Test Price
2,800 AED✅ Home Collection Available
MPDZ Gene Hydrocephalus, Nonsyndromic, Autosomal Recessive Type 2 Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing with Sanger confirmation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post-test clinical guidance by a DHA-licensed Consultant Medical Genetics.
- Insurance: Direct Billing Verification — send your insurance card via WhatsApp +971 54 548 8731.
- Pricing: 2,800 AED inclusive of comprehensive clinical report and bioinformatics analysis.
Test Overview & Methodology
The MPDZ gene test utilizes next-generation sequencing (NGS) to analyze the entire coding region and splice sites of the MPDZ gene. Pathogenic biallelic variants cause autosomal recessive nonsyndromic hydrocephalus type 2. This molecular diagnosis is essential for neurosurgical planning, prognosis, and recurrence risk assessment for families. The test is performed on genomic DNA extracted from a peripheral whole blood sample or buccal swab, with Sanger confirmation of all clinically significant variants.
| Feature | Our Test (NGS with Sanger) | Closest Alternative (Targeted PCR Panel) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity for MPDZ variants | Limited to pre-defined hotspots; may miss rare mutations |
| Methodology | Next-Generation Sequencing (NGS) with full bioinformatics confirmation | Sanger sequencing of select exons only |
| Turnaround | 3–4 weeks with comprehensive clinical report | 4–6 weeks, often requiring additional reflex testing |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I have seen how definitive molecular diagnosis can transform care for families affected by hydrocephalus. The MPDZ gene analysis provides clarity for surgical decision-making and enables accurate recurrence risk counseling. However, results must always be interpreted in the context of clinical findings, neuroimaging, and developmental history. Genetic counseling is an integral part of the testing process.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication and Clinical Advisory
Do not discontinue prescribed medications or delay surgical interventions without consulting your physician. This genetic test is not a substitute for clinical evaluation or emergency care.
Exclusion Criteria & ER Red Flags
- Not suitable for individuals who have not undergone pre-test genetic counselling or lack informed consent.
- Avoid sample collection during acute febrile illness or untreated coagulation disorders.
- If you experience sudden severe headache, projectile vomiting, vision loss, or altered consciousness, seek emergency care immediately — these may indicate acute hydrocephalus exacerbation unrelated to genetic results.
Patient FAQ & Clinical Guidance
1. What clinical purpose does the MPDZ gene test serve?
The test identifies biallelic pathogenic variants in MPDZ to confirm nonsyndromic autosomal recessive hydrocephalus type 2, guiding neurosurgical decisions and family planning.
2. How is the sample collected and what type of specimen is required?
A peripheral whole blood sample or buccal swab is collected by our VIP mobile phlebotomy team. The sample is then processed using next-generation sequencing with Sanger confirmation.
3. What does a positive MPDZ test result mean for the patient and family?
A positive result confirms biallelic pathogenic variants, establishing a diagnosis of autosomal recessive hydrocephalus type 2. This allows for precise recurrence risk assessment for future pregnancies and informs surgical planning.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance
This genetic service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent are in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. All testing is processed under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) with secure, encrypted reporting.
Clinical & Logistical Metadata
| Test Name | MPDZ Gene Sequencing (Hydrocephalus, Nonsyndromic, Autosomal Recessive Type 2) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks (21–28 business days) |
| Sample Type / Matrix | Whole Blood or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q03.9 |
| LOINC Code | 96567-0 |
| DHA Facility License & Laboratory Address | License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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