Test Price
2,800 AED✅ Home Collection Available
LBR Gene Pelger-Huët Anomaly Next-Generation Sequencing (Genetic Test in UAE | 2800 AED)
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM across all UAE emirates.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed Medical Genetics Consultant.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LBR Gene Pelger-Huët Anomaly Genetic Test is a comprehensive next-generation sequencing assay that analyzes the entire coding region of the LBR gene to detect heterozygous or homozygous variants associated with Pelger-Huët anomaly and related dysmorphology syndromes. The test provides high-resolution detection of single nucleotide variants, small insertions/deletions, and copy number variations across the entire gene.
| Feature | Our Test (ISO-Accredited) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Analytical Sensitivity via Illumina NovaSeq & clinical-grade bioinformatics | Sanger sequencing of limited regions; may miss deep intronic mutations |
| Methodology | NGS (Next-Generation Sequencing) – full gene coverage with CNV detection | Capillary sequencing; lower throughput |
| Turnaround Time | 3 to 4 Weeks (DHA-compliant) | 5–8 weeks typical |
Pediatricians
Evaluating children with unexplained dysmorphism, recurrent infections, or suspected hereditary neutropenia; Pelger-Huët anomaly screening guides early intervention and genetic counseling.
Neonatologists
Confirming suspected Pelger-Huët anomaly in newborns with abnormal neutrophil morphology on peripheral smear, helping differentiate from transient neonatal conditions.
Clinical Geneticists
Establishing molecular diagnosis for family planning, cascade testing, and precise genotype-phenotype correlation in dysmorphology syndromes linked to LBR mutations.
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“This test detects pathogenic LBR gene variants responsible for Pelger-Huët anomaly, a predominantly benign condition characterized by hyposegmented neutrophil nuclei. A positive result confirms the hereditary form but rarely impacts immune function. It is imperative to correlate genetic findings with complete blood count morphology and family history. Genetic counseling is recommended to explain autosomal dominant inheritance and to address any concerns regarding offspring risk. Patients should not alter any prescribed medication based solely on this test without consulting their managing physician.”
Medication Advisory
⚠️ Do not discontinue any prescribed medication or supplement based solely on genetic test results. Always consult your treating doctor before making changes to your medical regimen.
Safety Exclusion Criteria & Red Flags
- Exclusion: Individuals with active febrile illness or uncontrolled infection should postpone sample collection to avoid confounding blood parameters.
- Exclusion: Patients on high-dose steroid therapy may exhibit altered leukocyte morphology; clinical history must be provided for accurate interpretation.
- ER Red Flags: If your child develops sudden pallor, petechiae, or signs of sepsis, seek immediate emergency care – do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What is the LBR gene test and how does it diagnose Pelger-Huët anomaly?
This NGS-based test analyzes the entire LBR gene coding region for pathogenic variants that cause the characteristic hyposegmentation of neutrophil nuclei seen in Pelger-Huët anomaly. A positive result confirms hereditary Pelger-Huët anomaly, which is typically a benign condition with normal immune function, requiring no treatment beyond genetic counseling.
2. What sample types are accepted and is home collection available?
We accept whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card. Our ISO-certified VIP mobile phlebotomy team provides temperature-controlled cold-chain home collection across all UAE emirates, including Dubai, Abu Dhabi, and Sharjah, ensuring sample stability and convenience.
3. What is the turnaround time and how will I receive my results?
Results are typically available within 3 to 4 weeks and are delivered via a secure, encrypted online portal. Optional telephonic clinical guidance is provided by a DHA-licensed genetic counselor. Direct billing to major insurers can be verified prior to sample collection.
UAE Regulatory & Data Privacy Adherence
Our laboratory operates under the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and complies with Federal Law No. 2 of 2019 concerning the use of information and communication technology in health fields. All genetic data is encrypted, access-controlled, and handled with strict confidentiality. For minors, parental consent is mandatory in accordance with UAE regulatory standards. The DHA Facility License Number is 1143.
Clinical & Logistical Metadata
| Test Name | LBR Gene Pelger-Huët Anomaly Next-Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card (dried blood spot) |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage and CNV detection |
| ICD-10-CM Code | D72.0 |
| LOINC Code | 34179-6 |
| DHA Facility License & Laboratory Address | DNA Labs UAE – DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians