Test Price
2,800 AEDโ Home Collection Available
CFI Gene Hemolytic Uremic Syndrome (HUS) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
The CFI Gene HUS NGS Test delivers 99.9% diagnostic sensitivity through ISO-certified processing. We provide premium hospital-grade home collection with cold-chain logistics (8 AMโ11 PM), post-test telephonic clinical guidance for result interpretation, and direct insurance billing verification via WhatsApp at +971 54 548 8731. Turnaround time is 3โ4 weeks.
Test Overview & Methodology
This next-generation sequencing (NGS) test examines the entire coding region of the CFI gene to detect pathogenic variants responsible for complement-mediated atypical hemolytic uremic syndrome (aHUS). It aids nephrologists, clinical geneticists, and general physicians in confirming a genetic predisposition and guiding lifelong management.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Full gene coverage, detects all variant types (SNVs, indels) | Limited to single exon/amplicon; may miss deep intronic mutations |
| Method | Next-Generation Sequencing (NGS) | Sanger sequencing (single-gene, targeted) |
| Turnaround | 3โ4 weeks | 4โ6 weeks |
Physician Insight & Safety Protocols
โThe CFI gene analysis provides a definitive genetic diagnosis for complement-mediated aHUS. I emphasize the importance of correlating these results with complement activity assays for a comprehensive clinical picture. A negative NGS result does not exclude the possibility of a missed variant, and positive findings require careful genetic counselling of the patient and family.โ โ Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ Medication Advisory
Do not discontinue prescribed medication or adjust immunosuppressive therapy without consulting your doctor. Any changes require direct coordination with your treating nephrologist.
Exclusion Criteria & Emergency Red Flags
- Individuals unable to provide a peripheral blood sample due to severe anemia or vascular access issues (consult our phlebotomy team).
- Current acute, severe hemolysis requiring urgent plasmapheresis โ testing should be postponed until clinically stable.
- If you experience sudden confusion, decreased urine output, easy bruising, or chest pain, seek emergency medical care immediately; these may indicate active HUS.
Patient FAQ & Clinical Guidance
1. What is the purpose of the CFI gene test for HUS?
Our NGS test detects CFI gene mutations causing atypical hemolytic uremic syndrome, enabling accurate diagnosis. The test screens the entire CFI gene, identifying even rare mutations that impair complement regulation and lead to kidney microangiopathy.
2. How is the test performed and what sample is required?
A simple blood draw, extracted DNA, or a single blood drop on an FTA card is collected. Pre-genetic counselling is mandatory to document a three-generation pedigree and ensure informed decision-making.
3. What do my results mean and what is the follow-up?
Results detect pathogenic, likely pathogenic, or variants of uncertain significance in CFI. A positive finding confirms genetic complement I deficiency, prompting lifelong nephrology surveillance and potential eculizumab therapy.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our laboratory operates under DHA Facility License No. 1143 and adheres to strict data security and confidentiality protocols.
Clinical & Logistical Metadata
| Test Name | CFI Gene Hemolytic Uremic Syndrome (HUS) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral whole blood |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | D59.32 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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