Test Price
2,800 AEDโ Home Collection Available
LHB Gene Hypogonadotropic Hypogonadism Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary
This advanced genetic assay provides comprehensive analysis of the LHB gene associated with hypogonadotropic hypogonadism using internationally validated Next-Generation Sequencing (NGS) technology compliant with ISO 9001:2015 standards. The test delivers 99.9% diagnostic sensitivity with integrated pre- and post-test genetic counseling, state-approved mobile phlebotomy services across the UAE, and precise clinical interpretation by DHA-licensed physicians. Price: 2800 AED. Turnaround time: 3 to 4 weeks.
- โ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- โ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM โ 11 PM, UAE-wide).
- โ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation provided by DHA-licensed physicians.
- โ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The LHB Gene Hypogonadotropic Hypogonadism Genetic Test is a high-precision molecular diagnostic assay designed to detect pathogenic variants in the luteinizing hormone beta subunit (LHB) gene, which is directly implicated in idiopathic hypogonadotropic hypogonadism (IHH). This test utilizes Next-Generation Sequencing (NGS) technology to deliver comprehensive coverage of coding exons, splice-site junctions, and regulatory regions.
| Feature | Our Test (Premium NGS Panel) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) โ Full Gene Coverage | Sanger Sequencing โ Targeted Exon-Only |
| Diagnostic Sensitivity | 99.9% | ~95% (Limited to Known Hotspots) |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Copy Number Variant (CNV) Detection | Included | Not Available |
| Bioinformatics Pipeline | AI-Enhanced, ACMG Guidelines | Manual Interpretation |
| Price | 2800 AED | 1800โ2500 AED (Variable) |
Accepted Sample Types
All samples are transported via ISO-certified cold-chain logistics. FTA cards offer convenient ambient-temperature shipping for remote collection locations.
Physician Insight & Safety Protocols
Clinical Note from Ms. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403):
"As a clinical geneticist, I underscore that LHB gene testing provides critical molecular insight into the etiology of hypogonadotropic hypogonadism; however, all results must be interpreted alongside thorough endocrinological assessment including serum LH, FSH, and testosterone levels. A pathogenic variant confirms genetic predisposition but does not supplant the necessity of longitudinal clinical monitoring. I strongly recommend that every patient undergo pre-test and post-test genetic counseling to fully comprehend the implications for family planning and long-term health surveillance."
Advisory & Pre-Test Requirements
โ Medication Advisory
Do not discontinue any prescribed medication, including hormone replacement therapy (testosterone, gonadotropins), without consulting your treating physician. Abrupt cessation of endocrine medications may lead to serious adverse effects including acute adrenal insufficiency, severe mood disturbances, and metabolic decompensation.
Pre-Test Requirements
- A comprehensive clinical history documenting pubertal development, reproductive history, and endocrine evaluation must be provided.
- A formal genetic counseling session is mandatory to draw a detailed pedigree chart identifying all family members affected by hypogonadotropic hypogonadism or LHB gene-related conditions.
- Drug & Supplement Avoidance Prior to Blood Draw: Avoid biotin (Vitamin B7) supplementation for at least 72 hours before collection, as it may interfere with certain laboratory assays. Disclose all androgenic compounds, anabolic steroids, and hormonal supplements to the ordering physician.
- Fasting is not required unless concurrent biochemical testing (e.g., glucose, lipid profile) is ordered.
- Valid Emirates ID or passport must be presented at the time of sample collection.
Exclusion Criteria & Emergency Red Flags
โ Exclusion Criteria (Do NOT proceed with sample collection if any apply):
- Active febrile illness (temperature > 38.5ยฐC) or systemic infection requiring hospitalization.
- Inability to provide valid informed consent due to cognitive impairment, acute psychiatric decompensation, or altered mental status.
- Minors under 18 years of age without documented parental or legal guardian consent, in strict compliance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Known bleeding diathesis or severe thrombocytopenia (platelet count < 50,000/ยตL) if venipuncture is the collection method.
- Current pregnancy in the third trimester with obstetric complications (requires specialist clearance).
Emergency Red Flags โ Seek Immediate Medical Attention:
- Sudden onset of severe headache, visual field defects, or symptoms suggestive of pituitary apoplexy.
- Acute adrenal crisis symptoms: profound weakness, hypotension, severe abdominal pain, vomiting, and confusion.
- Suicidal ideation or severe psychological distress following disclosure of genetic test results โ contact emergency services or the UAE National Helpline immediately.
- Syncope, anaphylaxis, or any severe adverse reaction during or after the blood collection procedure.
Primary Specialist Referral Network
Specialist in reproductive endocrinology and hypogonadism management. Oversees hormone replacement protocols and clinical correlation of genetic findings.
Provides pre-test counseling, pedigree analysis, variant interpretation per ACMG guidelines, and family risk assessment for LHB-associated disorders.
Serves as the primary point of initial clinical suspicion, coordinates referrals, and integrates genetic test results into the broader health management plan.
Patient FAQ & Clinical Guidance
1. What does the LHB gene test actually detect, and who should consider taking it?
This NGS-based genetic test detects pathogenic mutations in the LHB gene that cause hypogonadotropic hypogonadism, a condition where the pituitary gland fails to produce adequate luteinizing hormone, leading to impaired pubertal development and infertility. The test is clinically indicated for individuals presenting with delayed or absent puberty, low serum LH and testosterone levels with normal pituitary imaging, idiopathic infertility, and for family members of a confirmed LHB mutation carrier seeking cascade screening.
2. How should I prepare for the blood collection, and what is the process for home collection in the UAE?
Preparation involves discontinuing biotin supplements 72 hours prior, disclosing all medications to the ordering physician, and attending a mandatory pre-test genetic counseling session where a detailed three-generation pedigree chart is documented. Our UAE-wide VIP mobile phlebotomy service operates daily from 8 AM to 11 PM, dispatching a DHA-licensed phlebotomist to your home or office with full cold-chain transport capability; simply schedule via WhatsApp at +971 54 548 8731, and the sample is processed at our ISO 9001:2015-certified laboratory with results delivered within 3 to 4 weeks.
3. What happens after I receive my results, and is my genetic data protected under UAE law?
Upon receiving your results, a complimentary telephonic post-test clinical guidance session with a DHA-licensed physician is provided to explain the findings, discuss clinical implications, and outline any necessary follow-up with an endocrinologist or clinical geneticist. Your genetic data is fully protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, mandating that all genomic information is stored on encrypted, air-gapped servers with access restricted to authorized laboratory personnel only; data is never shared with third parties without explicit written consent.
4. How long does it take to get results, and what is included in the final report?
The standard turnaround time is 3 to 4 weeks from sample receipt at the laboratory. The final clinical report includes a detailed interpretation of all identified variants classified according to ACMG guidelines, relevant gene coverage metrics, clinical recommendations, and a clear statement of pathogenicity. A copy is securely delivered via encrypted email or the patient portal, and a telephonic review is scheduled with a genetics specialist.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection Framework
- Federal Decree-Law No. 45 of 2021 (PDPL): All patient health information, including genetic data, is processed, stored, and transmitted under strict encryption protocols with access limited to authorized personnel.
- Federal Law No. 2 of 2019: This laboratory operates in full compliance with the UAE law concerning the use of information and communication technology in health fields, ensuring secure handling of all electronic medical records and genomic data.
- Federal Decree-Law No. 4 of 2016: Clinical testing safety and patient consent procedures strictly adhere to this law on medical liability, guaranteeing informed consent and ethical clinical practice.
- ISO 9001:2015 Certification: Cert: INT/EGQ/2509DA/3139 โ ensuring quality management systems meet international standards for diagnostic accuracy.
- DHA Facility License: 1143 โ Licensed and audited by the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | LHB Gene Hypogonadotropic Hypogonadism Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA Tube), Extracted DNA (Minimum 1 ยตg), One Drop Blood on FTA Card, DNA FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage including coding exons, splice-site junctions, and regulatory regions |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 21656-9 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
Schedule Your LHB Gene Test Today
Home Collection Available UAE-Wide | 8 AM โ 11 PM | ISO Certified Cold-Chain Logistics
+971 54 548 8731
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All reports reviewed by DHA-Certified physicians