Test Price
2,800 AED✅ Home Collection Available
FBN1 Gene (Marfan/Lipodystrophy) Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
This genetic test delivers comprehensive analysis of the FBN1 gene using next-generation sequencing (NGS) technology, achieving 99.9% diagnostic sensitivity through ISO 9001:2015 accredited processing at DNA Labs UAE. The service includes temperature-controlled cold-chain home collection, telephonic post-test clinical guidance, and direct billing verification via WhatsApp at +971 54 548 8731.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Supervised by: Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Test Overview & Methodology
The FBN1 Gene Genetic Test screens for pathogenic variants in the FBN1 gene associated with Marfan syndrome and select lipodystrophy phenotypes. This analysis enables precise diagnosis, familial risk assessment, and personalized clinical management under DHA and MOHAP standards. The laboratory employs full gene sequencing of the entire FBN1 coding region plus flanking intronic boundaries, providing comprehensive coverage that surpasses targeted hotspot panels.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Methodology | NGS (Full Gene Sequencing) | Targeted Panel / Single‑Gene Sanger |
| Coverage | Entire FBN1 coding region ± flanking introns | Selected hotspots only |
| Turnaround Time | 3–4 Weeks | 4–8 Weeks (variable) |
| Pre‑Test Counselling | Included (pedigree charting & genetic counseling) | Often not provided |
| ISO Accreditation | ISO 9001:2015 | May lack certification |
| Price (AED) | 2,800 | 2,500 – 4,000 |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA Registration ID: 9294403) — Consultant Medical Genetics: “This molecular test provides critical data for diagnosing Marfan syndrome and related FBN1-associated disorders. However, a negative sequencing result does not entirely exclude the clinical diagnosis when characteristic cardiovascular, skeletal, or ocular features are present. Always integrate genetic findings with echocardiographic aortic measurements, slit-lamp ophthalmologic examination, and metabolic screening. Lifelong multidisciplinary surveillance remains mandatory for confirmed cases.”
Advisory Precautions for Patients
Medication Stability Warning
Patients prescribed beta-blockers, angiotensin receptor blockers, or any cardiovascular therapy must not alter or discontinue their medication without direct physician oversight. Abrupt changes can precipitate aortic dissection or acute cardiac decompensation in individuals with Marfan syndrome.
Exclusion Criteria & Safety Red Flags
- Not suitable for individuals unable to provide informed consent or with contraindications to venipuncture.
- Home collection not performed outside the UAE; international samples must follow MOHAP import regulations.
- Emergency Red Flags: Acute chest or back pain, sudden vision loss, severe headache, or respiratory distress require immediate hospital evaluation – do not wait for test scheduling.
- This test does not replace echocardiographic monitoring; annual aortic root measurement remains mandatory for Marfan patients.
Patient FAQ & Clinical Guidance
1. What is the FBN1 gene test used for?
This genetic test detects pathogenic variants in the FBN1 gene linked to Marfan syndrome and lipodystrophy, guiding precise diagnosis and family screening. It helps differentiate Marfan syndrome from other connective tissue disorders, allowing for early cardiac surveillance and personalized therapy. For individuals with familial partial lipodystrophy phenotypes, a positive result clarifies risk and directs metabolic management.
2. How should I prepare for the blood collection?
No fasting or special preparation is required, but a detailed clinical history and a prior genetic counseling session are mandatory. Our team will schedule a certified phlebotomist to collect a whole blood sample at your home between 8 AM and 11 PM, using a cold-chain compliant kit. Please provide all relevant medical reports and a completed pedigree chart at the time of collection.
3. When will I receive my results and who explains them?
Results are delivered within 3 to 4 weeks and include a telephonic post-test clinical guidance session with a specialist. The report is structured with pathogenicity classification, a detailed interpretation, and recommendations for follow-up care. For minors, results are released strictly to legal guardians in compliance with UAE personal data protection regulations.
UAE Regulatory & Data Privacy Adherence
🇦🇪 Data Protection & Clinical Governance Framework
This laboratory operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient information is securely processed and stored. Clinical testing safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The quality management system is certified under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | FBN1 Gene (Marfan/Lipodystrophy) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) — Full Gene Sequencing |
| ICD-10-CM Code | Q87.4, E88.1 |
| LOINC Code | 21647-4 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians