Test Price
2,800 AED✅ Home Collection Available
FAN1 Gene Interstitial Nephritis Karyomegalic Genetic Test in UAE | 2800 AED | DHA-Regulated Precision Diagnostics
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The FAN1 Gene Interstitial Nephritis Karyomegalic Genetic Test is a comprehensive next-generation sequencing analysis designed to detect pathogenic variants in the FAN1 gene associated with karyomegalic interstitial nephritis (KIN), a rare autosomal recessive tubulointerstitial kidney disease. In the UAE, this test serves as a definitive diagnostic and familial screening tool, empowering nephrologists and geneticists to confirm clinical suspicion, guide targeted management, and provide reproductive risk counseling.
| Feature | Our Test (DHA-Regulated) | Alternative Overseas Lab |
|---|---|---|
| Precision | Full gene sequencing with >99% coverage of coding exons & splice sites | Often limited to hotspot panels, missing rare variants |
| Methodology | NGS (Next-Generation Sequencing) with Sanger confirmation of all clinically significant findings | May not include orthogonal validation, increasing false positives |
| Turnaround Time | 3–4 Weeks (rush option available) | 4–6 Weeks, international shipping delays |
Physician Insight & Safety Protocols
"Genetic test results for FAN1 must be interpreted within the full clinical context — including renal biopsy histology, family pedigree, and biochemical markers. A pathogenic variant confirms the diagnosis of karyomegalic interstitial nephritis, but it does not replace ongoing nephrological monitoring. I strongly recommend that patients continue all prescribed renal protective therapies and attend regular follow-ups. The integration of genomic data with clinical acumen is the cornerstone of precision nephrology in the UAE." – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Guidelines for Specimen Collection
Sample Collection Notes: This test requires a standard venous blood draw (2–5 mL in an EDTA tube) or an extracted DNA sample. No fasting is necessary. Home collection is available daily from 8 AM to 11 PM via VIP Mobile Phlebotomy with temperature-controlled cold-chain logistics for specimen integrity. Please inform the phlebotomist of any active infections or bleeding disorders prior to collection.
Exclusion Criteria & Safety Red Flags
Do Not Proceed If Any of the Following Apply
- Active fever, uncontrolled infection, or acute systemic illness — reschedule collection.
- This test is not indicated for acute kidney injury evaluation; seek emergency care for sudden oliguria, hematuria, or flank pain.
- Pediatric testing requires a valid consent form signed by a legal guardian in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Individuals on chronic immunosuppression should inform the phlebotomist for appropriate safety precautions.
- Emergency Red Flags: Sudden vision changes, severe headache with hypertension, or rapid decline in urine output require immediate emergency medical attention irrespective of genetic test results.
Patient FAQ & Clinical Guidance
1. What is the FAN1 gene and why is this test important?
The FAN1 gene encodes a DNA repair protein; biallelic loss-of-function mutations cause karyomegalic interstitial nephritis, a progressive kidney disease that can lead to end-stage renal failure. Detecting these mutations allows precise diagnosis, informed family screening, and early nephroprotective interventions.
2. How is the sample collected?
A standard venous blood draw (2–5 mL in an EDTA tube) is all that is needed; no fasting is required. Alternatively, we can accept extracted DNA. Home collection is available for your convenience via VIP Mobile Phlebotomy with strict cold-chain transport ensuring specimen integrity.
3. How accurate is this test and can it rule out other renal diseases?
This NGS assay provides 99.9% analytical sensitivity and specificity for the FAN1 gene; however, it targets only KIN-related variants. A negative result does not exclude other genetic or acquired nephropathies, and correlation with renal biopsy and biochemical markers remains essential.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance: This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic information is stored, processed, and transmitted exclusively within DHA-licensed facilities under strict confidentiality protocols. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | FAN1 Gene Interstitial Nephritis Karyomegalic Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | N11.8, Z15.8, N18.9 |
| LOINC Code | 58536-9 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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