Test Price
2,800 AED✅ Home Collection Available
CYP11B2 Genetic Test for Congenital Hypoaldosteronism (CMO I Deficiency) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين CYP11B2 لنقص الألدوستيرون الخلقي (عوز CMO I) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary (ملخص تنفيذي)
This definitive Next‑Generation Sequencing (NGS) test analyses the entire CYP11B2 gene to confirm Congenital Hypoaldosteronism due to Corticosterone Methyl Oxidase I (CMO I) deficiency, a rare but treatable salt‑wasting disorder. Delivered under ISO 9001:2015 accredited protocols, the test achieves 99.9% diagnostic sensitivity and provides a clinical report within 3–4 weeks, supporting precise treatment and family planning.
يقدم هذا التحليل الجيني تشخيصاً دقيقاً لنقص الألدوستيرون الخلقي الناتج عن عوز إنزيم CMO I، بالاعتماد على تقنية التسلسل الجيني من الجيل التالي (NGS) وفق أعلى معايير هيئة الصحة بدبي لعام 2026.
Test Overview
The CYP11B2 Genetic Test screens for pathogenic variants causing congenital hypoaldosteronism type I (CMO I deficiency), an autosomal recessive disorder that leads to life‑threatening salt wasting in infants. Unlike targeted panels, our full‑gene sequencing identifies both known and novel mutations, delivering the most comprehensive molecular diagnosis available in the UAE.
| Feature | Our NGS Test | Conventional Sanger Sequencing |
|---|---|---|
| Precision | 99.9% sensitivity, full gene coverage | ~97% sensitivity, selected exons only |
| Methodology | Illumina® Next‑Generation Sequencing (NGS) | Sanger capillary electrophoresis |
| Turnaround Time | 3–4 weeks | 6–8 weeks (often outsourced) |
| Clinical Utility | Identifies novel variants, guides precise therapy | Limited to common mutations |
Physician Insight & Safety Protocol
"As a clinician, I emphasize that a CYP11B2 mutation can silently manifest with severe dehydration, vomiting, and shock in the neonatal period. This test should be interpreted alongside plasma renin, aldosterone, and electrolyte panels – a negative result does not exclude the diagnosis if clinical suspicion is high. The peace of mind that comes from a definitive molecular diagnosis is invaluable for families and physicians alike."
— Dr. PRABHAKAR REDDY, DHA License No. 61713011
⚠ Medication Warning: Do not discontinue prescribed mineralocorticoid or sodium supplementation without consulting your doctor. This test provides genetic confirmation; treatment adjustments must be made under specialist supervision.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients unable to provide informed consent (or guardian consent for minors) without prior genetic counselling.
- Exclusion: Sample collection must be performed by a certified phlebotomist; self‑collection of blood is not accepted.
- ER Red Flag: Infants with poor feeding, lethargy, marked hyponatremia, hyperkalemia, or shock – seek emergency care immediately.
- ER Red Flag: Sudden onset of severe dehydration or arrhythmias in a child with suspected CMO I deficiency.
Patient FAQ & Clinical Guidance
What are the symptoms and genetic basis of CMO I deficiency, and how does this test help?
CMO I deficiency is a rare autosomal recessive disorder caused by mutations in the CYP11B2 gene, leading to life‑threatening salt‑wasting crises in neonates. يحدث عوز CMO I بسبب طفرات في جين CYP11B2 وينتج عنه هدر ملحي خطير عند الرضع. Our NGS test identifies both known and novel variants, enabling definitive diagnosis, carrier testing, and informed prenatal counselling.
How is the CYP11B2 genetic test performed and what does a positive result mean?
A simple blood draw (2‑3 mL EDTA whole blood) or a single drop on an FTA card is all that is required; DNA is extracted and analysed by Illumina NGS, ensuring 99.9% base‑calling accuracy. يتم سحب عينة دم بسيطة واستخراج الحمض النووي وتحليلها بتقنية التسلسل من الجيل التالي. A positive result confirms the molecular diagnosis, guides mineralocorticoid therapy, and flags family members for cascade screening.
What is the cost, turnaround time, and insurance coverage for this in UAE?
The complete NGS analysis is priced at 2800 AED, with a report delivered in 3–4 weeks after sample reception. تبلغ تكلفة التحليل 2800 درهم إماراتي مع إصدار التقرير خلال 3 إلى 4 أسابيع. We offer direct insurance billing through major UAE networks; WhatsApp us at +971 54 548 8731 with your insurance card to verify eligibility immediately.
UAE Regulatory & Accreditation Compliance
✅ Facility License No. 9834453 · ✅ ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
⚕️ Conducted in full accordance with Federal Decree‑Law No. 41 of 2024 (Art. 87), the CDS Law 2026 (Minors Protection), and the UAE Personal Data Protection Law (PDPL). Your genetic data is stored securely and never shared without explicit consent.
📞 Support & Home Collection: +971 54 548 8731 (24/7 WhatsApp)
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians