Test Price
2,800 AED✅ Home Collection Available
MRAP Gene Glucocorticoid Deficiency Type 2 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
This MRAP Gene NGS Test provides definitive genetic diagnosis for Familial Glucocorticoid Deficiency Type 2 with 99.9% diagnostic sensitivity, performed under ISO 9001:2015 accredited protocols. The service includes hospital‑grade home collection, 3–4 week turnaround, post‑test clinical guidance, and direct insurance verification.
Test Overview & Methodology
This Genetic Test comprehensively analyzes the MRAP gene to diagnose Familial Glucocorticoid Deficiency Type 2 (FGD2), a rare autosomal recessive disorder causing life‑threatening adrenal crisis due to isolated cortisol deficiency. Results guide urgent endocrine management, family screening, and reproductive planning.
Next‑Generation Sequencing (NGS) on the Illumina® platform provides full gene coverage with 99.9% sensitivity. The test identifies pathogenic single‑nucleotide variants, small insertions/deletions, and splice‑site alterations across all coding exons and flanking intronic regions.
| Feature | Our Test (MRAP NGS) | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity, full gene sequencing | Targeted mutation panel, lower sensitivity |
| Method | NGS (Illumina® platform), ISO 9001:2015 | PCR‑based, limited to known variants |
| Turnaround | 3–4 Weeks | 3–5 Weeks |
| Regulatory | DHA‑licensed, UAE PDPL compliant | May lack regional accreditation |
Physician Insight & Safety Protocols
“A positive MRAP result is a life‑changing diagnosis, but it is the first step toward protecting your child. I emphasize that genetic findings must be interpreted alongside clinical symptoms and endocrinological evaluation—never in isolation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Safety Advisory
⚠ Medication Warning
Do not discontinue prescribed glucocorticoid replacement therapy without consulting your doctor. Abrupt cessation in affected individuals can precipitate acute adrenal crisis, a medical emergency requiring immediate hospitalisation.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria & Red Flags
- Exclusion: Patients unwilling or unable to provide informed consent (mandatory genetic counselling required).
- Exclusion: Individuals with bleeding disorders unsuitable for phlebotomy; alternative dry blood spot collection may be evaluated.
- ER Red Flag: If the patient develops sudden severe weakness, vomiting, hypotension, or altered consciousness, seek emergency care immediately and mention possible adrenal insufficiency.
- ER Red Flag: For infants: poor feeding, lethargy, and hypoglycaemia are critical alert signs requiring urgent medical attention.
Patient FAQ & Clinical Guidance
1. What does the MRAP genetic test diagnose and when is it needed?
Snippet: MRAP gene sequencing identifies pathogenic variants causing familial glucocorticoid deficiency type 2 for definitive genetic diagnosis, carrier detection, and prenatal counselling.
It is indicated in infants or children with unexplained hypoglycaemia, hyperpigmentation, and recurrent infections, especially when morning cortisol and ACTH levels suggest isolated glucocorticoid deficiency. The test clarifies the genetic aetiology, distinguishes from other adrenal insufficiencies, and informs life‑long cortisol replacement.
2. How is the sample collected and what is the expected turnaround time?
Snippet: Sample collection requires a blood draw or one‑drop blood on FTA card, processed via NGS with a 3–4 week turnaround time.
Our certified phlebotomist performs VIP mobile phlebotomy at home with temperature‑controlled cold‑chain logistics, or you can submit extracted DNA. The dry blood spot option is ideal for neonates. After the laboratory receives the sample, NGS analysis and bio‑informatic interpretation take 3 to 4 weeks, with direct report delivery to your physician.
3. What does a positive result mean and what are the next steps?
Snippet: A positive MRAP mutation result confirms familial glucocorticoid deficiency type 2, requiring immediate endocrinology consultation and lifelong cortisol replacement therapy.
A positive outcome identifies two pathogenic variants (homozygous or compound heterozygous), establishing the diagnosis. The patient must be referred to a paediatric endocrinologist for glucocorticoid therapy initiation; family cascade testing is recommended. Negative results may still require further evaluation if clinical suspicion remains high.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security Framework: This service fully complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for diagnostic purposes with explicit patient consent.
Clinical Safety & Consent: Patient safety and informed consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring that every test is ordered by a licensed physician and accompanied by mandatory genetic counselling.
Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). All assays are processed in DHA‑licensed laboratories under the supervision of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | MRAP Gene NGS Sequencing – Familial Glucocorticoid Deficiency Type 2 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Dried Blood Spot (FTA Card). VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next‑Generation Sequencing (NGS) on Illumina® platform, ISO 9001:2015 accredited |
| ICD-10-CM Code | E27.4 (Adrenocortical insufficiency, unspecified) |
| LOINC Code | 94122-3 (MRAP gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Address | DNA Labs UAE – DHA Facility License No. 1143. Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. |
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All reports reviewed by DHA-Certified physicians