Test Price
2,800 AED✅ Home Collection Available
ITK Gene Lymphoproliferative Syndrome Type 1 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ITK لمتلازمة التكاثر اللمفاوي من النوع الأول في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Clinical Summary
This definitive Next‑Generation Sequencing (NGS) test analyzes the entire coding region of the ITK gene to detect pathogenic variants responsible for Lymphoproliferative Syndrome Type 1 (LPFS1). يُقدم هذا الفحص الجيني الشامل تحليلًا دقيقًا للطفرات المسببة لمتلازمة التكاثر اللمفاوي من النوع الأول، مما يوفر تشخيصًا جزيئيًا موثوقًا.
- Diagnostic Accuracy: 99.9% sensitivity via ISO‑accredited, CAP‑aligned processing.
- Premium Logistics: Hospital‑grade home collection (8 AM–11 PM) with ISO‑certified cold‑chain transport.
- Clinical Guidance: Post‑test telephonic counselling with a DHA‑licensed genetic counsellor included.
- Insurance & Billing: Direct insurance verification via WhatsApp +971 54 548 8731 — coverage confirmation in under 2 hours.
Compliance: Fully compliant with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 (minor consent protocol), and UAE PDPL data privacy standards. All genetic counselling sessions adhere to DHA & MOHAP regulations.
Test Overview: ITK Gene & Lymphoproliferative Syndrome Type 1
The test sequences the ITK gene using Illumina NGS technology to identify loss‑of‑function mutations that disrupt T‑cell signalling, leading to combined immunodeficiency and Epstein‑Barr virus (EBV)‑driven lymphoproliferation. Results empower hematologists, oncologists, and clinical immunologists to confirm a molecular diagnosis and tailor immune‑modulating therapies.
| Feature | Our NGS ITK Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Gene Coverage | Full coding exons + splice sites (±20 bp) | Selected exons only |
| Analytical Sensitivity | >99.9% (detects SNVs, indels, CNVs) | ~95% (misses deep intronic variants) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Interpretation | ACMG‑guided, multi‑disciplinary review | Basic variant report |
| Genetic Counselling | Pre‑ & post‑test session included | Often not provided |
Physician Insight & Safety Protocol
“As a hematopathologist, I understand the emotional burden that comes with testing for a rare immunodeficiency. While this test offers a powerful molecular window, a negative result does not completely rule out the condition if clinical suspicion remains high. Interpretation must always be integrated with immunological assays, EBV viral load, and family history. My team is committed to walking you through every result with clarity and compassion.”
— Dr. Prabhakar Reddy, DHA License 61713011
⚠ Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Active severe systemic infection or hemodynamic instability that could compromise sample integrity or patient safety during home phlebotomy. Pause testing until clinical stabilisation.
- Exclusion: Known hematocrit <25% (risk of insufficient DNA yield from blood spots) – consider extracted DNA alternative.
- ER Red Flag: If you experience sudden massive lymph node enlargement, difficulty breathing, or high fever after the test (though the draw is minimally invasive), seek emergency care immediately – these symptoms may reflect underlying disease acceleration, not the test.
MEDICATION WARNING: Do not discontinue prescribed immunosuppressants, antivirals, or any other medication without consulting your treating physician. This test does not replace clinical management.
Pre‑Test Requirements & Sample Logistics
A detailed clinical history documenting lymphoproliferative symptoms and a mandatory genetic counselling session are required to construct a pedigree of family members affected by ITK gene mutations. The counselling can be conducted via secure telehealth before sample collection.
Accepted Sample Types: Whole Blood (EDTA), Extracted DNA, or One Drop Blood on FTA Card. Our phlebotomist will select the optimal matrix based on your clinical condition.
Patient FAQ & Clinical Guidance
1. What exactly does the ITK Gene NGS test detect?
Detects ITK gene mutations causing lymphoproliferative syndrome type 1, a primary immunodeficiency predisposing to lymphoma. The assay screens the entire coding region and splice‑site boundaries for single nucleotide variants (SNVs), small insertions/deletions (indels), and copy‑number changes that abolish ITK protein function, thereby confirming the molecular diagnosis of LPFS1.
يكتشف تحليل جين ITK الطفرات المسببة لمتلازمة التكاثر اللمفاوي من النوع الأول، وهو نقص مناعي أولي يؤدي إلى التعرض للأورام اللمفاوية. يفحص الاختبار كامل المنطقة المشفرة وحدود الوصلات لتأكيد التشخيص الجزيئي.
2. How is the sample collected and what should I expect?
A simple blood draw, dried blood spot card, or extracted DNA sample is collected via hospital‑grade home phlebotomy service from 8 AM to 11 PM. Our MOHAP‑licensed phlebotomist arrives with full PPE and ISO‑validated cold‑chain kit; the procedure takes under 5 minutes and requires no fasting, allowing you to continue normal activities immediately afterwards.
يتم جمع العينة عبر سحب دم بسيط أو بقعة دم جافة بواسطة فريق تمريض منزلي مرخص من وزارة الصحة بين 8 صباحًا و11 مساءً. لا يتطلب الإجراء أي تحضير مسبق ويمكنك متابعة أنشطتك الطبيعية بعده.
3. When will I receive my ITK genetic test results?
Results are delivered within 3 to 4 weeks due to comprehensive NGS analysis and clinical interpretation by expert molecular pathologists. This interval includes DNA extraction, library preparation, high‑depth sequencing, bioinformatic alignment to the ITK reference, variant classification per ACMG guidelines, and a multi‑disciplinary case review to ensure the report provides actionable clinical insights.
تصدر النتائج في غضون 3 إلى 4 أسابيع لضمان تحليل شامل وتفسير سريري دقيق من قبل أخصائيي الأمراض الجزيئية. تشمل الفترة استخراج الحمض النووي وإعداد المكتبة والتحليل المعلوماتي والمراجعة السريرية.
For immediate booking or insurance clarification, message +971 54 548 8731 on WhatsApp.
ISO 9001:2015 Certified | Cert INT/EGQ/2509DA/3139 | All tests performed in DHA/MOHAP‑licensed facility (License 9834453).
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians