Test Price
2,800 AEDโ Home Collection Available
FAS Gene Autoimmune Lymphoproliferative Syndrome Type 1A (ALPS) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
๐ฌ Diagnostic Accuracy Guarantee
99.9% diagnostic sensitivity and >99.99% analytical specificity via ISO 9001:2015 certified NGS (Cert: INT/EGQ/2509DA/3139).
๐ฅ Premium Home Collection
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily 8 AM โ 11 PM.
๐ Post-Test Clinical Guidance
Complimentary telephonic interpretation session with a DHA-licensed genetic counsellor.
๐ณ Insurance Support
Direct billing verification via WhatsApp at +971 54 548 8731; most major UAE insurers accepted.
DNA Labs UAE offers a comprehensive NGS-based analysis of the FAS gene to confirm clinical diagnosis of Autoimmune Lymphoproliferative Syndrome Type 1A (ALPS), enabling precise risk stratification and tailored management. Our DHA-licensed facility ensures the highest standards of genomic testing and data privacy.
Test Overview & Methodology
This next-generation sequencing test interrogates the entire coding region of the FAS gene to confirm clinical diagnosis of autoimmune lymphoproliferative syndrome type 1A, enabling precise risk stratification and tailored management.
| Feature | Our Test (NGS Full Gene Sequencing) | Targeted Mutation Panel (Reference Lab) |
|---|---|---|
| Methodology | Next-Generation Sequencing (Illuminaยฎ platform, 100x mean depth) | Sanger sequencing of 3-5 hotspots only |
| Analytical Sensitivity | >99.99% (single nucleotide variants & small indels) | ~85-90% (misses deep intronic/novel variants) |
| Turnaround Time | 3-4 weeks | 2-3 weeks |
| Clinical Utility | Confirms diagnosis, familial cascade testing, lymphoma risk | Preliminary screening only |
Physician Insight & Safety Protocols
"This test must always be interpreted in the context of your complete clinical picture and family history. A negative result does not exclude all immune dysregulation disorders, and a variant of uncertain significance warrants further family studies. Your referring immunologist or rheumatologist will guide you through the post-test implications."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ ๏ธ Medication Safety Advisory
Do not discontinue or modify any prescribed medication without consulting your treating physician.
๐ซ Exclusion Criteria & ER Red Flags
- Exclusion: Asymptomatic minors without parental consent, or individuals who have not undergone pre-test genetic counselling.
- Exclusion: Patients with known bone marrow failure not suspected of ALPS (requires separate workup).
- Red Flag: Sudden massive lymphadenopathy, progressive pancytopenia, or night sweats โ seek emergency haematology evaluation immediately.
- Red Flag: Rapid splenomegaly with unexplained bruising or bleeding may indicate aggressive lymphoma requiring urgent imaging.
Patient FAQ & Clinical Guidance
1. What is the purpose of this genetic test?
This test detects FAS gene mutations linked to autoimmune lymphoproliferative syndrome type 1A, confirming diagnosis and informing treatment. It is intended for individuals with clinical suspicion of ALPS based on lymphoproliferation, autoimmunity, and defective lymphocyte apoptosis.
2. How should I prepare for the test?
Provide a detailed clinical history and attend a pre-test genetic counselling session to map your family pedigree. A standard whole blood sample (2-5 mL in EDTA tube) is required. No fasting is needed.
3. How long will results take and what should I do next?
Results are available in 3-4 weeks. A telephonic counselling session will explain findings and next clinical steps. A variant of uncertain significance (VUS) may require familial segregation analysis.
UAE Regulatory & Data Privacy Adherence
๐ก๏ธ Your Data, Protected by UAE Law
DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is anonymized, encrypted, and stored within secure UAE-based servers. Access is restricted to authorized medical personnel only. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Our DHA-licensed facility (License #1143) ensures that every stage of the testing process, from sample collection to result delivery, meets the highest standards of medical confidentiality and regulatory compliance.
Clinical & Logistical Metadata
| Test Name | FAS Gene Autoimmune Lymphoproliferative Syndrome Type 1A (ALPS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Whole Blood (2-5 mL EDTA), Extracted DNA, or FTA Card Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) โ Illuminaยฎ Platform, Full Gene Coverage |
| ICD-10-CM Code | D89.82 |
| LOINC Code | 94087-9 |
| DHA Facility License & Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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