Test Price
2,800 AED✅ Home Collection Available
HMG20B Gene Dysmorphism Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited Next Generation Sequencing, confirmed with Sanger verification.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance to interpret results in the context of your medical history.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. We verify coverage prior to draw.
This test is performed at our DHA-licensed facility (License No. 1143) in Dubai Healthcare City, adhering to UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The HMG20B Gene Dysmorphism Genetic Test analyzes the entire coding region of the HMG20B gene to detect sequence variants associated with multiple congenital anomaly syndromes, neurodevelopmental disorders, and dysmorphic features. By employing high-depth next-generation sequencing (NovaSeq X Plus) the test delivers a 99.9% diagnostic sensitivity for causative variants linked to pediatric dysmorphology. All pathogenic or likely pathogenic findings are confirmed via Sanger sequencing.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Regional Labs) |
|---|---|---|
| Methodology | NGS with Sanger confirmation, >99.9% analytical sensitivity | NGS only, no orthogonal validation |
| Turnaround Time | 3–4 weeks (expedited options available) | 4–6 weeks |
| Pre-Test Genetic Counseling | Included (pedigree charting, session by certified genetic counselor) | Not routinely provided |
| Regulatory Accreditation | ISO 9001:2015 & DHA Licensed (Facility 1143) | Varies by lab |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I emphasize that a genetic result from HMG20B analysis is a piece of a complex clinical puzzle. Variants of uncertain significance require correlation with detailed dysmorphology examinations and family history before any clinical decisions are made. This test is powerful but must be interpreted by a multidisciplinary team.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
⚠️ Medication & Treatment Advisory
Do not discontinue or modify any prescribed medication or therapy based solely on genetic test results without consulting your treating physician. Clinical correlation is mandatory.
Patient Safety: Exclusion Criteria & Emergency Red Flags
- Exclusion: Not indicated for stable or asymptomatic adults without dysmorphic features or neurodevelopmental delay; family screening only following confirmed pathogenic variant in proband.
- Exclusion: Cannot be performed on clotted or hemolyzed blood samples; use only whole blood in EDTA, extracted DNA, or a validated FTA card.
- ER Red Flags – Seek immediate medical attention if: your child develops new seizures, respiratory distress, cyanosis, or acute neurological deterioration following a known dysmorphic syndrome; test results cannot substitute for emergent clinical evaluation.
Patient FAQ & Clinical Guidance
1. What does a positive HMG20B variant mean for my child’s health and development?
A positive result in the HMG20B gene indicates a likely or definite genetic cause for the observed dysmorphic features and/or neurodevelopmental delay, enabling personalized medical management, early intervention, and accurate recurrence-risk counseling for the family. A pathogenic variant confirms the diagnosis, but variants of uncertain significance require expert reinterpretation over time.
2. Is pre-test genetic counseling required before this test?
Yes, pre-test genetic counseling is a critical step to understand the indications for testing, construct a three-generation pedigree, and ensure informed consent. Our laboratory includes a comprehensive counseling session with a certified genetic counselor as part of the service.
3. How is my DNA sample handled and what privacy protections are in place?
Your DNA sample is processed entirely within our DHA-licensed facility (License 1143) in the UAE and never exported, in strict compliance with Federal Decree-Law No. 45 of 2021 (PDPL) on data privacy. All genomic data is encrypted and stored on secure servers with access limited to certified laboratory personnel and the ordering physician; results are shared only via an encrypted portal or direct physician communication.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with the following UAE legal frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
- ISO 9001:2015 Quality Management System (Certified)
- DHA Facility License No. 1143, Dubai Healthcare City
For genetic testing of minors, legal guardian consent is mandatory. All results are communicated through secure channels respecting patient confidentiality.
Clinical & Logistical Metadata
| Test Name | HMG20B Gene Dysmorphism Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks (expedited options available) |
| Sample Type / Matrix | Peripheral whole blood in EDTA, extracted DNA, or validated FTA card |
| Methodology Used | Next Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 81317-0 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
Home collection available daily from 8 AM to 11 PM. For insurance verification or billing inquiries, contact us via WhatsApp at +971 54 548 8731.
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians