Test Price
2,800 AED✅ Home Collection Available
ENAM Gene Amelogenesis Imperfecta Type 1C Genetic Test in UAE | 2800 AED | Precision Genetic Diagnostics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Executive Summary & Core Metrics
Test Price: 2,800 AED
Turnaround Time: 3–4 weeks from sample receipt
Sample Type: Whole blood or Dried Blood Spot (FTA Card)
Methodology: Next-Generation Sequencing (NGS) – Full Gene Analysis
Test Overview & Methodology
The ENAM Gene Amelogenesis Imperfecta Type 1C Genetic Test is a comprehensive next-generation sequencing assay that analyzes the entire ENAM gene for pathogenic variants linked to hypocalcified amelogenesis imperfecta—a hereditary enamel defect leading to soft, friable enamel and early tooth wear. This test delivers a definitive molecular diagnosis, guiding targeted dental management, genetic counseling, and family risk assessment.
Mutations in the ENAM gene cause autosomal dominant or recessive forms of amelogenesis imperfecta, characterized by deficient enamel matrix protein production. NGS technology enables simultaneous detection of point mutations, small insertions/deletions, and copy number variants across all coding exons and flanking intronic regions, providing a complete genetic picture in a single analysis.
| Feature | Our ENAM NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision/Method | Full gene NGS, detecting point mutations, indels, and copy number variants (CNVs) with >99% analytical sensitivity | Targeted Sanger sequencing of coding exons only; may miss deep intronic variants and large deletions |
| Turnaround Time | 3–4 weeks from sample receipt | 4–6 weeks, often longer with batch processing |
| Clinical Utility | Comprehensive, allowing detection of novel and known variants; supports genotype–phenotype correlation and family screening | Limited to known hotspot mutations; may require sequential single-exon tests if negative |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant Medical Geneticist, I recognize the profound impact a molecular diagnosis of amelogenesis imperfecta can have on a patient's oral health trajectory and family planning. Our multidisciplinary team—collaborating with pediatric dentists, prosthodontists, and genetic counselors—interprets every genetic finding within the context of complete clinical history and dental phenotyping. We ensure each patient receives not only a definitive molecular report but a comprehensive care roadmap addressing restorative management, preventive surveillance, and reproductive options, all aligned with international best practices and UAE healthcare standards."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Critical Safety Advisory
⚠️ Do not discontinue any prescribed medication without consulting your treating physician. This test does not replace regular dental or medical follow-up.
All genetic testing requires pre-test counseling to ensure informed consent and understanding of potential implications for family members. If you experience any adverse symptoms following sample collection, seek immediate medical attention.
Test Exclusion Criteria & Emergency Red Flags
- Inability to provide valid informed consent (mandatory genetic counseling session required prior to testing).
- Active, untreated oral infections that may compromise sample integrity or risk contamination.
- Known severe coagulopathy or bleeding disorder if venous blood draw is the sample type; alternative dried blood spot (FTA card) may be used after phlebotomist evaluation.
- Emergency Red Flags: Seek immediate medical attention if you experience excessive bleeding, swelling, or signs of infection at the collection site, or any systemic allergic reaction (rash, difficulty breathing) following sample collection.
Patient FAQ & Clinical Guidance
1. What is the purpose of the ENAM gene test, and how will it help me or my child?
The ENAM gene test identifies pathogenic mutations causing amelogenesis imperfecta type 1C, enabling accurate diagnosis and personalized dental and genetic counseling. Early molecular confirmation allows your dentist to plan protective restorations, anticipate enamel deterioration, and screen at-risk family members, ultimately preserving oral function and aesthetics. A definitive genetic diagnosis also avoids unnecessary investigations and guides appropriate specialist referrals.
2. How is the sample collected, and is it painful?
Sample collection is minimally invasive; a small blood draw or dried blood spot on an FTA card is taken by a certified phlebotomist, with minimal discomfort. For infants or needle-averse individuals, the FTA card requires only a single drop of blood from a finger or heel prick, making the process quick and well-tolerated. Our VIP mobile phlebotomy service brings this collection to your home at your convenience between 8 AM and 11 PM daily.
3. How long does it take to receive results, and how will they be communicated?
Results are available within 3 to 4 weeks from sample receipt, due to the comprehensive NGS analysis and rigorous quality control. A telephonic post-test consultation with our clinical geneticist is scheduled to explain findings, implications, and recommended next steps; a detailed report is also securely delivered via encrypted email or patient portal in compliance with UAE data protection regulations.
4. Will my insurance cover the cost of this genetic test?
Coverage varies by insurance provider and policy. We offer direct billing verification through our WhatsApp service at +971 54 548 8731. Our team can check your eligibility and provide an estimate of any out-of-pocket costs before testing begins. Many UAE insurance plans provide partial or full coverage for genetic testing when deemed medically necessary by a referring physician.
UAE Regulatory & Data Privacy Adherence
Your data privacy and clinical safety are protected under UAE law:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Governs the collection, processing, and storage of your personal and genetic data, ensuring lawful handling and your right to access, rectify, or erase your information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Regulates electronic health data exchange, mandating encryption, access controls, and audit trails for all digital health records and test results.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Establishes the legal framework for clinical safety, patient consent, and professional accountability across all diagnostic procedures.
All genetic data is processed in ISO-accredited laboratories with strict confidentiality protocols. Results are shared only with the patient and their designated healthcare providers unless explicit written consent is provided for additional disclosures.
Clinical & Logistical Metadata
| Test Name | ENAM Gene Amelogenesis Imperfecta Type 1C Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole Blood (EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coding regions and flanking intronic sequences |
| ICD-10-CM Code | K00.4 (Amelogenesis imperfecta) |
| LOINC Code | 81261-8 (ENAM gene mutations detected in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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