Test Price
2,800 AEDโ Home Collection Available
KRAS Gene Sequencing for Cardiofaciocutaneous Syndrome โ Genetic Diagnostic Test in Dubai, UAE
Executive Summary & Core Metrics
Core Metrics & Executive Summary
The KRAS Gene Sequencing for Cardiofaciocutaneous Syndrome employs next-generation sequencing (NGS) to detect pathogenic variants in the KRAS gene with a diagnostic sensitivity exceeding 99.9%. Our service includes VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM, followed by a telephonic genetic counseling session upon result issuance. Direct insurance coverage confirmation via WhatsApp is available at +971 54 548 8731.
Test Overview & Methodology
The KRAS Gene Cardiofaciocutaneous Syndrome Genetic Test identifies pathogenic variants in the KRAS gene associated with this rare multisystem disorder, which primarily affects the heart, skin, and craniofacial development. This next-generation sequencing approach offers comprehensive coverage of the coding region and splice sites, delivering a 99.9% diagnostic sensitivity when performed in our DHA-licensed UAE facility.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Targeted Mutation Analysis) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) โ full coding region | Sanger sequencing of selected exons only |
| Diagnostic Sensitivity | 99.9% | ~70โ80% (misses novel/rare variants) |
| Turnaround Time | 3โ4 Weeks | 2โ3 Weeks |
| Regulatory Compliance | DHA Licensed, ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Often lacks local DHA accreditation |
| Post-Test Support | Included telephonic genetic counselling | May require separate consult |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I have seen firsthand how a definitive molecular diagnosis for Cardiofaciocutaneous syndrome can transform a family's journey from uncertainty to empowered care planning. However, it is critical that any genetic result is interpreted within the full clinical context, including echocardiographic findings and dermatologic evaluation. This NGS test is highly accurate, but it must never replace ongoing specialist follow-up for the cardiac and cutaneous manifestations that define this condition. Always involve your treating physician before making any therapeutic decisions based on genetic findings."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Medication Advisory
Do not discontinue prescribed medication without consulting your doctor.
Safety Exclusion Criteria & Red Flags
- Active febrile illness or acute infection โ blood collection should be deferred until recovery.
- Known bleeding disorders or anticoagulant therapy โ notify the phlebotomist before venipuncture.
- Pregnancy is not a contraindication, but always inform your healthcare provider.
- Emergency Red Flags: If you experience sudden chest pain, severe shortness of breath, cyanosis (bluish skin), or altered consciousness, seek immediate emergency careโdo not wait for a genetic test result.
Patient FAQ & Clinical Guidance
1. What is the KRAS gene test for Cardiofaciocutaneous syndrome, and who should consider it?
This NGS test detects KRAS mutations causing Cardiofaciocutaneous syndrome, a rare disorder affecting heart, skin, and facial development. It is recommended for individuals with a family history or symptoms such as congenital heart defects, developmental delay, and characteristic skin rash. The test should be performed after consultation with a cardiologist or clinical geneticist.
2. How is the test performed, and is home collection available in the UAE?
A certified phlebotomist collects a peripheral whole blood sample (or extracted DNA with prior approval) via a VIP home visit using temperature-controlled cold-chain logistics to ensure sample stability. The service is available daily from 8 AM to 11 PM. The final report is issued within 3โ4 weeks, followed by a telephonic genetic counseling session.
3. What do the results mean, and will I receive medical guidance after the test?
A positive result confirms a pathogenic variant in the KRAS gene, enabling targeted management and specialist follow-up for cardiac and skin manifestations. A negative result rules out the syndrome in most cases. The service includes a post-result telephonic consultation with a genetic counselor to explain the clinical implications accurately.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled with the highest confidentiality, encrypted during transmission and storage, and access is limited to authorized personnel only. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility holds DHA Laboratory License No. 1143 and operates under the corporate branding of DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | KRAS Gene Sequencing for Cardiofaciocutaneous Syndrome (Genetic Test) |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Extracted DNA (saliva acceptable with prior approval) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Sequencing |
| ICD-10-CM Code | Q87.89 (Other specified congenital malformation syndromes) |
| LOINC Code | 98734-8 (KRAS gene full sequencing) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians