Test Price
2,800 AED✅ Home Collection Available
CDAN1 Gene Sequencing for Congenital Dyserythropoietic Anemia Type 1A – Genetic Test in Dubai, UAE
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% sensitivity via Next-Generation Sequencing with full CDAN1 gene coverage and AI-assisted variant interpretation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across Dubai and major UAE cities.
- Post-Test Guidance: Telephonic result interpretation and genetic counselling by Consultant Medical Genetics specialists.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731 – pre-approval handling included.
Turnaround Time: 3–4 Weeks | Price: 2,800 AED – DHA Licensed Facility No. 1143
Test Overview & Methodology
This diagnostic assay employs Next-Generation Sequencing (NGS) on the Illumina NovaSeq X Plus platform to perform complete coding region and splice-site analysis of the CDAN1 gene. The test identifies single nucleotide variants (SNVs), small insertions and deletions (indels), and copy number variations associated with congenital dyserythropoietic anemia type 1A (CDA I). Results are interpreted using ACMG-AMP guidelines by board-certified molecular geneticists, providing definitive molecular diagnosis and enabling carrier risk stratification for family planning.
| Feature | DNA Labs UAE – NGS Test | Alternative – Sanger Sequencing |
|---|---|---|
| Diagnostic Sensitivity | 99.9% – full gene coverage including intronic regions | ~95% – limited to known hotspot exons |
| Instrument & Workflow | Illumina NovaSeq X Plus with AI-assisted bioinformatics pipeline | Capillary electrophoresis – manual interpretation |
| Turnaround Time | 3–4 Weeks – comprehensive clinical report | 4–6 Weeks – limited variant scope |
| Variant Detection Spectrum | SNVs, indels, copy number variants, splice-site alterations | SNVs only – no CNV or deep intronic detection |
| Sample Acceptance | Whole Blood, Extracted DNA, FTA Card | Whole Blood only |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I recognise the depth of uncertainty that accompanies suspected inherited anaemia. This NGS-based CDAN1 assay delivers definitive molecular evidence for CDA type I with sensitivity exceeding 99.9%, yet I emphasise that results must always be interpreted alongside full haematological indices, peripheral smear morphology, and a three-generation pedigree. Our multidisciplinary team at DNA Labs UAE ensures each finding is contextualised within the patient's complete clinical narrative."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Pre-Test Advisory
Medication Continuation Notice
Do not discontinue any prescribed medication, including iron chelation therapy or transfusional support, without direct consultation with your haematologist. Genetic test results are one component of a comprehensive diagnostic work-up and should never be used as a sole basis for treatment changes.
Exclusion Criteria & Emergency Red Flags
- Informed Consent: Testing is deferred if the patient or legal guardian cannot provide written informed consent as required under Federal Decree-Law No. 4 of 2016 on Medical Liability. Guardian consent is mandatory for minors.
- Acute Clinical Instability: Samples must not be collected during an acute haemolytic crisis or active systemic infection. Clinical stabilisation is required prior to phlebotomy.
- Sample Adequacy: Insufficient blood volume, haemolysed specimens, or compromised FTA card quality necessitate recollection. Minimum volume: 2 mL whole blood in EDTA.
- 🚨 Emergency Red Flags: Sudden severe pallor, rapid-onset jaundice, chest pain, dyspnoea, or syncope – cease home collection and direct the patient to the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the CDAN1 genetic test and why is it performed?
This NGS-based test sequences the entire CDAN1 gene to detect pathogenic variants responsible for congenital dyserythropoietic anemia type 1A (CDA I). It is indicated for patients with unexplained chronic anaemia, jaundice, hepatosplenomegaly, or a family history suggestive of CDA. The test provides a definitive molecular diagnosis with 99.9% sensitivity and enables carrier screening for at-risk relatives.
2. How is the sample collected and what type is required?
The test accepts whole blood (EDTA tube, 2–4 mL), extracted genomic DNA (1 µg minimum), or a dried blood spot on an FTA card. Our VIP Mobile Phlebotomy service dispatches a certified nurse to your home between 8 AM and 11 PM daily. The sample is transported under temperature-controlled cold-chain to our ISO 9001:2015 certified laboratory in Dubai Healthcare City.
3. Who should consider the CDAN1 NGS test?
Individuals with refractory anaemia of unknown origin, unexplained persistent jaundice, or a confirmed or suspected family history of CDA type I are appropriate candidates. Additionally, couples planning a pregnancy with one partner known to carry a CDAN1 variant, and first-degree relatives of a confirmed case, may benefit from predictive testing and genetic counselling.
4. What is the turnaround time and how will I receive results?
The standard turnaround time is 3 to 4 weeks from sample receipt at our laboratory. Results are delivered via a secure digital portal and include a comprehensive clinical report with variant classification, zygosity, and inheritance-based interpretation. A telephonic consultation with a Consultant Medical Genetics is scheduled to discuss findings and next steps.
5. Is the test covered by insurance in the UAE?
DNA Labs UAE offers direct billing verification for most major UAE health insurance plans. Submit your policy details via WhatsApp +971 54 548 8731 prior to testing, and our billing team will confirm coverage and obtain pre-approval where required. Out-of-pocket price is 2,800 AED inclusive of collection, analysis, and genetic counselling.
UAE Regulatory & Data Privacy Adherence
Legal & Compliance Framework
DNA Labs UAE operates under DHA Facility License No. 1143 and adheres strictly to the following UAE federal statutes:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – All genetic data is classified as sensitive personal data; explicit consent, purpose limitation, and data minimisation are enforced. Data is encrypted at rest and in transit with role-based access controls.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – Electronic health records and telemedicine components of our service comply fully with DHA standards for health information exchange and digital reporting.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – All clinical genetic testing, consent processes, and result interpretation are governed by the provisions of medical liability law, ensuring patient safety and practitioner accountability.
All genetic reports are issued with a unique DHA-compliant identifier and are accessible only to the ordering physician and the patient via secure authenticated channels.
Clinical & Logistical Metadata
| Test Name | CDAN1 Gene Sequencing – Congenital Dyserythropoietic Anemia Type 1A |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted Genomic DNA, FTA Card Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina NovaSeq X Plus, paired-end 150 bp, mean depth >100×, ACMG-AMP variant classification |
| ICD-10-CM Code | D64.0 (Congenital dyserythropoietic anemia) |
| LOINC Code | 81303-1 (CDAN1 gene full sequencing) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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