Test Price
2,800 AEDโ Home Collection Available
ENAM Gene Amelogenesis Imperfecta Type 1B Genetic Test
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Corporate Lab: DNA Labs UAE โ DHA Facility License No. 1143.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test detects pathogenic variants in the ENAM gene to confirm Amelogenesis Imperfecta Type 1B, a hereditary enamel defect. The test provides molecular confirmation of the clinical diagnosis, enabling personalized dental restorative treatment, orthodontic planning, and genetic counseling for family members. It is particularly indicated when there is a family history of enamel defects or syndromic features involving skin and teeth.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Massively Parallel Sequencing | Single Gene Sanger |
| Coverage | Full coding region + splice sites | Limited to known hotspots |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Diagnostic Yield | >99% for SNVs & small indels | ~95% |
Physician Insight & Safety Protocols
โDental enamel defects can significantly impact a patientโs quality of life and self-esteem. This NGS-based genetic test provides a definitive molecular diagnosis for Amelogenesis Imperfecta Type 1B, guiding tailored restorative and orthodontic interventions. I always recommend combining genetic results with a thorough clinical and radiographic evaluation by a multidisciplinary team including a dentist and a clinical geneticist.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
โ ๏ธ Do not discontinue any prescribed medication without consulting your treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Known severe bleeding disorder (e.g., hemophilia), acute systemic infection, or inability to provide informed consent. An alternative non-invasive sample (buccal swab) may be discussed.
- ER Red Flags: If you experience excessive bleeding, fainting, chest pain, or signs of infection (redness, pus) at the collection site after sample provision, seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What does the ENAM gene test diagnose?
The ENAM genetic test diagnoses Amelogenesis Imperfecta Type 1B by identifying mutations in the enamelin gene that cause thin, pitted, or discolored teeth. The test provides molecular confirmation of the clinical diagnosis, enabling personalized dental restorative treatment, orthodontic planning, and genetic counseling for family members.
2. How is the test performed and is it safe?
A simple blood draw or buccal swab is collected by a certified phlebotomist. Risks are minimal, with mild bruising possible at the venipuncture site. Samples are transported in ISO-certified cold-chain conditions adhering to DHA infection control standards. Most individuals resume daily activities immediately after collection.
3. When will I receive my results and what do they include?
Results are delivered within 3โ4 weeks in a secure digital report with clinical interpretation, variant classification per ACMG guidelines, and genetic counseling guidance. A post-test tele-consultation with a genetic counselor is available to explain findings and discuss next steps.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance: All genetic data is stored and processed exclusively within UAE sovereign cloud infrastructure in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certificate: INT/EGQ/2509DA/3139.
Clinical & Logistical Metadata
| Test Name | ENAM Gene Amelogenesis Imperfecta Type 1B Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21โ28 Days (3โ4 Weeks) |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) โ Massively Parallel Sequencing |
| ICD-10-CM Code | K00.5, K00.4 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians