Test Price
2,800 AED✅ Home Collection Available
LAMA5 Gene Sequencing (Focal Segmental Glomerulosclerosis, LAMA5‑Related) Genetic Test in UAE
Executive Summary & Core Metrics
The LAMA5 Gene Sequencing Test is a specialized next-generation sequencing (NGS) analysis designed to detect pathogenic variants in the LAMA5 gene associated with hereditary focal segmental glomerulosclerosis (FSGS) and related multi-system disorders.
- Accuracy Guarantee: 99.9% Analytical Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Temperature-Controlled Cold-Chain Home Collection; VIP Mobile Phlebotomy available 8 AM – 11 PM.
- Clinical Guidance: Complimentary post-test telephonic result interpretation by a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LAMA5 Genetic Test utilizes Next-Generation Sequencing (NGS) to analyze the complete coding sequence of the laminin alpha-5 (LAMA5) gene. Pathogenic variants in LAMA5 can disrupt the glomerular basement membrane, leading to proteinuria and progressive kidney damage. This test provides a definitive molecular diagnosis for hereditary FSGS, distinguishing it from secondary causes of nephrotic syndrome.
| Feature | Our LAMA5 NGS Test | Closest Alternative (Whole-Exome Screening) |
|---|---|---|
| Precision | 99.9% sensitivity for LAMA5 coding regions | ~95% due to incidental findings and variable coverage |
| Methodology | Targeted Next-Generation Sequencing (NGS) with full gene coverage | Exome-wide capture; lower depth of coverage for single gene analysis |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Cost Efficiency | Targeted analysis reduces cost and incidental findings | Higher cost due to broader sequencing scope |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I emphasize that a positive LAMA5 result confirms a hereditary predisposition to FSGS. However, this molecular finding must be carefully integrated with renal biopsy histology, detailed family pedigree analysis, and the complete clinical presentation. Genetic counseling is strongly recommended for all patients and their families before and after testing. This test is a powerful diagnostic tool, not a standalone decision-making device.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
⚠ Medication Warning
Do not discontinue, alter, or adjust prescribed medications, especially immunosuppressants, corticosteroids, or anti-hypertensives, without explicit consultation with your treating nephrologist or primary care physician.
Exclusion Criteria & Emergency Red Flags
Contraindications for Sample Collection
- Active febrile illness or systemic infection – postpone collection until resolved.
- Age less than 1 year: mandatory genetic counseling consultation required before sampling.
- Urgent nephrology referral is required if sudden oliguria, severe edema, or hypertensive crisis develops prior to or during the testing window.
Patient FAQ & Clinical Guidance
1. What does the LAMA5 NGS test actually detect?
This test reads the entire coding sequence of the LAMA5 gene to identify pathogenic mutations causing focal segmental glomerulosclerosis (FSGS). Pathogenic variants in the laminin alpha-5 chain disrupt the glomerular basement membrane, leading to proteinuria and progressive kidney damage. The result provides a definitive molecular diagnosis for hereditary FSGS.
2. How long does it take to receive my LAMA5 DNA results in the UAE?
Your LAMA5 NGS genetic report is delivered within 3 to 4 weeks from sample arrival at our ISO-accredited laboratory. The 21-to-28-day turnaround includes rigorous sequencing, advanced bioinformatic analysis, and dual clinical interpretation by a Consultant Medical Geneticist.
3. Is home sample collection available and safe for genetic tests in Dubai?
Yes, we offer DHA-compliant, temperature-controlled cold-chain home collection by certified phlebotomists from 8 AM to 11 PM across all UAE emirates. Your blood or FTA card sample is transported in a controlled environment to preserve DNA integrity for accurate sequencing.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed under the regulatory framework of the Dubai Health Authority (DHA) and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols strictly follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic data is handled with the highest level of confidentiality and security.
Clinical & Logistical Metadata
| Test Name | LAMA5 Gene Sequencing (Focal Segmental Glomerulosclerosis, LAMA5-Related) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card Sample |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | N04.1 |
| LOINC Code | 81263-5 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians