Test Price
2,800 AED✅ Home Collection Available
COL4A3 Gene Alport Syndrome (Autosomal Recessive) – Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين COL4A3 لمتلازمة ألبورت الصبغية الجسدية المتنحية في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي: يقدم هذا الفحص الجيني المتقدم باستخدام تقنية التسلسل الجيني من الجيل التالي (NGS) تحليلاً شاملاً لجين COL4A3 للكشف عن الطفرات المسببة لمتلازمة ألبورت الصبغية الجسدية المتنحية. تبلغ الحساسية التشخيصية للفحص 99.9% عبر معالجتنا المعتمدة بموجب شهادة الأيزو 9001:2015. نلتزم التزاماً كاملاً بالمرسوم الاتحادي بقانون رقم 41 لسنة 2024 (المادة 87) وقانون CDS 2026 الخاص بالقُصَّر وقانون حماية البيانات الشخصية في الإمارات العربية المتحدة. تشمل الخدمة جلسة استشارة وراثية إلزامية قبل الفحص، وسحب عينات منزلية على درجة المستشفى عبر خدمة النقل المبردة المعتمدة، وإرشاد سريري هاتفي بعد ظهور النتائج. للتحقق من التغطية التأمينية المباشرة، يُرجى التواصل عبر تطبيق واتساب على الرقم 545488731 971+.
ISO-Accredited Processing
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Result Interpretation
WhatsApp: +971 54 548 8731
Overview
The COL4A3 Gene Alport Syndrome (Autosomal Recessive) Genetic Test is a definitive molecular diagnostic assay that screens the entire coding region of the COL4A3 gene on chromosome 2q36.3 using Next-Generation Sequencing. This test identifies pathogenic single-nucleotide variants, small insertions/deletions, and copy-number alterations responsible for autosomal recessive Alport syndrome — a progressive disorder characterized by hematuria, sensorineural hearing loss, and ocular abnormalities. يكتشف هذا الفحص الطفرات المسببة لمتلازمة ألبورت المتنحية بدقة فائقة.
| Feature | Our COL4A3 NGS Test | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Precision | Full gene coverage including deep intronic splice regions via NGS | Limited to selected exons only; misses deep intronic variants |
| Methodology | Next-Generation Sequencing (Illumina Platform) with 150× mean read depth | Sanger Sequencing; lower throughput and resolution |
| Turnaround Time | 3 to 4 Weeks with comprehensive clinical interpretation report | 6 to 8 Weeks for equivalent coverage |
| Variant Classification | ACMG/AMP 2026 guidelines with ClinVar cross-referencing | May lack updated classification frameworks |
| Pre-Test Genetic Counselling | Mandatory pedigree-charting session included | Often not included |
Physician Insight & Safety Protocol
"As a clinician, I emphasize that the COL4A3 NGS result is a powerful piece of the diagnostic puzzle — it must always be correlated with renal function tests, audiometry, and ophthalmological findings before reaching a definitive clinical conclusion. I urge every patient to view this genetic report not as an isolated verdict but as a roadmap that, when interpreted alongside your full clinical picture, enables the most precise and personalized management strategy. Your referring physician and our genetic counsellor are your essential partners in navigating any result with clarity and confidence."
— Dr. Prabhakar Reddy, DHA License: 61713011
⚠ Critical Safety Advisory
Do not discontinue or modify any prescribed medication, including ACE inhibitors, angiotensin receptor blockers, or any nephroprotective therapy, without explicit consultation with your treating nephrologist. Genetic test results provide diagnostic clarity but do not replace ongoing clinical management decisions.
Exclusion Criteria & Emergency Red Flags
- Patients currently undergoing active chemotherapy or radiotherapy must defer sample collection until completion of treatment cycle.
- Recipients of allogeneic bone marrow transplantation within the preceding 90 days are excluded due to donor DNA interference.
- Emergency Red Flag: If you experience sudden-onset gross hematuria with flank pain, acute hearing loss, or visual disturbances, seek immediate emergency medical attention — do not wait for genetic test results.
- This test is validated for blood, extracted DNA, or one-drop blood on FTA Card specimens only; buccal swabs are not accepted for this protocol.
- Minors (<18 years) require documented parental or legal guardian consent in strict compliance with UAE CDS Law 2026.
Patient FAQ & Clinical Guidance
Q1: What does a positive COL4A3 genetic test result mean for me and my family?
A positive COL4A3 result confirms the presence of a pathogenic variant causative of autosomal recessive Alport syndrome, requiring both gene copies to be affected for classic disease manifestation, while carriers with only one altered copy may exhibit thin basement membrane nephropathy or remain asymptomatic. This result necessitates cascade screening of first-degree relatives, particularly siblings who have a 25% risk of being affected if both parents are carriers, and should prompt coordinated evaluation by a nephrologist, audiologist, and ophthalmologist to establish baseline organ function and guide long-term surveillance.
Q2: كم تستغرق نتيجة فحص جين COL4A3 وما مدى دقتها؟
يستغرق ظهور نتيجة فحص جين COL4A3 ما بين ثلاثة إلى أربعة أسابيع، وتبلغ الحساسية التشخيصية للفحص 99.9% عند إجرائه وفق معايير المختبر المعتمد بشهادة الأيزو. Our ISO 9001:2015 certified laboratory processes every sample with an average read depth exceeding 150× coverage across all COL4A3 exons, and every pathogenic variant call is independently verified through orthogonal confirmation before the final clinical report is issued and reviewed by our molecular geneticist.
Q3: Is pre-test genetic counselling mandatory before taking this DNA test in the UAE?
Yes, pre-test genetic counselling with a qualified clinical geneticist is mandatory under UAE Federal Decree-Law No. 41 of 2024 and is integrated into our service to draw a comprehensive pedigree chart documenting all family members affected by COL4A3-related conditions. This session ensures you fully understand autosomal recessive inheritance patterns, the implications of identifying carrier status versus affected status, potential psychosocial impacts, and the data privacy protections guaranteed under the UAE Personal Data Protection Law — all before any blood sample is collected at your home or clinic appointment.
Specimen Collection & Logistics
- Accepted Sample Types: Whole Blood (EDTA tube), Extracted DNA, or One Drop Blood on FTA Card
- Home Collection: Available daily 8:00 AM – 11:00 PM via ISO-Certified Cold-Chain Home Phlebotomy
- Turnaround Time: 3 to 4 Weeks from sample accession
- Price: 2,800 AED (includes pre-test genetic counselling session)
- Facility License: DHA 9834453 | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
- Support: WhatsApp +971 54 548 8731 for appointments, insurance verification, and post- guidance
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