Test Price
2,800 AED✅ Home Collection Available
GFI1 Gene Genetic Test for Nonimmune Chronic Idiopathic Neutropenia of Adults (NI-CINA) in UAE
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity: Guaranteed via ISO 15189 and ISO 9001:2015 accredited NGS laboratory processing at DNA Labs UAE.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection: Paid hospital-grade home collection by DHA-licensed phlebotomists across all UAE emirates, available daily from 8 AM to 11 PM.
- Complimentary Post-Test Genetic Counseling: Telephonic consultation with a DHA-licensed Consultant Medical Genetics for result interpretation and clinical management planning.
- Direct Insurance Billing Verification: Submit via WhatsApp at +971 54 548 8731; all major UAE insurers accepted.
- Price: 2,800 AED inclusive of home collection, laboratory analysis, and post-test counseling.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the entire GFI1 gene to detect pathogenic variants linked to nonimmune chronic idiopathic neutropenia of adults (NI-CINA), a condition causing persistently low neutrophil counts without identifiable immune destruction. Identifying a GFI1 mutation confirms a genetic etiology, enables targeted surveillance, and guides prophylactic therapy to reduce infection risk.
Mandatory Pre-Test Requirement: A genetic counseling session with a licensed genetics professional to document a three-generation pedigree and assess family history of neutropenia must be completed before sample collection.
| Feature | NGS GFI1 Gene Test | Conventional Sanger Sequencing |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity, full gene coverage including intronic regions | ~95% sensitivity, limited to known hotspot exons |
| Method | Next-Generation Sequencing with deep bidirectional coverage | Sanger sequencing of selected exons only |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Sample Requirement | Whole blood or buccal swab, no special transport media required | Whole blood only, higher volume needed |
Physician Insight & Safety Protocols
“A confirmed pathogenic GFI1 variant strongly supports the diagnosis of nonimmune chronic idiopathic neutropenia in adults. However, the genetic result must be interpreted alongside serial absolute neutrophil counts, bone marrow aspirate findings, and the patient's infection history. A negative GFI1 test does not exclude other genetic neutropenias (e.g., ELANE, HAX1, G6PC3), and long-term hematological surveillance remains essential.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
Do not alter or discontinue prescribed medications such as granulocyte colony-stimulating factor (G-CSF) or prophylactic antibiotics without direct consultation with your treating hematologist.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with known autoimmune neutropenia, active chemotherapy, or current acute infection requiring immediate medical intervention.
- Red Flag – Seek Emergency Care: Fever ≥ 38.3°C, severe fatigue, signs of sepsis, or absolute neutrophil count < 0.2 × 10⁹/L.
Patient FAQ & Clinical Guidance
1. What is the GFI1 gene test used for?
This NGS-based test detects genetic variants in the GFI1 gene that cause nonimmune chronic idiopathic neutropenia in adults. The result helps confirm a genetic diagnosis, stratify infection risk, and guide personalized management including G-CSF therapy and infection prophylaxis.
2. How is the sample collected and what is the cost in UAE?
A DHA-licensed phlebotomist collects a whole blood sample at your home across all UAE emirates. The all-inclusive cost is 2,800 AED covering home collection, NGS analysis, and a post-test genetic counseling session.
3. When will I receive my result and how is it interpreted?
Results are delivered within 3 to 4 weeks from sample receipt. A post-test telephonic consultation with our Consultant Medical Genetics is provided to explain the clinical significance of the findings and recommend下一步 management steps.
4. Is pre-test genetic counseling mandatory?
Yes. A genetic counseling session to document a detailed pedigree and assess family history of neutropenia is required before sample collection to ensure informed consent and appropriate test selection.
5. Does insurance cover this test?
DNA Labs UAE has direct billing agreements with all major UAE insurers. Send your insurance details via WhatsApp at +971 54 548 8731 for a pre-authorization verification within 24 hours.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling, storage, and sharing. All genetic data is encrypted and accessible only to the referring physician and the patient. Our laboratory information system complies with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields to ensure secure electronic health records. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 15189 and ISO 9001:2015 accreditation for quality and competence.
Clinical & Logistical Metadata
| Test Name | GFI1 Gene NGS Analysis for Nonimmune Chronic Idiopathic Neutropenia of Adults (NI-CINA) |
| Price (AED) | 2,800 AED (includes home collection, NGS analysis, and post-test genetic counseling) |
| Turnaround Time | 3 to 4 Weeks from sample receipt at laboratory |
| Sample Type / Matrix | Whole blood (EDTA tube) or buccal swab; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – full gene coverage with deep bidirectional reads |
| ICD-10-CM Code | D70.0 |
| LOINC Code | 81305-5 |
| DHA Facility License & Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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