Test Price
2,800 AEDโ Home Collection Available
IKBKG (NEMO) Gene Sequencing for Primary Immunodeficiency & Atypical Mycobacterial Infection Susceptibility | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity through ISO 9001:2015 accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM โ 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Interpretation by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test uses Next-Generation Sequencing to analyze the entire IKBKG (NEMO) gene for pathogenic variants associated with primary immunodeficiency, ectodermal dysplasia, and susceptibility to atypical mycobacterial infections. It is the definitive genetic diagnostic tool for EDA-ID and related combined immunodeficiencies, delivering results in 3โ4 weeks.
| Feature | Our Test (IKBKG NGS) | Closest Alternative (Targeted PCR) |
|---|---|---|
| Analytical Sensitivity | >99.9% (full gene coverage, CNV detection) | ~85% (only known common mutations) |
| Method | NGS with deletion/duplication analysis | Sanger sequencing of selected exons |
| Turnaround Time | 3โ4 Weeks | 2โ3 Weeks (limited scope) |
| Regulatory Compliance | ISO 9001:2015, DHA/MOHAP, UAE PDPL | Variable |
Physician Insight & Safety Protocols
โAs a Consultant Medical Geneticist, I emphasize that genetic testing for IKBKG is not merely a diagnosis but a roadmap for personalized immuno-management. This comprehensive NGS analysis unveils the underlying immunodeficiency, enabling tailored therapeutic decisions. Every finding must be correlated with the patientโs clinical and immunological profile. We are dedicated to guiding you through this process with compassion and expertise.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication or prophylactic antibiotics without consulting your doctor. Genetic testing may inform long-term management but does not replace acute clinical decisions.
Exclusion Criteria & Emergency Red Flags
- Individuals without clinical indication for IKBKG testing (e.g., asymptomatic adults with no family history).
- Minors unable to provide assent; requires legal guardian consent with genetic counselling documentation as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Patients currently hospitalized for acute life-threatening infection โ test should be deferred until stabilization.
ER Red Flags โ Seek immediate medical attention if:
- High fever, chills, or signs of disseminated mycobacterial infection.
- Severe respiratory distress or altered consciousness.
Patient FAQ & Clinical Guidance
1. What does the IKBKG gene test diagnose?
This NGS test identifies pathogenic variants in the IKBKG (NEMO) gene that cause primary immunodeficiency, anhidrotic ectodermal dysplasia, and severe susceptibility to atypical mycobacterial infections.
2. Who should consider this test?
Patients with recurrent severe mycobacterial infections, ectodermal anomalies, and family history suggesting X-linked recessive immune deficiency are ideal candidates for IKBKG gene sequencing.
3. How is the test performed and what are the requirements?
A simple blood draw, one-drop FTA card, or previously extracted DNA is collected; mandatory pre-genetic counselling ensures pedigree documentation and informed consent.
UAE Regulatory & Data Privacy Adherence
The laboratory operates under DHA Facility License No. 1143. All genetic testing and data processing are conducted in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Results are handled with strict confidentiality and are accessible only to the referring physician.
Clinical & Logistical Metadata
| Test Name | IKBKG (NEMO) Gene Sequencing โ Full NGS Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, FTA Card, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Detection |
| ICD-10-CM Code | D84.8 (Other specified immunodeficiencies), A31.0 (Pulmonary mycobacterial infection) |
| LOINC Code | 92848-8 |
| DHA Facility License & Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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