PM) and VIP mobile phlebotomy. Direct insurance billing verification via WhatsApp +971 54 548 8731. Post-test telephonic clinical guidance by a DHA-licensed Consultant Medical Genetics specialist.
- Price: 2,800 AED โ all-inclusive with mandatory pre-test genetic counselling
- Turnaround Time: 3โ4 weeks from sample receipt
- Methodology: Full NDUFAF5 gene sequencing via Illumina NovaSeq NGS platform with CNV analysis
- Sample Types Accepted: Peripheral whole blood, extracted DNA, or dried blood spot (FTA card)
Test Overview & Methodology
The NDUFAF5 gene test utilizes advanced Next Generation Sequencing (NGS) to identify pathogenic variants responsible for mitochondrial complex I deficiency โ a severe, often progressive neurological disorder. This nuclear-encoded gene defect underlies conditions such as Leigh syndrome, progressive encephalopathy, and cardiomyopathy. Results empower neurologists, medical geneticists, and genetic counselors to establish a molecular diagnosis, guide precision treatment, and inform family planning decisions.
Test Comparison: NDUFAF5 Gene Sequencing vs. Whole Mitochondrial DNA Sequencing
| Feature | Our NDUFAF5 Test | Whole Mitochondrial DNA Sequencing |
|---|---|---|
| Precision | >99% sensitivity/specificity via Illumina NovaSeq NGS platform | May miss nuclear gene mutations; targeted only to mtDNA |
| Methodology | Full gene sequencing with copy number variant analysis; LC-MS/MS validation if needed | Sanger sequencing or qPCR arrays |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Diagnostic Range | NDUFAF5 nuclear gene โ definitive for complex I deficiency | Entire mitochondrial genome; cannot detect nuclear-encoded mitochondrial disorders |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist with extensive experience in mitochondrial disorders, I emphasize that NDUFAF5 gene sequencing is essential for confirming complex I deficiency in patients presenting with Leigh syndrome, progressive encephalopathy, or unexplained cardiomyopathy. Results must always be correlated with a detailed neurological examination, metabolic workup, and a three-generation family pedigree. A negative result does not exclude all mitochondrial pathology; multidisciplinary follow-up remains mandatory."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice: Medication & Supplement Continuity
โ ๏ธ Important Clinical Advisory
Do not discontinue any prescribed medication, vitamin, or cofactor supplement (e.g., thiamine, riboflavin, coenzyme Q10) without prior consultation with your treating neurologist or metabolic specialist. This genetic test does not replace urgent medical evaluation in an emergency setting.
Exclusion Criteria & Emergency Red Flags
Contraindications for Home Collection
- Exclusion: Active febrile illness or unmanaged bleeding diathesis at time of home collection; inability to provide informed consent (mandatory pre-test genetic counselling must be completed); minors without legal guardian consent as per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Exclusion: Hemolysed, clotted, or improperly preserved samples (temperature-controlled cold-chain must be maintained throughout transit).
Emergency Red Flags
If the patient experiences acute onset of seizures, respiratory distress, severe hypotonia, lactic acidosis, or loss of consciousness while awaiting results, proceed immediately to the nearest emergency department. This test is not a substitute for acute medical care.
Patient FAQ & Clinical Guidance
1. What exactly does the NDUFAF5 genetic test detect, and why is it ordered?
This test detects pathogenic DNA variants in the NDUFAF5 gene that cause mitochondrial complex I deficiency, providing a molecular diagnosis for conditions such as Leigh syndrome, progressive encephalopathy, and cardiomyopathy. Neurologists and medical geneticists order it to confirm a clinical suspicion and guide precision treatment, including cofactor supplementation and metabolic management.
2. How is the sample collected, and what preparations are required before the test?
A certified phlebotomist performs a simple, painless home blood draw โ or you may provide a dried blood spot (FTA card) sample. A mandatory pre-test genetic counselling session is required to discuss implications, review the three-generation family pedigree, and obtain written informed consent in accordance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability. No special dietary preparation is needed.
3. How long until I receive my results, and does insurance cover the cost?
Turnaround time is 3โ4 weeks from sample receipt at our Dubai laboratory. We handle direct insurance billing verification โ simply send your policy details via WhatsApp to +971 54 548 8731, and our team confirms coverage before sample collection. The all-inclusive price is 2,800 AED, which covers the full gene sequencing analysis, CNV detection, and the mandatory genetic counselling session.
UAE Regulatory & Data Privacy Adherence
This diagnostic service complies fully with UAE federal data protection and health informatics regulations. All patient genetic data is processed and stored in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and informed consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is an ISO 9001:2015 accredited facility licensed by the Dubai Health Authority (DHA License 1143).
Clinical & Logistical Metadata
| Test Name | NDUFAF5 Gene Mitochondrial Complex I Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or dried blood spot (FTA card) |
| Methodology Used | Next Generation Sequencing (Illumina NovaSeq) with CNV analysis; LC-MS/MS validation if required |
| ICD-10-CM Code | E88.49 (Other mitochondrial metabolism disorders), G31.89 (Other specified degenerative diseases of nervous system) |
| LOINC Code | 51966-7 (Genetic analysis of specified gene in Blood by Sequencing) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
ุฏุนู ุซูุงุฆู ุงููุบุฉ ู ุชุงุญ
ุงูุชุญูู ู ู ุงูุชุบุทูุฉ ุงูุชุฃู ูููุฉ
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
ุชููู ุนู ุงูุชุฎู ูู. ุฃุฑุณู ุตูุฑุฉ ู ู ุจุทุงูุฉ ุงูุชุฃู ูู ููุตูุฉ ุงูุทุจูุจ ุฅูู ูุฑูู ุงูุชุญูู ุงูู ุนุชู ุฏ ู ู ููุฆุฉ ุงูุตุญุฉ ุจุฏุจู ุนุจุฑ ุงููุงุชุณุงุจ. ุงุญุตู ุนูู ุชุญุฏูุซ ุงูุญุงูุฉ ูู ุฏูุงุฆู.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians