Test Price
2,800 AED✅ Home Collection Available
GDF2 Gene Hereditary Hemorrhagic Telangiectasia Type 5 (HHT5) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين GDF2 للكشف عن توسع الشعيرات النزفي الوراثي من النوع الخامس (HHT5) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- ✓Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed experts.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: اختبار جيني معتمد وفقًا لأعلى معايير الجودة الإماراتية يضمن حساسية تشخيصية بنسبة 99.9%، مع جلسات استشارة وراثية متكاملة لراحة البال.
Test Overview
This next-generation sequencing (NGS) test analyzes the GDF2 gene for pathogenic variants causing Hereditary Hemorrhagic Telangiectasia Type 5 (HHT5), a rare vascular disorder that leads to arteriovenous malformations and telangiectasias. The assay provides definitive molecular diagnosis and enables risk stratification for affected families in the UAE.
| Feature | Our Test (GDF2 NGS) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) | Sanger Sequencing |
| Variant Coverage | Whole gene (coding regions + splice sites) with >99% analytical sensitivity | Targeted exon analysis; may miss deep intronic or copy-number variants |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Options | Whole Blood, Extracted DNA, Dried Blood Spot (FTA Card) | Whole Blood or Extracted DNA |
Physician Insight & Safety Protocol
“As a clinician, I understand that genetic testing can be overwhelming. This test empowers you with critical knowledge, but it must be interpreted alongside your clinical symptoms and family history. Always consult your healthcare provider for a holistic management plan.” — Dr. PRABHAKAR REDDY, DHA License No. 61713011
🛑 Important Medication Warning:
Do not discontinue prescribed medication without consulting your doctor. Genetic results do not replace ongoing clinical care.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not indicated for asymptomatic individuals without a family history of HHT or for recreational genetic exploration without proper counseling.
- Exclusion: Patients with active, uncontrolled epistaxis or gastrointestinal bleeding should be clinically stabilized before blood draw.
- Red Flag: Seek immediate emergency care if you experience sudden severe headache, acute chest pain, massive GI bleeding, or stroke-like symptoms.
Patient FAQ & Clinical Guidance
Q: What is the GDF2 gene and its role in HHT5?
GDF2 gene mutations disrupt BMP9 signaling, leading to HHT5 characterized by arteriovenous malformations and telangiectasias. The GDF2 gene encodes bone morphogenetic protein 9 (BMP9), a crucial growth factor for blood vessel integrity. Pathogenic variants cause type 5 hereditary hemorrhagic telangiectasia, often presenting with recurrent nosebleeds, skin telangiectasias, and internal vascular lesions. Genetic confirmation allows targeted surveillance and family screening.
طفرات جين GDF2 تعطل إشارات BMP9 مؤدية إلى توسع الشعيرات النزفي الوراثي من النوع الخامس (HHT5). ينتج الجين بروتيناً أساسياً للحفاظ على سلامة الأوعية الدموية، وتسبب طفراته تشوهات شريانية وريدية ونزيفاً متكرراً. يساعد الاختبار الجيني في تأكيد التشخيص وتوجيه الفحوصات الدورية للأقارب.
Q: Who should consider this genetic test?
Recurrent nosebleeds and telangiectasias warrant GDF2 genetic testing to confirm HHT5 and guide surveillance. Additionally, individuals with a first-degree relative diagnosed with HHT or a known familial GDF2 mutation are strong candidates. Even if you are asymptomatic, predictive testing can clarify risk and enable early intervention, provided you receive comprehensive pre-test genetic counseling.
نوبات النزيف الأنفي المتكررة وتوسعات الشعيرات الجلدية تستدعي إجراء اختبار جين GDF2. يُوصى بالفحص أيضاً لمن لديهم تاريخ عائلي مؤكد لمرض HHT أو طفرة معروفة في الجين، مع استشارة وراثية مسبقة لتقييم المنافع والمخاطر.
Q: How accurate is the NGS test for HHT5 and what does the result mean?
NGS achieves >99% sensitivity for GDF2, confirming HHT5 diagnosis when symptoms and family history align. A positive result confirms the presence of a disease-causing variant and allows targeted management. A negative result in a symptomatic individual may suggest other HHT genes, requiring extended panels. All results are interpreted by board-certified molecular geneticists and cross-referenced with 2026 ACMG guidelines.
تقنية التسلسل الجيني المتقدم (NGS) تحقق حساسية تزيد عن 99% وتؤكد التشخيص عند توافق الأعراض. النتيجة الإيجابية تؤكد وجود الطفرة وتوجه العلاج، بينما لا تستبعد النتيجة السلبية أسباباً جينية أخرى، ويمكن عندها توسيع التحليل.
Pre‑ Information
- A detailed clinical history and a three‑generation pedigree drawn during a genetic counseling session are required prior to sample collection.
- Sample types accepted: Whole Blood (EDTA), Extracted DNA, or One drop of blood on FTA Card.
- No special preparation; however, inform the phlebotomist if you take anticoagulants.
- Minors must be accompanied by a legal guardian, in compliance with UAE CDS Law 2026 and PDPL.
This service is provided by a DHA-licensed facility (License No. 9834453) under Federal Decree-Law No. 41 of 2024 (Art. 87) and UAE Personal Data Protection Law. Genetic data is encrypted and stored within UAE sovereign cloud infrastructure. ISO 9001:2015 Certified (INT/EGQ/2509DA/3139). All clinical interpretations are reviewed by Dr. PRABHAKAR REDDY (DHA: 61713011).
For insurance direct billing verification, contact WhatsApp +971 54 548 8731.
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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