Test Price
2,800 AEDโ Home Collection Available
CR2 Gene Common Variable Immunodeficiency Type 7 (CVID7) Genetic Test in Dubai, UAE
Executive Summary & Core Metrics
Executive Summary: The CR2 Gene Common Variable Immunodeficiency Type 7 (CVID7) NGS Test provides precise detection of pathogenic variants in the CR2 gene using Next-Generation Sequencing, achieving >99% diagnostic sensitivity. This test is essential for confirming CVID7, guiding immunoglobulin replacement therapy, and reducing infection risks. Our ISO-accredited laboratory in Dubai Healthcare City offers secure specimen collection and post-test genetic counselling.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM โ 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS assay sequences the full coding region and exon-intron boundaries of the CR2 gene, with concurrent copy number variation analysis. It detects single nucleotide variants, insertions, deletions, and large rearrangements responsible for CVID7. The test is indicated for individuals with recurrent sinopulmonary infections, low immunoglobulins, poor antibody responses, or a family history of primary immunodeficiency.
| Feature | Our Test (CR2 NGS) | Alternative (Single-Gene Sanger) |
|---|---|---|
| Methodology | NGS with full gene coverage & copy number analysis | Limited to known hotspots |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Diagnostic Yield | >95% detection of pathogenic variants | ~70% |
Physician Insight & Safety Protocols
โA pathogenic CR2 variant confirms CVID7, but clinical correlation with immunoglobulin levels, vaccine responses, and infection history is mandatory. A negative result does not exclude other primary immunodeficiencies; always interpret within a comprehensive immunological workup.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Medication Advisory
Do not alter or discontinue prescribed immunoglobulin therapy or immunosuppressants without consulting your treating physician. Abrupt cessation can precipitate severe infections or autoimmune flares. This test is for diagnostic purposes only; treatment decisions must be made by a qualified specialist.
Exclusion Criteria & Red Flags
Patient Safety: Exclusion Criteria & Red Flags
- Exclusion: Patients with active chemotherapy-induced neutropenia (<100 cells/ยตL absolute neutrophil count) may yield insufficient DNA quality.
- Exclusion: Recent blood transfusion (<2 weeks) can introduce donor DNA, obscuring germline variants.
- Red Flag: If the patient presents with acute severe infection, defer elective genetic testing until clinically stable.
- Red Flag: Incidental findings unrelated to immunodeficiency must be reported to the ordering physician immediately for further evaluation.
Patient FAQ & Clinical Guidance
1. What does the CR2 Gene CVID7 NGS test detect and who should consider it?
This test identifies disease-causing DNA sequence changes in the CR2 gene that lead to Common Variable Immunodeficiency Type 7, a condition characterised by low antibody levels and frequent infections. It is recommended for individuals with recurrent respiratory or gastrointestinal infections, poor vaccine responses, unexplained low immunoglobulins, or a family history of primary immunodeficiency.
2. How is the test performed and is home sample collection available in the UAE?
A certified phlebotomist collects a peripheral blood sample (or buccal swab, if preferred) at your home, office, or our collection centre. The specimen is transported under temperature-controlled cold chain to our ISO-accredited laboratory. Home collection is available daily from 8:00 AM to 11:00 PM across the UAE. Turnaround time is 3โ4 weeks, and a post-test teleconsultation with a genetic counsellor is included.
3. Are the results confidential and protected under UAE health data laws?
Yes, all genetic data is stored and processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your information is encrypted, access-restricted, and never shared without your explicit consent.
UAE Regulatory & Data Privacy Adherence
Data Protection & Regulatory Compliance: This service operates in full alignment with Federal Decree-Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019 on Use of ICT in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility is licensed by the Dubai Health Authority (DHA License No. 1143) and located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | CR2 Gene Common Variable Immunodeficiency Type 7 (CVID7) NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) โ full gene coverage with CNV analysis |
| ICD-10-CM Code | D80.1 |
| LOINC Code | 94288-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians