Test Price
2,800 AED✅ Home Collection Available
MARS2 Gene Spastic Ataxia Type 3 (Autosomal Recessive) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
DHA-Approved Clinicتحليل جين MARS2 للرنح التشنجي النوع 3 (صبغي جسدي متنحي) بتقنية التسلسل الجيني المتقدم NGS في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary
- Diagnostic Precision: 99.9% analytical sensitivity via ISO 9001:2015 accredited NGS platform.
- Premium Logistics: VIP Hospital-Grade Home Collection (8 AM – 11 PM daily) with certified cold-chain transport and licensed phlebotomists.
- Clinical Support: Complimentary post-test teleconsultation for interpretation with a DHA-licensed neurologist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview
The MARS2 gene test employs next-generation sequencing to detect pathogenic variants responsible for autosomal recessive spastic ataxia type 3, a progressive neurodegenerative disorder marked by spasticity and cerebellar dysfunction. (يكشف هذا الفحص عن طفرات جين MARS2 المسببة للرنح التشنجي الوراثي النوع الثالث.)
| Feature | Our MARS2 NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Methodology | Targeted NGS with deep (>100×) coverage of the entire MARS2 gene, including intron–exon boundaries | Whole exome capture; may miss deep intronic or regulatory variants; requires reflex to Sanger confirmation |
| Diagnostic Sensitivity | >99.9% for known pathogenic variants in MARS2 | ~98% depending on capture kit; often lower coverage for specific ataxia genes |
| Turnaround Time | 3–4 weeks | 5–7 weeks (plus bioinformatics analysis) |
| Price | 2800 AED | approx. 3500–4500 AED |
| Pre-test Counseling | Included genetic counseling session with pedigree chart | Often not included; may require separate appointment |
Clinical Perspective from Dr. PRABHAKAR REDDY (DHA License: 61713011)
"This genetic test provides crucial molecular confirmation, but results must always be interpreted within the context of the patient’s full neurological examination and family history. A positive result can guide management and genetic counselling, while a negative result may warrant further investigation for phenocopies. Please remember that no single test replaces the judgment of your treating physician."
⚠️ Medication Warning: Do not discontinue any prescribed medication without consulting your doctor. Genetic results do not alter emergency or ongoing symptomatic treatment.
Safety Exclusion Criteria & Red Flags
- Exclusion Criteria: Recent allogeneic blood transfusion (< 4 weeks); known severe coagulopathy (unless sample collected by specialist); inability to provide informed consent.
- Emergency Red Flags: Seek immediate medical attention if you experience sudden loss of balance, acute vision loss, first-time seizures, or rapid worsening of spasticity with respiratory difficulty.
- All home collections are performed by DHA-licensed phlebotomists under strict aseptic protocols.
Regulatory Compliance & Data Privacy
- DHA Facility License: 9834453
- ISO 9001:2015 Certification: Certificate No. INT/EGQ/2509DA/3139
- Federal Decree-Law No. 41 of 2024 (Art. 87): All medical claims are strictly factual, avoiding any misleading promotion.
- CDS Law 2026 (Minors): Parental consent is mandatory; paediatric genetic testing follows UAE child protection guidelines.
- UAE PDPL (Federal Decree-Law No. 45 of 2021): Genetic data is encrypted end‑to‑end and never shared without explicit consent.
- Pre-test genetic counseling and pedigree charting are integral to the service, aligning with DHA clinical governance.
Patient FAQ & Clinical Guidance
Q1: What is the MARS2 gene and what does this test detect?
Next-generation sequencing of the MARS2 gene detects mutations causing autosomal recessive spastic ataxia type 3. This comprehensive analysis reads the entire coding region to identify point mutations, small insertions/deletions, and copy number variants associated with the phenotype.
س1: ما هو اختبار جين MARS2 وماذا يكشف؟
يقوم هذا الفحص بتسلسل جين MARS2 بالكامل للكشف عن الطفرات المسببة للرنح التشنجي الصبغي الجسدي المتنحي النوع الثالث.
Q2: Who should consider this?
Those with progressive gait disturbance, spasticity, family history of ataxia should consider MARS2 gene testing. Clinically indicated for individuals presenting with early‑onset spastic paraparesis, dysarthria, and cerebellar atrophy on MRI, especially in consanguineous families.
س2: من هم المرشحون لإجراء هذا الفحص؟
الأشخاص الذين يعانون من اضطراب تدريجي في المشي، والتشنج، وتاريخ عائلي للرنح ينبغي لهم النظر في فحص جين MARS2.
Q3: What sample is required and how is collection performed?
A simple blood draw or FTA card is collected by licensed phlebotomists at your home. Options include whole blood (EDTA tube), extracted DNA, or a single drop on an FTA card. All samples are transported in temperature‑controlled containers.
س3: ما هي العينة المطلوبة وكيف يتم جمعها؟
يتم جمع عينة دم بسيطة أو بطاقة FTA بواسطة فني سحب دم مرخص في منزلك.
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