Test Price
2,800 AED✅ Home Collection Available
CASR Gene (Hypocalciuric Hypercalcemia Type 1) Genetic Test in Dubai | 2,800 AED
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity for pathogenic CASR variants via ISO 15189 accredited next-generation sequencing (NGS) workflow.
- Specimen Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – available daily from 8 AM to 11 PM across all UAE emirates.
- Post-Test Guidance: Telephonic result interpretation and clinical counselling provided by a DHA-licensed Consultant Medical Geneticist.
- Insurance & Billing: Direct billing verification with over 40 UAE insurers via WhatsApp +971 54 548 8731.
- Prerequisite: A detailed clinical history and mandatory pre-test genetic counselling session to construct a family pedigree are required before sample collection. Call +971 54 548 8731 to schedule.
Test Overview & Methodology
This next-generation sequencing assay analyses the entire coding region and flanking intronic boundaries of the CASR gene to detect pathogenic and likely pathogenic variants responsible for familial hypocalciuric hypercalcemia type 1 (FHH1). FHH1 is a benign but clinically important disorder of calcium metabolism that must be differentiated from primary hyperparathyroidism to avoid unnecessary parathyroid surgery. The test provides definitive molecular diagnosis, enables cascade screening for at‑risk family members, and supports lifelong metabolic monitoring under endocrinological supervision.
| Parameter | NGS-Based CASR Gene Test | Conventional Sanger Sequencing |
|---|---|---|
| Genomic Coverage | Full coding region, splice sites, and selected deep intronic regions; variant detection down to 5% allele frequency | Limited to targeted exons; may miss mosaic, deep intronic, or regulatory variants |
| Methodology | Next‑Generation Sequencing (NGS) with bioinformatic annotation and ACMG/AMP variant classification | Capillary electrophoresis Sanger sequencing of individually amplified exons |
| Turnaround Time | 3–4 weeks with expedited clinical reporting | 6–8 weeks for full gene analysis |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Geneticist, I stress that a CASR gene test result must always be interpreted alongside serum calcium, parathyroid hormone, and 24‑hour urinary calcium excretion. This molecular assay is an adjunct to—not a replacement for—comprehensive endocrinological evaluation. Patients should discuss all findings with their referring physician before making any therapeutic changes.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication and Supplement Stability
Do not discontinue any prescribed calcium-regulating medications, vitamin D supplements, or bisphosphonates without explicit instruction from your treating physician. Abrupt withdrawal can precipitate severe hypocalcaemia, tetany, or rebound hypercalcaemia. Always maintain current therapy until a joint clinical decision is made with your healthcare team.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active systemic infection that delays safe blood collection; haemoglobin below 7 g/dL (risk of iatrogenic anaemia).
- Exclusion: Individuals under 18 years of age without a legal guardian present, as mandated by UAE Federal Law.
- Emergency Red Flag: Signs of severe hypercalcaemic crisis—confusion, obtundation, cardiac arrhythmia, or acute renal impairment—require immediate hospital admission and are not suitable for elective outpatient genetic testing.
Patient FAQ & Clinical Guidance
1. How does the NGS CASR gene test differentiate FHH1 from primary hyperparathyroidism?
Our NGS-based CASR gene test detects familial hypocalciuric hypercalcemia type 1 mutations with 99.9% diagnostic sensitivity, enabling a clear molecular distinction from primary hyperparathyroidism without the need for invasive venous sampling or parathyroid imaging. The result directly guides clinical management and prevents unnecessary parathyroidectomy.
2. What sample types are accepted and how is home collection arranged?
We accept whole blood in EDTA tubes, extracted high-quality DNA, or a single blood spot on an FTA card. Our DHA-licensed phlebotomists provide VIP Mobile Phlebotomy with temperature-controlled cold-chain transport from 8 AM to 11 PM daily across all seven UAE emirates. The courier collects and delivers the specimen directly to our ISO 15189 accredited laboratory in Dubai Healthcare City.
3. Is genetic counselling included and does insurance cover the cost?
Yes, a mandatory pre-test genetic counselling session is conducted to draw a three-generation pedigree and obtain informed consent. Post-test, a telephonic consultation with the geneticist explains the result and its implications. We verify direct billing eligibility with over 40 UAE health insurers; send your policy details via WhatsApp to +971 54 548 8731 for an immediate coverage check.
UAE Regulatory & Data Privacy Adherence
All genetic data generated by DNA Labs UAE is handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, stored in UAE‑based servers, and never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | CASR Gene (Hypocalciuric Hypercalcemia Type 1) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (expedited clinical reporting available) |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card blood spot – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region and splice site analysis with ACMG/AMP variant classification |
| ICD-10-CM Code | E83.52 |
| LOINC Code | 74823-8 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians